Psychosocial resilience surrounding age-typical losses among older adults in Sweden: group-based trajectories over a 25-year-period.

Introduction: Resilience is an important but often neglected aspect of healthy or successful aging. This study used a new approach for modelling psychosocial resilience to investigate responses when faced with age-typical losses. Rather than viewing resilience as a trait, we modelled trajectories of life satisfaction when faced with partner or functional loss in later life to identify resilient trajectories.

Durable improvements in atopic dermatitis in the head and neck and across other anatomic regions with rocatinlimab.

In a randomized phase 2b trial (NCT03703102) for adult patients with moderate-to-severe atopic dermatitis (AD), treatment with the T cell rebalancing anti-OX40 receptor antibody rocatinlimab (AMG 451/KHK4083) led to significant improvements in clinical measurements versus placebo including whole-body Eczema Area and Severity Index (EASI) score. AD manifestations can impact variable anatomic regions, and involvement of the head and neck, a sensitive, hard-to-treat area, can negatively impact quality of life. In this post hoc analysis, we investigated response to rocatinlimab treatment across anatomic regions, including the head and neck.

A Qualitative Exploration of Healthcare Workers' Experiences of End of Life Care for People With an Intellectual Disability.

Aim: To explore healthcare workers' experiences of end of life care for people with an intellectual disability.

Design: A descriptive qualitative study.

Method: Semi-structured interviews were conducted with 28 healthcare workers who cared for older people with an intellectual disability at their end of life.

Altered sleep and inflammation are related to outcomes in neonatal encephalopathy.

Aim: Immune dysregulation and delayed onset of sleep wake cycling (SWC) are associated with worse outcome in neonatal encephalopathy (NE), however the association between sleep and immune dysfunction in NE remains unclear. Aimed to evaluate association of sleep and systemic inflammation with outcomes in NE.

Methods: Amplitude-integrated electroencephalography (aEEG) recordings were collected on infants undergoing therapeutic hypothermia (TH).

MXene/WO Sensor Array with Improved SNN Algorithm for Accurate Identification of Toxic Gases.

Gas sensing is pivotal in critical areas such as industrial production and food safety. This study explores the gas classification capabilities of MXene-based gas sensors. Pure VCT MXene and an MXene/WO nanocomposite were synthesized, and MXene-based gas sensors were integrated into a 2 × 2 rudimentary electronic nose array.

Strategies for recruitment of adolescent girls into physical activity programmes: a systematic review protocol.

Background: Physical activity is essential for youth physical and mental health, yet just 15% of adolescent girls versus 22% of adolescent boys worldwide meet the World Health Organization guideline of 60 minutes of moderate-to-vigorous physical activity per day. As activity patterns established in adolescence often persist into adulthood, there is a looming risk of adverse health outcomes due to insufficient physical activity. A persistent challenge faced by physical activity providers, however, is recruiting adolescent girls into their programmes.

Computational design for enantioselective CO capture: asymmetric frustrated Lewis pairs in epoxide transformations.

Carbon capture and utilisation (CCU) technologies offer a compelling strategy to mitigate rising atmospheric carbon dioxide levels. Despite extensive research on the CO insertion into epoxides to form cyclic carbonates, the stereochemical implications of this reaction have been largely overlooked, despite the prevalence of racemic epoxide solutions. This study introduces an in silico approach to design asymmetric frustrated Lewis pairs (FLPs) aimed at controlling reaction stereochemistry.

Association of Upper Gastrointestinal Surgery of Great Britain and Ireland (AUGIS)/perioperative quality initiative (POQI) consensus statement on prehabilitation in oesophagogastric surgery.

Background: Prehabilitation is safe, feasible and may improve a range of outcomes in patients with oesophago-gastric cancer (OGC). Recent studies have suggested the potential of prehabilitation to improve body composition, sarcopenia and physical fitness, reduce surgical complications and improve quality of life. Despite this, prehabilitation services are not offered throughout all OGC centres in the UK.

A Structural and Functional Mimic of P680.

One or multiple chlorophyll a molecules are employed in the reaction center of photosystem II's main electron donor (defined as P680). We have a poor understanding of how the reaction center facilitates water oxidation in photosystem II and the roles that mono- and/or multimeric chlorophyll groups play when P680 oxidizes a neighboring tyrosine in order to drive water oxidation at the oxygen evolving complex. We have prepared a dimeric Mg-porphyrin complex [Mg(BTPP)] (1, H-BTPP=1,2-bis-(10,15,20-triphenylporphyrin-5-yl)-benzene) as a structural and functional mimic of the dimeric core of P680.

Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study.

Executive function deficits, common in psychiatric disorders, hinder daily activities and may be linked to diminished neural plasticity, affecting treatment and training responsiveness. In this pioneering study, we evaluated the feasibility and preliminary efficacy of psilocybin-assisted frontal-midline theta neurofeedback (NF), a neuromodulation technique leveraging neuroplasticity, to improve executive functions (EFs). Thirty-seven eligible participants were randomized into an experimental group ( = 18) and a passive control group ( = 19).

Conceptual Considerations for Understanding Resilience in Healthcare Students.

Aims: Increasing attention has been given to the concept resilience in the context of healthcare especially during and post the COVID pandemic. Much of the inquiry and evidence reported has focused on promoting or enhancing resilience in healthcare for improving the quality of care and reducing medical negligence. This discursive paper aims to highlight how resilience is conceptualised and identify any potential limitations or gaps in the context of healthcare students, acknowledging considerations for further development and research into this topic.

Effectiveness of Personalised Phone Calls and Short Message Service Reminders in Improving Patient Attendance at a Radiology Department.

Background: Patients missing scheduled hospital appointments pose significant challenges, including resource waste and delayed patient care. This study evaluated the effectiveness of personalised reminder systems (phone calls and short message service (SMS)) in improving patient attendance rates at a radiology department.

Methods: The study was conducted at a hospital facility in Saudi Arabia.

A lipidomic approach towards identifying the effects of fragrance hydroperoxides on keratinocytes.

Background: Limonene and linalool are used in cosmetic products for their floral scents, but their oxidation products are strong contact allergens whose mechanisms of action are still not fully understood.

Objectives: The effects of limonene hydroperoxide (Lim-2-OOH) and linalool hydroperoxides (Lin-6/7-OOH) on the lipid profile of a human keratinocyte cell line (HaCaT) were evaluated. 2,4-Dinitrofluorobenzene (DNFB) was also included.

The Psychosocial Impacts of Co-Designed Healing Gardens Among Aged Care Residents With and Without Dementia in Nigeria.

Healing gardens are green spaces that support the interaction of humans and elements of nature to improve well-being and quality of life. However, little is known about healing garden use and outcomes in African countries. This study aimed to design a healing garden intervention and measure its impact on psychosocial factors and quality of life of residents and care staff within two residential aged care facilities in Lagos, Nigeria.

Imitation of Multisyllabic Items by Children With Developmental Language Disorder: Evidence for Word-Level Atypical Speech Envelope and Pitch Contours.

Purpose: Developmental language disorder (DLD) is a multifaceted disorder. Recently, interest has grown in prosodic aspects of DLD, but most investigations of possible prosodic causes focus on speech perception tasks. Here, we focus on speech production from a speech amplitude envelope (AE) perspective.

Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.

Amyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures dysfunction in motor and cognitive networks in ALS. However, the longitudinal development of these dysfunctional patterns, especially in networks linked with cognitive-behavioural functions, remains unclear.

Enabling data linkages for rare diseases in a resilient environment with the SERDIF framework.

Environmental factors amplified by climate change contribute significantly to the global burden of disease, disproportionately impacting vulnerable populations, such as individuals with rare diseases. Researchers require innovative, dynamic data linkage methods to enable the development of risk prediction models, particularly for diseases like vasculitis with unknown aetiology but potential environmental triggers. In response, we present the Semantic Environmental and Rare Disease Data Integration Framework (SERDIF).

Minimum Tracking Linear Response Hubbard and Hund Corrected Density Functional Theory in CP2K.

We present the implementation of the Hubbard () and Hund () corrected Density Functional Theory (DFT + + ) functionality in the Quickstep program, which is part of the CP2K suite. The tensorial and Löwdin subspace representations are implemented and compared. Full analytical DFT + + forces are implemented and benchmarked for the tensorial and Löwdin representations.

Service Access and Supportive Care Experiences among Urban and Rural Cancer Survivors: Informing Social Work Practice.

Access to medical and supportive care services is important for the health and quality of life of cancer survivors; however, services are not always available or accessible to all survivors equally. This study aims to explore the experiences of cancer services among cancer survivors in urban and rural settings to inform social work practice. Authors conducted interviews with 25 cancer survivors (colorectal, n = 13; hematological, n = 12) in the West of Ireland, using a narrative inquiry approach.

Altmetric coverage of health research in Ireland 2017-2023: a protocol for a cross-sectional analysis.

Background: Scientific publications have been growing exponentially, contributing to an oversaturated information environment. Quantifying a research output's impact and reach cannot be solely measured by traditional metrics like citation counts as these have a lag time and are largely focused on an academic audience. There is increasing recognition to consider 'alternative metrics' or altmetrics to measure more immediate and broader impacts of research.