13 results match your criteria: "University of Estadual Paulista - UNESP[Affiliation]"

Chitosan-Calcium-Simvastatin Scaffold as an Inductive Cell-Free Platform.

J Dent Res

September 2021

Department of Physiology and Pathology, University of Estadual Paulista-UNESP, Araraquara School of Dentistry, Araraquara, SP, Brazil.

The development of biomaterials based on the combination of biopolymers with bioactive compounds to develop delivery systems capable of modulating dentin regeneration mediated by resident cells is the goal of current biology-based strategies for regenerative dentistry. In this article, the bioactive potential of a simvastatin (SV)-releasing chitosan-calcium-hydroxide (CH-Ca) scaffold was assessed. After the incorporation of SV into CH-Ca, characterization of the scaffold was performed.

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The postlactational involution of the mammary gland is a complex process. It involves the collapse of the alveoli and the remodeling of the extracellular matrix, which in turn implies a complex set of interrelations between the epithelial, stromal, and extracellular matrix elements. The telocytes, a new type of CD34-positive stromal cell that differs from fibroblasts in morphological terms and gene expression, were detected in the stroma of several tissues, including the mammary gland; however, their function remains elusive.

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Background: Nandrolone decanoate (ND) is an anabolic-androgenic steroid, and its indiscriminate use leads to subclinical alterations in the hypothalamic-pituitary-gonadal axis and androgen-dependent organs.

Objectives: To evaluate the effects of ND, either alone or in combination with resistance exercise (RE), on the levels of sex hormones, converting enzymes, and steroid receptors and the morphology of the ventral prostate (VP) in adult and aged rats.

Methods: Forty Sprague-Dawley adult and aged rats were divided into four groups each, sedentary and trained with and without ND.

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This study evaluated the effect of cleaning protocols on the bond strength of resin cement to glass-ceramic. Ceramic specimens (N=120, n=12 per group) were etched with hydrofluoric acid and rinsed with water. After saliva contamination, specimens were cleaned as follows: water, 37% H3PO4, cleaning-paste (Ivoclean), or isopropanol.

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Postnatal development of Mongolian gerbil female prostate: An immunohistochemical and 3D modeling study.

Microsc Res Tech

May 2016

Department of Biology, Laboratory of Microscopy and Microanalysis, University of Estadual Paulista - UNESP, Rua Cristovão Colombo, São Jose do Rio Preto, São Paulo, Brazil.

The development of the prostate in male rodents, which involves complex epithelial-mesenchymal interactions between the urogenital sinus epithelium (UGE) and the urogenital sinus mesenchyme (UGM), has been deeply studied. In females, however, this process is not very clear. In this study, the postnatal development of the prostate in female Mongolian gerbils employing three-dimensional (3D) reconstructions, histochemical, and immunohistochemical techniques was characterized.

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In rodents, the final growth and maturation of the prostate occur at puberty, a crucial period for prostate development. The present study is a serological, morphological, morphometric, and immunohistochemical analysis of the effects of exposure to ethinylestradiol (EE) (15 µg/kg/day) during puberty (EE/PUB group) on the male ventral and female prostate in senile gerbils. In the study, male and female gerbils (Meriones unguiculatus) (42 days) received by gavage 15 μg/kg/day of EE (a component of the contraceptive pill), diluted in 100 µL of Nujol® for 1 week (EE/PUB group).

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Stress vulnerability during adolescence: comparison of chronic stressors in adolescent and adult rats.

Psychosom Med

November 2015

From the Laboratory of Pharmacology (Duarte, Planeta, Crestani), School of Pharmaceutical Sciences, University of Estadual Paulista-UNESP, Araraquara, SP, Brazil; Joint UFSCar-UNESP Graduate Program in Physiological Sciences (Duarte, Planeta, Crestani), São Carlos, SP, Brazil; and Behavioral Neuroscience Branch (Cruz, Leão), Intramural Research Program, National Institute on Drug Abuse, US National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland.

Article Synopsis
  • - This study examined how daily stress exposure affects cardiovascular function and physiological changes in adolescent versus adult rats, focusing on different types of stress (homotypic vs. heterotypic) and the long-term effects into adulthood.
  • - Results showed that adolescent rats exhibited more significant stress-related changes, like adrenal hypertrophy and hormone elevation, while both adolescent and adult rats experienced increased blood pressure and heart rate from stress exposure, with some responses being age-specific.
  • - The findings imply that adolescents are more vulnerable to the effects of stress, but many physiological changes observed during adolescence may reverse in adulthood, suggesting that early stress impacts adult health to a minimal extent.
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Aim: To assess the initial cytotoxicity and the late phenotype marker expression of odontoblast-like cells (MDPC-23) subjected to less aggressive in-office bleaching therapies.

Methodology: A 17.5% hydrogen peroxide (H2O2) gel was applied for 45, 15 or 5 min to enamel/dentine discs adapted to trans-wells positioned over cultured MDPC-23 cells.

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Objective. The aim of this study was to evaluate the physicochemical properties and bioactivity of two formulations of calcium silicate-based cements containing additives (CSCM) or resin (CSCR), associated with radiopacifying agents zirconium oxide (ZrO2) and niobium oxide (Nb2O5) as micro- and nanoparticles; calcium tungstate (CaWO4); and bismuth oxide (Bi2O3). MTA Angelus was used as control.

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Self-perception and oral health in pregnant adolescents.

Oral Health Dent Manag

September 2014

Department of Pediatric and Social Dentistry, Araçatuba. School of Dentistry University of Estadual Paulista - UNESP, José Bonifácio Street, 1193 - Araçatuba, SP, Brazil-16015-050. Tel: 55-18-3636 3249; Fax: 55-18-3636-3332; e-mail:

Objective: To evaluate the oral health indicators by determining the experience of dental caries and periodontal disease and identification of self-perceived oral health status of pregnant adolescents and to assess the association between the studied variables.

Materials And Methods: A transversal study, survey type and survey of the oral health status of 127 adolescents, 10-19 years of age, pregnant, accompanied by the Unified Health System of Araçatuba-SP was performed. The self-perceived oral health and socio-demographic data were recorded using an adapted questionnaire.

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The aim of the current review was to investigate the relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain. Substance P is a neuropeptide that is directly related with pain. In periodontal disease, it is expressed during the inflammatory process, and is one of the factors responsible for bone resorption.

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Purpose: This study evaluated the assumption that there are morphological differences between the natural anterior dentition of men and women. The goal of the study was to determine the gender of patients based on the appearance of the anterior teeth in photographs.

Materials And Methods: Laymen and observers from different specialties were asked to determine the gender of individuals based on the shape and arrangement of anterior teeth.

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The prognosis of tooth replantation is usually related to the need of endodontic treatment, which has a direct relationship with the occurrence of root resorptions. Several studies have been undertaken in an attempt to prevent, delay, or treat these complications, which are the main causes of loss of replanted teeth. This literature review examines research evidence on intracanal dressings and root canal filling materials used in cases of tooth replantation.

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