The Heart is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect.

The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new perspectives and address several critical issues in this review. () The Frank-Starling mechanism and Anrep effect are dynamically linked and act synergistically.

Evaluating the impact of financial worry on mental health: a cross-sectional study among Kenyan radiographers.

Background: Psychological distress is a major public health concern that has many influencing factors. One of them is the financial capability of an individual. Despite the integral role of radiographers in healthcare delivery, there is limited literature about radiographers in Kenya and more so regarding their mental well-being.

Transforming nursing work environments: the impact of organizational culture on work-related stress among nurses: a systematic review.

Background: Creating a healthy and conducive nursing work environment is a universal global nursing concern. Work-Related Stress, global nursing and a public health problem that has continued to bedevil the world healthcare systems is of a particular interest. It has not only compromised the quality of patient care but also negatively impacted nurses' quality of work life and adversely affected global healthcare management.

Gridded, temporally referenced spatial information on soil organic carbon for Hungary.

Soil organic carbon (SOC), known as the most important soil attribute, affects various soil functions and services, essential for nutritious food and clean drinking water. Since recognizing its key role in many environmental challenges, there has been an increasing demand for spatial information on SOC. Our objective is to present the results of a mapping activity aimed at producing spatially exhaustive information on SOC content, density, and stock for the topsoils of Hungary for 1992 and 2000.

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Background: The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors indicating the need for adequately tuning CAR T cell functionality.

Methods: We leveraged a translational pipeline including biophysical characterization and structural prediction of the CAR binding moiety, evaluation of cellular avidity, synapse formation, T cell motility, and functional capacities under repetitive target challenge and in sustained tumor control.

Results: As an example of clinical relevance, we derived a panel of anti-Her2 CARs covering a 4-log affinity range, all expected to target the same Her2 epitope.

Fermentative production of vitamin B by and and its promising health benefits: A review.

Cobalamin, generally known as vitamin B, is a crucial component required for humans in several physiological processes. It has been produced from sources that are derived from animals, making it difficult for vegetarians and vegans to consume the recommended amount each day. The importance of vitamin B in red blood cell production, DNA synthesis, and brain processes has been highlighted.

Exploring the current provision of pancreatic transplantations in low- and middle-income countries: Current landscape, challenges, future prospects.

This comprehensive review addresses the global health challenge of disparities in pancreas transplant access, particularly in low- and middle-income countries (LMICs) compared to high-income countries. Despite advancements in surgical techniques and immunosuppression for procedures like simultaneous pancreas-kidney, pancreas-after-kidney, and pancreas-transplant alone, LMICs face significant challenges, including limited infrastructure, financial constraints, and a shortage of skilled medical professionals. Donation after brain death remains constrained by sociocultural barriers.

Upgrading Right Ventricular Pacing to Cardiac Resynchronization in HFrEF Patients Improves Symptoms and Functional Outcomes.

Background: In the BUDAPEST (Biventricular Upgrade on left ventricular reverse remodeling and clinical outcomes in patients with left ventricular Dysfunction and intermittent or permanent APical/SepTal right ventricular pacing)-CRT Upgrade randomized trial, the authors have demonstrated improved mortality and morbidity after cardiac resynchronization therapy (CRT) upgrade in patients with heart failure with reduced ejection fraction (HFrEF) with high right ventricular (RV) pacing burden.

Objectives: This substudy sought to examine the impact of CRT upgrade on symptoms, functional outcome, and exercise capacity.

Methods: In the BUDAPEST-CRT Upgrade trial, 360 HFrEF patients with pacemaker or implantable cardioverter-defibrillator (ICD) and ≥20% RV pacing burden were randomly assigned (3:2) to cardiac resynchronization therapy with defibrillator (CRT-D) upgrade (n = 215) or ICD (n = 145).

Reversible stochastic epigenetic like silencing of the production of pulcherriminic acid in the antimicrobial antagonist Metschnikowia Pulcherrima.

The ability to produce pulcherriminic acid is a characteristic feature of yeast species of the pulcherrima clade recently merged under the taxonomic name Metschnikowia pulcherrima. This iron chelator cyclodipeptide forms pulcherrimin, a maroon-red pigment with ferric ions. Its synthesis and secretion into the environment is under the control of closely linked genes referred to as the PUL cluster.

Testing a biexponential kinetic model for the heterogeneous isotopic exchange of phosphate ions on several types of soil.

In this study, a new kinetic equation was applied for the heterogeneous isotopic exchange of phosphate ions on soil. Phosphate sorption on chernozem, marshy meadow and meadow soil was studied by P-32 heterogeneous isotopic exchange in steady-state. The soil samples were incubated with 5 different amounts of KHPO for 1, 3, 13, 10, 12 and 22 weeks.

Topographical variations in the skin barrier and their role in disease pathogenesis.

The skin barrier can be divided into at least four functional units: chemical, microbial, physical and immunological barriers. The chemical and microbial barriers have previously been shown to exhibit different characteristics in topographically distinct skin regions. There is increasing evidence that the physical and immunological barriers also show marked variability in different areas of the skin.

Assessing the factors affecting the accessibility of primary dental care for people with haemophilia.

Introduction: Patients with haemophilia (PWH) often have difficulty accessing dental services.

Aim: To determine the accessibility of dental care for PWH and to examine their perceptions of how coronavirus type-2 (CoV-2) disease (COVID-19) has affected their ability to access dental treatments following the pandemic.

Methods: The questionnaire survey was conducted between July 2022 and December 2022 at haemophilia treatment centres in Hungary.

From Waste to Worth: Using Fermented Orange Pomace in Sustainable Feed Production.

Modern agriculture faces the dual challenge of producing environmentally friendly feed while minimizing chemical fertilizers and energy use. This study evaluates the use of orange pomace fermentation liquor (OPFL) as a bio-fertilizer to enhance the growth and nutritional content of sprouted barley for sustainable feed production. We conducted multiple assays to determine OPFL's growth-promotion potential, including in vitro phosphate solubilization, indole-3-acetic acid (IAA) production, biofilm formation, and antimicrobial effects.

Sustainable Wheat Cultivation in Sandy Soils: Impact of Organic and Biofertilizer Use on Soil Health and Crop Yield.

Sandy soils are widespread globally and are increasingly utilized to meet the demands of a growing population and urbanization for food, fiber, energy, and other essential services. However, their poor water and nutrient retention makes crop cultivation challenging. This study evaluated the effects of integrating compost and plant growth-promoting rhizobacteria (PGPR; SWERI 111 and OR512393) on wheat ( L.

A Novel Solid Media-Free In-Planta Soybean (. (L) Merr.) Transformation Approach.

Soybean's lengthy protocols for transgenic plant production are a bottleneck in the transgenic breeding of this crop. Explants cultured on a medium for an extended duration exhibit unanticipated modifications. Stress-induced somaclonal variations and in vitro contaminations also cause substantial losses of transgenic plants.

Prognostic Role of Invasion-Related Extracellular Matrix Molecules in Diffusely Infiltrating Grade 2 and 3 Astrocytomas.

Background: Astrocytoma, an IDH-mutant is a common primary brain tumor. Total surgical resection is not feasible due to peritumoral infiltration mediated by extracellular matrix (ECM) molecules.

Methods: This study aimed at determining the expression pattern of ECM molecules in different prognostic groups of WHO grade 2 and grade 3 patients and identifying the effect of onco-radiotherapy on tumor cell invasion of grade 3 patients.

Development of Body Weight Management Among the Hungarian Population.

Background/objectives: Nowadays, body weight management has gained significant consumer attention due to the health megatrend. It plays a key role in preventing diseases, maintaining health, and creating a balanced diet, as well as in mental and physical health. Overweight and obesity are serious problems that can result in various non-communicable diseases; thus, managing the body weight of those who are overweight or obese without pathological changes would help reduce the prevalence of these diseases.

Inequalities and Differences in Health Status of Pre- and Perinatal Periods in Hungarian Long-Term Series Analysis (1997-2019).

Objectives: The main goal of this study is to publish findings on the lifestyle factors of pregnant women in Hungary and their impact on early childhood health status by examining changes over time and regional/geographical disparities.

Methods: The source of the data is the raw indicators reported by health visitors as per mandatory annual report data for the period of 1997-2019. To examine the association, we used indicators of pregnant women's states as explanatory variables (for example, pregnant women in very late care, prenatal smoking habits, and pregnant women without care), and the outcome indicators were prematurity, intrauterine malnutrition, and newborn babies with developmental disorders.

Inhibition of K Channels Affects the Target Cell Killing Potential of CAR T Cells.

Ion channels of T cells (Kv1.3, KCa3.1, and CRAC) participate in the regulation of activation and effector functions via modulation of the Ca-dependent pathway.