A meta-synthesis of the cycle of financial strain, coping behaviors and health outcomes across the life course.

Background: The lived experience and impact of financial strain on broad physical and mental health outcomes is important and yet underexplored. Improving our depth of understanding of the relationship between financial strain and health may offer important insights to address this complex phenomenon.

Objective: The primary objective of this study was to conduct a meta-synthesis of existing qualitative literature that investigated or described the relationship between financial strain and health outcomes.

"The PO-Driven Model": A Basic Science Pipeline for the Bioeconomy with Solutions Inspired by Convergent Evolution for Connecting Parallel Research Ideas.

Basic science research, also called "curiosity-driven research," is fundamental work done with no immediate economic goals but rather a focus on discovery for discovery's sake. However, basic science research is often needed to seed more applied, economically-oriented, research. Both basic and applied research efforts are important aspects of the "bioeconomy" defined here as the contributions to the overall economy from various biology-related fields spanning everything from museum-based natural history research to agricultural food and material production to healthcare.

How will developmental neuroimaging contribute to the prediction of neurodevelopmental or psychiatric disorders? Challenges and opportunities.

Successful developmental neuroimaging efforts require interdisciplinary expertise to ground scientific questions in knowledge of human development, modify and create technologies and data processing pipelines suited to the young brain, and ensure research procedures meet the needs and protect the interests of young children and their caregivers. This paper brings together four interdisciplinary perspectives to tackle a set of questions that are central for the field to address as we imagine a future role for developmental neuroimaging in the prediction of neurodevelopmental or psychiatric disorders: 1) How do we generate a strong evidence base for causality and clinical relevance? 2) How do we ensure the integrity of the data and support fair and wide access? 3) How can these technologies be implemented in the clinic? 4) What are the ethical obligations for neuroimaging researchers working with infants and young children?

Implementation of the RQI System: Baseline Skills and Self-Report Competence and Confidence Data From 12 NLN Inaugural Change Agent Nursing Programs.

Aim: This article describes the implementation, baseline cardiopulmonary resuscitation (CPR) skills, and competence and confidence in skills of participants in 12 nursing programs piloting the Resuscitation Quality Improvement (RQI) program. Of 1,847 participants, 175 had not previously completed a CPR course.

Method: Schools could choose the sequence for completing baselines skills and required e-learning modules.

Draft genome sequence of the marine halophile strain 3098.

Vibrio diabolicus 3098 is a marine halophile, a member of the . The draft whole-genome sequence is 5.17 Mb and has 4,829 predicted coding sequences divided into two chromosomes and a plasmid.

enCompass: evaluation of a community-based substance use disorder stigma intervention.

Introduction: Stigma within communities is pervasive and a barrier to substance use disorder (SUD) treatment. The current proof-of-concept study evaluated , a community-based SUD knowledge and stigma intervention.

Methods: In 2021, 22 trainings were offered to community members in partnership with the Ohio Governor's RecoveryOhio initiative to 22 Ohio counties with high numbers of overdose deaths.

Targeting quorum sensing for manipulation of commensal microbiota.

Bacteria communicate through the accumulation of autoinducer (AI) molecules that regulate gene expression at critical densities in a process called quorum sensing (QS). Extensive work using simple systems and single strains of bacteria have revealed a role for QS in the regulation of virulence factors and biofilm formation; however, less is known about QS dynamics among communities, especially in vivo. In this review, we summarize the diversity of QS signals as well as their ability to influence "non-target" behaviors among species that have receptors but not synthases for those signals.

Navigating motherhood: biological and landscape factors affecting postpartum movement in white-tailed deer.

Background: Population growth and management in cervid species is dependent on reproductive ecology and factors influencing juvenile survival. Aspects of the female's movement behavior likely affect juvenile survival and movement patterns of pregnant and lactating females differ from non-pregnant or non-lactating females. Explanations for these differing movement patterns include change in nutritional demands for the female, isolation during parturition, and predator avoidance.

Electricity use in big area additive manufacturing of fiber-reinforced polymer composites.

In recent years, additive manufacturing (AM), especially large-format additive manufacturing (LFAM), has gained momentum in the manufacturing industry. While LFAM offers benefits over conventional manufacturing processes, such as minimizing material waste and providing vast geometric freedom, assessing its sustainability remains challenging due to limited data, particularly on energy consumption. Most existing data pertain to small-scale or desktop AM and are not directly applicable to LFAM.

Transcriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton's tyrosine kinase expression levels.

Historically, CLL prognostication relied on disease burden, reflected in clinical stage. Later, chromosome abnormalities and genomics suggested several CLL subtypes which were aligned with response to therapy. Gene expression profiling data identified pathways associated with CLL progression.

Boundaries on a binge: Explicating the role of intentionality in binge-watching motivations and problematic outcomes.

Binge-watching is often studied in research, and discussed in lay writings, under the assumption that it is a maladaptive and problematic behavior. However, as with all media use, there are circumstances in which binge-watching may be functional for an individual. This paper explores the role of intentionality-defined as the extent to which a viewing session was planned and executed as planned-in differentiating problematic from unproblematic binge-watching behavior.

Engineering plant biosensors: recent advances in design and applications.

Plants have evolved sophisticated molecular switches to perceive and respond to both endogenous and exogenous signals, enabling changes in form and function in response to environmental and developmental cues. As autotrophic, multicellular organisms, plants represent promising platforms for designing and engineering sense-and-report modules. Advances in protein engineering and functional screening have facilitated the reprogramming of native switches into biosensors capable of detecting novel small molecules.

Long-Term Stable Reference Electrodes with High-Pressure Tolerance and Salinity-Independence.

The reference electrode's performance is essential for ensuring the accuracy of electrochemical sensors in marine environments. Yet, the many existing reference electrodes can exhibit sensitivity to salinity variations, potentially leading to inaccuracies in the measurement process. Herein, we have designed a reliable solid-state reference electrode by introducing SiO-stabilized 1-methyl-3-octylimidazolium bis(trifluoromethyl sulfonyl)imide ([Cmim] [Ntf]) into a P(VdF--HFP) matrix with a SPEEK/[Cmim] [Ntf] coated Ag/AgCl as substrate.

The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn's Disease.

Introduction: Bowel urgency has recently been recognized as a Crohn's disease (CD) symptom that substantially impacts patients' quality of life. The Urgency NRS is a single-item patient-reported outcome measure assessing bowel urgency severity in the past 24 h (0-10 scale). We aimed to evaluate the psychometric properties of the Urgency Numeric Rating Scale (NRS) in adults with moderately to severely active CD and to estimate thresholds for meaningful improvement and bowel urgency remission.

Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography.

To better understand host cell protein (HCP) retention in adeno-associated virus (AAV) downstream processes, sequential window acquisition of all theoretical fragment ion mass spectra (SWATH-MS) was used to quantitatively profile residual HCPs for four AAV serotypes (AAV2, -5, -8, and -9) produced with HEK293 cells and purified using POROS CaptureSelect AAVX affinity chromatography. A broad range of residual HCPs were detected in affinity eluates after purification (  = 2,746), and HCP profiles showed universally present species (  = 1,117) and species unique to one or more AAV serotype. SWATH-MS revealed that HCP persistence was dominated by high-abundance conserved species (HACS), which appeared across all serotype conditions studied.

Trauma-related moderators of associations between sex hormones and PTSD symptoms: a replication-extension.

Post-traumatic stress disorder (PTSD) disproportionately affects women and recent evidence suggests that unique associations between sex hormones (e.g. estradiol and progesterone) and PTSD symptoms may contribute to this difference.

Behavior of chemically powered Janus colloids in lyotropic chromonic liquid crystal.

Platinum-coated Janus colloids exhibit self-propelled motion in aqueous solution via the catalytic decomposition of hydrogen peroxide. Here, we report their motion in a uniformly aligned nematic phase of lyotropic chromonic liquid crystal, disodium cromoglycate (DSCG). When active Janus colloids are placed in DSCG, we find that the anisotropy of the liquid crystal imposes a strong sense of direction to their motion; the Janus colloids tend to move parallel to the nematic director.

Synthesis of evidence yields high social cost of carbon due to structural model variation and uncertainties.

Estimating the cost to society from a ton of CO-termed the social cost of carbon (SCC)-requires connecting a model of the climate system with a representation of the economic and social effects of changes in climate, and the aggregation of diverse, uncertain impacts across both time and space. A growing literature has examined the effect of fundamental structural elements of the models supporting SCC calculations. This work has accumulated in a piecemeal fashion, leaving their relative importance unclear.

Assessing age-related changes in brain activity during isometric upper and lower limb force control tasks.

Despite the widespread use of older adults (OA) as controls in movement disorder studies, the specific effects of aging on the neural control of upper and lower limb movements remain unclear. While functional MRI paradigms focusing on hand movements are widely used to investigate age-related brain changes, research on lower limb movements is limited due to technical challenges in an MRI environment. This study addressed this gap by examining both upper and lower limb movements in healthy young adults (YA) vs.

Quantifying Long-Time Hydrogen-Deuterium Exchange of Bovine Serum Albumin with Hydrogen-Deuterium Exchange Small-Angle Neutron Scattering.

Hydrogen-deuterium exchange (HDX) measured by small-angle neutron scattering (HDX-SANS) is used to measure HDX in bovine serum albumin (BSA) under different temperatures and formulation conditions. HDX-SANS measurements are performed at 40, 50, and 60 °C in DO after storing proteins at 4 °C for 1 week to pre-exchange the readily accessible hydrogens. This enables us to probe the long-time HDX of protons at the core of the BSA proteins, which is more challenging for solvent molecules to access.

Minimum Electromyography Sensor Set Needed to Identify Age-Related Impairments in the Neuromuscular Control of Walking Using the Dynamic Motor Control Index.

The dynamic motor control index is an emerging biomarker of age-related neuromuscular impairment. To date, it has been computed by quantifying the co-activity of eleven lower limb muscles. Because clinics that routinely employ electromyography typically collect from fewer muscles, a reduced muscle sensor set may improve the clinical usability of this metric of motor control.

Prevalence of Internet Gaming Disorder, Depression, and Anxiety Symptoms Before and After the Pandemic.

"Internet gaming disorder" (IGD) is a condition for further study in the DSM-5, with its prevalence estimated to be anywhere from 0.7% to 27.5% depending on the methodology used to measure it.

Multifaceted concussion assessment battery: sensitivity at the expense of specificity?

Objectives: A multifaceted assessment battery is recommended for testing suspected concussed athletes; however, the individual tests have limitations and potentially may lead to false positive outcomes. Therefore, the purpose of this study was to psychometrically evaluate concussion assessment tools used for intercollegiate student-athletes, with a focus on the time interval between baseline and subsequent assessments.

Methods: Ninety-two collegiate student-athletes matched between concussion ( = 46.