11,316 results match your criteria: "University of Doha for Science & Technology[Affiliation]"

The role of Interleukin 17 (IL17) in cancer: A systematic review.

Carcinogenesis

December 2024

Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.

Interleukin 17 (IL17) is a cytokine involved in immune regulation and has been increasingly recognized for its role in cancer progression. This systematic review aims to integrate data on IL17's role in various tumors to better understand its implications for cancer prognosis and treatment. The review included 105 studies (27.

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Background: Peak oxygen consumption (peak O) is traditionally scaled by body mass, but it is most appropriately scaled by fat-free mass. However, it is unknown whether peak O scaled by fat-free mass is associated with mortality and morbidity in people with a Fontan circulation. The aim of this study was to assess the associations between different expressions of peak O with mortality and morbidity in people with a Fontan circulation.

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Purpose: To assess whether corneal nerve analysis can identify and differentiate patients with multiple sclerosis (MS) from those with epilepsy.

Methods: Participants with MS (n = 83), participants with epilepsy (n = 50), and healthy controls (HCs) (n = 20) underwent corneal confocal microscopy (CCM) and quantification of automated corneal nerve fiber length (ACNFL), automated corneal nerve fractal dimension (ACNFrD), and ACNFrD/ACNFL ratio of the subbasal nerve plexus.

Results: ACNFL (MS: P < 0.

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Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.

Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.

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Purpose: Spina bifida (SB) arises from complex genetic interactions that converge to interfere with neural tube closure. Understanding the precise patterns conferring SB risk requires a deep exploration of the genomic networks and molecular pathways that govern neurulation. This study aims to delineate genome-wide regulatory signatures underlying SB pathophysiology.

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In the midst of a vast amount of scientific literature, the need for specific rules arise especially when it comes to deciding which impactful researchers should be nominated. These rules are based on measurable quantities that can easily be applied to a researcher's quantitative data. Various search engines, like Google Scholar, Semantic Scholar, Web of Science etc.

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Background And Aims: We aimed to assess the levels of hepatitis B and C knowledge, attitudes, and practices among medical students in Jordan. A survey included participation from medical students across all faculties in Jordan, from 2022 to 2023.

Methods: The data were analyzed with The R Statistical Software (v4.

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Cell division cycle 6 ​is an independent prognostic biomarker in breast cancer.

Pathology

November 2024

Nottingham Breast Cancer Research Centre, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham Biodiscovery Institute, University Park, Nottingham, UK; Pathology Department, Nottingham University Hospitals NHS Trust, Nottingham, UK; Pathology Department, Hamad Medical Corporation, Doha, Qatar. Electronic address:

Article Synopsis
  • CDC6 is a protein that plays a key role in cell division and cancer cell behavior, and this study examines its impact on breast cancer prognosis using large data sets from various cohorts.
  • High levels of CDC6 are linked to aggressive cancer traits, like larger tumors and negative hormone receptor status, suggesting that it might indicate a poorer patient outcome.
  • The findings support the idea that CDC6 could be a valuable prognostic factor and a potential target for breast cancer therapies, needing more research to explore its functional role.
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Article Synopsis
  • This study presents the first extensive report on Primary Myelofibrosis (PMF) in Qatar, covering data collected over 13 years, as there is a significant lack of information about PMF in the MENA region.
  • Findings show that pre-PMF patients differ from overt PMF patients in terms of blood counts and genetic features, with overt PMF having a higher risk category and worse disease progression.
  • The research provides important insights into the importance of the DIPSS plus scoring system, highlighting its effectiveness in identifying high-risk patients who face worse outcomes and increased treatment needs.
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Vanadium oxide-based compounds have attracted significant interest as battery materials, especially in aqueous Zn-ion batteries, due to favorable properties and compatibility in Zn-ion systems. In a simple hydrothermal method with moderate conditions, a novel vanadium oxide compound has been synthesized using ammonium metavanadate with oxalic acid as a reducing agent. Various characterization techniques confirmed the formation of layered VO(HO) nanoplatelets with a tetragonal crystal structure.

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Background: Traumatic brain injury (TBI) poses significant health challenges, often leading to complications such as venous thromboembolism (VTE) and increased mortality rates. The administration of early post-traumatic prophylaxis (PTP) is intended to mitigate these risks and enhance overall patient recovery. This study aims to perform a systematic review and meta-analysis assessing clinical outcomes associated with early versus late pharmacologic thromboprophylaxis in TBI patients.

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Introduction: Psoriasis is a systemic inflammatory disease associated with elevated cardiovascular risk due to inflammatory and oxidative stress. Two-dimensional speckle-tracking echocardiography (2D-STE) can detect both regional and global myocardial strain. Impairment of ventricular strain can assist in the early detection of myocardial dysfunction.

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Objectives: Genital herpes simplex virus (HSV) type 1 and 2 infections are lifelong and can cause symptomatic genital ulcer disease (GUD). HSV-2 almost always causes sexually transmitted genital infection, while HSV-1 mainly causes oral infection but can be sexually transmitted to cause genital infection. This study estimated genital infection with both HSV types and associated GUD globally in 2020, breaking down the data by WHO region and sex for females and males.

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Background: Inadequate maternal dietary intakes remain a public health challenge in low-income countries like Malawi and can cause adverse birth outcomes.

Objectives: To improve maternal dietary intakes and thus reduce the prevalence of adverse birth outcomes in rural Malawi.

Methods: We performed a 2-armed (1:1) cluster-randomized controlled trial in Southern Malawi, enrolling pregnant women at gestational age 12-18 wk.

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This study aimed to investigate the characteristics of composite scaffolds that combine fibroin derived from spider silk and carboxymethyl cellulose (CMC) in the field of bone tissue engineering. Fibroin, obtained from spider silk, serves as a valuable biomaterial and constitutes the primary component of fibrous protein-based spider silk threads. To enhance the binding efficiency in bone formation after scaffold implantation, CMC was integrated into fibroin, aiming to improve the injectability properties of the scaffold in bone substitutes.

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Purpose: Posterior ankle Impingement (PAI) is a condition commonly affecting athletes and individuals engaged in activities involving repetitive ankle plantar flexion. This study aimed to evaluate the impact of nonsurgical management, excluding corticosteroid injections, on the functional outcomes of football players diagnosed with PAI.

Materials And Methods: Twenty male football Players between age group of 18-30 years, clinically diagnosed of PAI, were included in this longitudinal study.

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Background And Aims: Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective.

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A search is reported for charge-parity violation in decays, using data collected in proton-proton collisions at recorded by the CMS experiment in 2018. The analysis uses a dedicated data set that corresponds to an integrated luminosity of 41.6 , which consists of about 10 billion events containing a pair of b hadrons, nearly all of which decay to charm hadrons.

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Article Synopsis
  • Climate change is causing shifts in animal habitats, particularly affecting the distribution of threatened marine species like whale sharks.
  • Projections indicate that by 2100, whale sharks could lose more than 50% of their core habitat in some areas, with significant geographic shifts that could place them in closer proximity to large ships.
  • The increase in whale shark interaction with shipping is expected to be dramatically higher under high emission scenarios compared to sustainable development, highlighting the urgency for better climate-threat predictions in conservation strategies for endangered marine life.
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Article Synopsis
  • Rapid advancements in IoT are significantly impacting the vehicle industry, leading to a demand for better decision-making methods for selecting maritime vehicles.
  • This research presents a combined multi-criteria decision-making framework that integrates the additive ratio assessment (ARAS) and analytic hierarchy process (AHP) to evaluate performance and authenticity criteria for IoT-based maritime vehicles.
  • The hybrid approach enhances the assessment process by addressing the limitations of AHP, offering a more comprehensive evaluation of alternatives, validated through empirical data and expert judgment.
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Implementing federated learning over VPN-based wireless backhaul networks for healthcare systems.

PeerJ Comput Sci

November 2024

Department of Computer System & Technology, Faculty of Computer Science & Information Technology, Universiti Malaya, Kuala Lumpur, Malaysia.

Federated learning (FL) is a popular method where edge devices work together to train machine learning models. This study introduces an efficient network for analyzing healthcare records. It uses VPN technology and applies a federated learning approach over a wireless backhaul network.

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Unveiling the nexus: The tumor microenvironment as a strategic frontier in viral cancers.

Cytokine

January 2025

Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 5000, Nova Gorica, Slovenia.

Viral infections are a significant factor in the etiology of various cancers, with the tumor microenvironment (TME) playing a crucial role in disease progression. This review delves into the complex interactions between viruses and the TME, highlighting how these interactions shape the course of viral cancers. We explore the distinct roles of immune cells, including T-cells, B-cells, macrophages, and dendritic cells, within the TME and their influence on cancer progression.

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Beyond fat: Does semaglutide affect lean mass?

Clin Nutr

December 2024

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Article Synopsis
  • The paper discusses the effects of semaglutide, a GLP-1 receptor agonist, particularly focusing on its influence on lean mass in addition to its weight loss benefits.
  • While some studies show that semaglutide leads to a reduction in both lean and fat mass, others indicate an increase in lean mass relative to total body mass.
  • The mixed results highlight the need for further research, especially given the increasing use of semaglutide in treatments.
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