Indicators associated with severity and mortality in hospitalized people with HIV: A retrospective cohort.

Objectives: to compare the sociodemographic and clinical severity indicators of hospitalized people with HIV in relation to clinical outcomes and urgent hospital admission.

Methods: a retrospective cohort study was conducted with 102 medical records of HIV-infected individuals hospitalized in a hospital in southern Brazil. In addition to descriptive analysis, Fisher's exact test, Pearson's Chi-square, and logistic regression were used.

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.

Introduction: This study aims to first discover plasma proteomic biomarkers relating to neurodegeneration (N) and vascular (V) damage in cognitively normal individuals and second to discover proteins mediating sex-related difference in N and V pathology.

Methods: Five thousand and thirty-two plasma proteins were measured in 1061 cognitively normal individuals (628 females and 433 males), nearly 90% of whom had magnetic resonance imaging measures of hippocampal volume (as N) and white matter hyperintensities (as V).

Results: Differential protein expression analysis and co-expression network analysis revealed different proteins and modules associated with N and V, respectively.

E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.

Multiple protein ubiquitination events at DNA double-strand breaks (DSBs) regulate damage recognition, signaling and repair. It has remained poorly understood how the repair process of DSBs is coordinated with the apoptotic response. Here, we identified the E4 ubiquitin ligase UFD-2 as a mediator of DNA-damage-induced apoptosis in a genetic screen in Caenorhabditis elegans.

Medical errors, incidents, accidents and violations.

Atul Gawande: 'The real problem isn't how to stop bad doctors from harming, even killing their patients. It's how to prevent good doctors from doing so.'A.

Ultrasonographic characterization of hepatic cryolesions. An ex vivo study.

Objective: To determine the physical basis for the ultrasonographic characteristics of the hepatic ice ball produced by cryotherapy and the size correlation between the actual hepatic ice ball and the ultrasonographic cryolesion.

Design: Experimental ex vivo study involving controlled freezing with liquid nitrogen recirculating probes of fresh porcine livers immersed in various solutions at ambient temperatures (20.2 degrees C to 22.