Disease evidence for IGFBP-2 as a key player in prostate cancer progression and development of osteosclerotic lesions.

Accumulating evidence indicates that alterations in the IGF axis contribute to the development of chemo- and radio-resistant, advanced-stage cancers. Additionally, they contribute to hormonal insensitivity in adenocarcinomas such as those derived from prostate and breast. The ligands, IGF-I and IGF-II, along with their receptors, IGF-IR and IGF-IIR, have been implicated in a wide range of disease.

The adenine pocket of a single catalytic site is derivatized when the bovine heart mitochondrial F1-ATPase is photoinactivated with 4-amino-1-octylquinaldinium.

The bovine heart mitochondrial F1-ATPase (MF1) is reversibly inhibited in the dark by 4-amino-1-octylquinaldinium (AOQ) with an I0.5 value of 48 microM. When irradiated in the presence of AOQ, MF1 is photoinactivated with an apparent Kd of 12 microM.

Effects of perceiving and imagining scenes on memory for pictures.

Boundary extension is the tendency to remember having seen a greater expanse of a scene than was shown. Four experiments tested whether a picture must depict a partial view of a scene for the distortion to occur. The premise was that partial views activate a perceptual schema, a representation of the expected scene structure outside the view.