Astrocytes induce desynchronization and reduce predictability in neuron-astrocyte networks cultured on microelectrode arrays.

In this article, we aim to study how astrocytes control electrophysiological activity during neuronal network formation. We used a combination of spike/burst analysis, classification of spike waveforms based on various signal properties and tools from information theory to demonstrate how astrocytes modulate the electrical activity of neurons using microelectrode array (MEA) signals. We cultured rat primary cortical neurons and astrocytes on 60-electrode MEAs with different neuron/astrocyte ratios ranging from 'pure' neuronal cultures to co-cultures containing 50% neurons and 50% astrocytes.

The effect of trusting contexts in social dilemmas with collective and individual solutions.

Trust encourages members of communities to cooperate and provide public goods. However, the literature has yet to fully investigate how high and low trusting communities deal with collective action dilemmas with multiple solutions. The latter may raise the risk of coordination failure.

Tethered heme domains in a triheme cytochrome allow for increased electron transport distances.

Decades of research describe myriad redox enzymes that contain cofactors arranged in tightly packed chains facilitating rapid and controlled intra-protein electron transfer. Many such enzymes participate in extracellular electron transfer (EET), a process which allows microorganisms to conserve energy in anoxic environments by exploiting mineral oxides and other extracellular substrates as terminal electron acceptors. In this work, we describe the properties of the triheme cytochrome PgcA from Geobacter sulfurreducens.

Improving adverse drug event reporting by healthcare professionals.

Background: Adverse drug events, encompassing both adverse drug reactions and medication errors, pose a significant threat to health, leading to illness and, in severe cases, death. Timely and voluntary reporting of adverse drug events by healthcare professionals plays a crucial role in mitigating the morbidity and mortality linked to unexpected reactions and improper medication usage.

Objectives: To assess the effectiveness of different interventions aimed at healthcare professionals to improve the reporting of adverse drug events.

Sinusoidal LED light recipes can improve rocket edible biomass and reduce electricity costs in indoor growth environments.

Accumulation of edible biomass by crop plants relies on maintenance of a high photosynthetic rates across the photoperiod, with assimilation rate () generally responding to increasing light intensity in a hyperbolic fashion. In natural environments light fluctuates greatly over the course of the day, however in Controlled Environmental Agricultural (CEA) systems, light intensity can be supplemented or precisely controlled using LEDs to create near optimum conditions. In such indoor growth environments light is often delivered as a square wave and recommendations to horticulturalists are given in the form of Daily Light Integrals (DLI).

Neural changes in sign language vocabulary learning: Tracking lexical integration with ERP measures.

The present study aimed to investigate the neural changes related to the early stages of sign language vocabulary learning. Hearing non-signers were exposed to Catalan Sign Language (LSC) signs in three laboratory learning sessions over the course of a week. Participants completed two priming tasks designed to examine learning-related neural changes by means of N400 responses.

A Cross-Sectional Study of the Current and Future Dental Hygiene and Dental Therapy Student Workforce in the UK and Ireland During 2022-2025: Considering Facilitators and Barriers to the Growth of This Workforce.

Introduction: With evidence suggesting that dental hygienists (DH) and dental therapists (DThs) can undertake a significant proportion of routine clinical work, this paper explores the number of recent graduates and students currently in training in the UK and Ireland and considers whether there are sufficient DH and DTh registrants to positively impact on population needs.

Methods: An online questionnaire survey was distributed by the Directors of Dental Hygiene and Therapy Group to all programme leads of dental hygiene and dental therapy programmes during December 2023.

Results: There was a 100% response rate.

Research on ECG signal reconstruction based on improved weighted nuclear norm minimization and approximate message passing algorithm.

In order to improve the energy efficiency of wearable devices, it is necessary to compress and reconstruct the collected electrocardiogram data. The compressed data may be mixed with noise during the transmission process. The denoising-based approximate message passing (AMP) algorithm performs well in reconstructing noisy signals, so the denoising-based AMP algorithm is introduced into electrocardiogram signal reconstruction.

Internet self-efficacy moderates the association of information technology ability with successful ageing among older employees in three African samples.

The literature suggests that two distinct competencies [i.e., information technology ability (ITA), and internet self-efficacy] are necessary for the effective use of information technologies for successful ageing, but no study has examined the association of these skills on successful ageing and its domains (i.

A convolutional attention model for predicting response to chemo-immunotherapy from ultrasound elastography in mouse tumor models.

Background: In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may not benefit, leading to the varied efficacy observed in standard therapies. This study focuses on the prediction of tumor response to chemo-immunotherapy, exploring the potential of tumor mechanics and medical imaging as predictive biomarkers.

Judgments of learning (JOLs) impact item memory but not source memory: Insights into JOL reactivity using a multinomial model.

Past research has evaluated participants' understanding of their memory by soliciting judgments of learning (JOLs). Importantly, JOLs sometimes change memory for the judged material, leading to . The cue-strengthening account (Soderstrom et al.

Lower limb joint loading during high-impact activities: implication for bone health.

Osteoporosis results in low-trauma fractures affecting millions globally, in particular elderly populations. Despite the inclusion of physical activity in fracture prevention strategies, the optimal bone-strengthening exercises remain uncertain, highlighting the need for a deeper understanding of lower limb joint loading dynamics across various exercise types and levels. This study examines lower limb joint loading during high-impact exercises across different intensities.

A Matter of Memory? Age-Invariant Relative Clause Disambiguation and Memory Interference in Older Adults.

Past research suggests that Working Memory plays a role in determining relative clause attachment bias. Disambiguation preferences may further depend on Processing Speed and explicit memory demands in linguistic tasks. Given that Working Memory and Processing Speed decline with age, older adults offer a way of investigating the factors underlying disambiguation preferences.

Simulated Malaria Online Tool: an instrument for evaluating healthcare providers' practices and contributing to the evidence base for certifying malaria elimination and preventing its re-establishment.

Background: Healthcare providers (HCPs) practice and correct management of suspected malaria (CMSM) are central components of malaria elimination and prevention of re-establishment (POR) in countries in the elimination phase. However, knowledge of malaria surveillance systems and HCPs practices often wanes in countries aiming to eliminate malaria due to the low numbers of cases. The study aimed to implement a valid Simulated Malaria Online Tool (SMOT) for assessment HCP performance in CMSM and POR in a malaria-free area.

A narrative on the neurobiological roots of attachment-system functioning.

Attachment theory is one of the most comprehensive frameworks in social and developmental psychology. It describes how selective, enduring emotional bonds between infants and their caregivers are formed and maintained throughout life. These attachment bonds exhibit distinct characteristics that are intimately tied to fundamental aspects of mammalian life, including pregnancy, birth, lactation, and infant brain development.

Evaluation of Exercise Program for Overweight and Obese Pediatric Participants in a Single Tertiary Center in Singapore.

Purpose: Pediatric obesity is rising in prevalence. We audited the results of an exercise program for overweight and obese pediatric participants in a tertiary pediatric hospital. The main aim was to determine the program's effectiveness, with the main outcome of change in body mass index (BMI).

Investigating the links between questionable research practices, scientific norms and organisational culture.

Background: This study investigates the determinants of engagement in questionable research practices (QRPs), focusing on both individual-level factors (such as scholarly field, commitment to scientific norms, gender, contract type, and career stage) and institution-level factors (including industry type, researchers' perceptions of their research culture, and awareness of institutional policies on research integrity).

Methods: Using a multi-level modelling approach, we analyse data from an international survey of researchers working across disciplinary fields to estimate the effect of these factors on QRP engagement.

Results: Our findings indicate that contract type, career stage, academic field, adherence to scientific norms and gender significantly predict QRP engagement.

Psychological, psychosocial and physical barriers preventing nature-based intervention participation in adults with mental health disorders: A scoping review.

Nature-based interventions (NBIs) are becoming a common mental health care referral option; however, little is known about the barriers to participation. Research reveals a concentration of evidence on the practical barriers with a paucity of guidance on the personal barriers as experienced by service users. This review explores what is known on the psychological, psychosocial and physical barriers as disclosed by adult mental health service users and the various stakeholders involved in NBI.