Genotype-dependent resilience mediated by melatonin in sweet corn.

Background: Water deficits, exacerbated by climate change and unpredictable weather, have become a significant global challenge to agricultural productivity. In this context, exogenous melatonin treatment is well documented as a stress alleviator; however, its effects on various biological processes, particularly in less-explored genotypes, remain understudied. This study aimed to enhance water deficit resilience in sweet corn by applying foliar melatonin to four genotypes-Messenger, Dessert, Royalty, and Tyson under two levels of water deprivation induced by polyethylene glycol at 8% and 12% concentrations in a hydroponic, controlled environment.

isolated from septic pleuritis in a horse.

Here we report the isolation of from a thoracic sample from a horse. A 17-y-old Hungarian Sport Horse mare was referred to the equine clinic of the University of Veterinary Medicine Budapest, Hungary, with suspected pleuritis. Upon arrival, the horse was febrile and had tachycardia, severe inspiratory dyspnea, and tachypnea.

Impact of Dipole Self-Energy on Cavity-Induced Nonadiabatic Dynamics.

The coupling of matter to the quantized electromagnetic field of a plasmonic or optical cavity can be harnessed to modify and control chemical and physical properties of molecules. In optical cavities, a term known as the dipole self-energy (DSE) appears in the Hamiltonian to ensure gauge invariance. The aim of this work is twofold.

Revitalizing Soybean Plants in Saline, Cd-Polluted Soil Using Si-NPs, Biochar, and PGPR.

Excessive irrigation of saline-alkaline soils with Cd-contaminated wastewater has resulted in deterioration of both soil and plant quality. To an investigate this, a study was conducted to explore the effects of biochar (applied at 10 t ha), PGPRs ( (USDA 110) + at 1:1 ratio), and Si-NPs (25 mg L) on soybean plants grown in saline-alkali soil irrigated with wastewater. The results showed that the trio-combination of biochar with PGPRs, (as soil amendments) and Si-NPs (as foliar spraying), was more effective than individual or coupled applications in reducing Cd bioavailability in the soil, minimizing its absorption, translocation and bioconcentration in soybean tissues.

Accumulation of Microplastics and Potentially Toxic Elements in Plant Leaves Along an Urbanization Gradient in Bangladesh.

Potentially toxic elements (PTEs) and microplastics (MPs) in the atmosphere raise widespread apprehension due to their association with the ecosystem and public health. The accumulation of airborne MPs and PTEs was analyzed in leaves, and the Pollution Index (PI) was calculated along an industrial, residential, and rural gradient in Bangladesh. Only polyethylene terephthalate (PET) was found in the highest concentration in industrial areas compared to other areas.

Evaluation of the Nutritional Impact of Baobab Leaves ( L.) as a Dietary Intervention to Combat Nutrient Deficiencies and Poverty-Related Health Problems.

Background/objectives: Baobab ( L.) is an underutilized species and edible parts (fruits, leaves and seeds) contribute to food security and human health in tropical areas. Although the fruits have attracted greater research interest and have recently been approved for consumption in EU countries, the leaves are traditionally consumed but they have yet to be studied from an interventional perspective.

Safety and Efficacy of Loading Doses of Vitamin D: Recommendations for Effective Repletion.

Epidemiological data on vitamin D status revealed that, despite various dosage and durations of supplementation, the effectiveness often fails to achieve optimal outcomes. The need for higher doses than previously recommended was suggested, but several modifying factors should be considered, including the level of deficiency, and BMI. The objectives of this post hoc evaluation are to characterize treatment effectiveness based on the applied dose, duration and BMI; and to assess the safety aspects associated with rapid repletion of vitamin D.

Synthesis and Characterization of Novel Co(III)/Ru(II) Heterobimetallic Complexes as Hypoxia-Activated Iron-Sequestering Anticancer Prodrugs.

Heterobimetallic complexes of an ambidentate deferiprone derivative, 3-hydroxy-2-methyl-1-(3-((pyridin-2-ylmethyl)amino)propyl)pyridin-4(1H)-one (PyPropHpH), incorporating an octahedral [Co(4N)] (4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa)) and a half-sandwich type [(η--cym)Ru] (-cym = -cymene) entity have been synthesized and characterized by various analytical techniques. The reaction between PyPropHpH and [Co(4N)Cl]Cl resulted in the exclusive (O,O) coordination of the ligand to Co(III) yielding [Co(tren)PyPropHp](PF) () and [Co(tpa)PyPropHp](PF) (). This binding mode was further supported by the molecular structure of [Co(tpa)PyPropHp](ClO)(OH)·6HO () and [Co(tren)PyPropHpH]Cl(PF)·2HO·CHOH (), respectively, obtained via the slow evaporation of the appropriate reaction mixtures and analyzed using X-ray crystallography.

Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics.

Vulnerable atherosclerotic plaques, especially hemorrhaged lesions, are the major cause of mortalities related to vascular pathologies. The early identification of vulnerable plaques helps to stratify patients at risk of developing acute vascular events. In this study, proteomics analyses of human carotid artery samples collected from patients with atheromatous plaques and complicated lesions, respectively, as well as from healthy controls were performed.

Genomic Variability Survey in L., with Reference to Four Insular Populations from Eastern Europe.

Cosmopolitan in the western areas of Europe as well as on other continents, the Ilex genus is interesting for its genetic, phenotypic, and biogeographic variabilities. Its insular/local distribution, according to existing data on the periphery of the central and southern European areas, represents a suitable case study with reference to the adaptive plasticity or acclimatization of the L. species to new climatic conditions.

Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy.

Diabetic sensorimotor neuropathy (DSPN) is strongly associated with the extent of cellular oxidative stress and endothelial dysfunction in type 2 diabetes (T2DM). Alpha-lipoic acid (ALA) attenuates the progression of DSPN through its antioxidant and vasculoprotective effects. Kallistatin has antioxidant and anti-inflammatory properties.

Novel Molecular Classification of Breast Cancer with PET Imaging.

Breast cancer is a heterogeneous disease characterized by a wide range of biomarker expressions, resulting in varied progression, behavior, and prognosis. While traditional biopsy-based molecular classification is the gold standard, it is invasive and limited in capturing tumor heterogeneity, especially in deep or metastatic lesions. Molecular imaging, particularly positron emission tomography (PET) imaging, offering a non-invasive alternative, potentially plays a crucial role in the classification and management of breast cancer by providing detailed information about tumor location, heterogeneity, and progression.

Impact of Diabetes on Excessive Cardiovascular Risk: Matched Analysis Based on the European Health Interview Survey.

: Diabetes represents a major public health challenge due to its strong link to cardiovascular risk, therefore the aim was to explore the excessive cardiovascular risk attributed to diabetes. : This cross-sectional study was based on data from the European Health Interview Surveys in Hungary. Propensity score matching was used to control confounding factors including age, gender, education, marital status, income, health status, obesity, smoking, place of residence, and physical activity.

Generation and Assessment of Soybean ( (L.) Merr.) Hybrids for High-Efficiency -Mediated Transformation.

The -mediated technique is widely employed for soybean transformation, but the efficiency of this method is still relatively modest, in which multiple factors are involved. Numerous chemical and physiological cues from host plants are needed for attraction and subsequent T-DNA integration into the plant genome. Susceptible genotypes may permit this attachment and integration, and the agronomically superior genotypes with susceptibility to would play an important role in increasing transformation efficiency.

Music Therapy as a Tool to Unveil Musical Potential or Hidden Savant in Children with Autism: A Case Study.

: Savant syndrome is a perplexing condition characterized by the exceptional abilities or talents of individuals with disabilities or low IQ. : This study shows an individual case of a child with autism, detailing how music therapy may facilitate the discovery of musical abilities and how it can improve different areas of development, e.g.

Alarming Signal from the Ear: Tinnitus, a Possible Epiphenomenon of Silent Hyperlipidaemia.

Over the past few decades, many studies have been conducted to explore the link between tinnitus and lipid metabolism, yielding inconsistent results. In our current study, we compared the prevalence of various lipid metabolism abnormalities in patients with chronic subjective idiopathic tinnitus (CSIT) to the official prevalence data of dyslipidaemia in the general adult Hungarian population. To counteract the distorting effect of the co-increase in both conditions with age, we also examined this relationship by age groups.

Modification of Erroneous and Correct Digital Texts.

The end-user paradox and the illusion of digital prosperity reveal the contradictory situation in which both non-professional and professional computer scientists and engineers seem satisfied with digital development but unaware of the magnitude of waste generated by end-users and their digital artifacts. To measure this waste and to reveal end-users' problem-solving strategies, our research group set up an objective measuring system that can calculate the entropy of digital texts (EDT). To calculate EDT, a testing process of 53 participants was launched where erroneous and correct natural language digital texts were modified according to the requirements of the tasks.

Efficacy of Prophylactic Antibiotics in COPD: A Systematic Review.

: Chronic obstructive pulmonary disease (COPD) is a global health problem and the third leading contributor to mortality worldwide. This systematic review aims to summarize the results of previous studies tackling the question of the efficacy of long-term prophylaxis of antibiotics in COPD patients, with particular regard to exacerbation rate, time to first exacerbation, health status, airway bacterial load, inflammatory markers, cell counts in sputum samples, and potential adverse events. : Four studies found significant improvement in the exacerbation rate in patients receiving antibiotic intervention.

Food Advertisement and Marketing Policies Aimed at Reducing Childhood Obesity: A Review of Existing Regulations in High-Income Countries.

Objectives: To identify and evaluate the difference between voluntary and mandatory food marketing policies and regulations targeting childhood obesity and to study the role of media, the food industry, and private associations in implementing such policies.

Methods: A review of policies and legislation about unhealthy food marketing was conducted by searching and extracting relevant grey literature from the websites of international health agencies, food marketing pledge databases, GINA, and NOURISHING policy databases. Statutory laws and self-regulations of high-income countries were compared with each other and with the WHO recommendations.

Synergistic effects of laser interstitial thermal therapy (LITT) and immunotherapy for brain tumor recurrence: A systematic review and meta-analysis.

Purpose: The confluence of laser interstitial thermal therapy (LITT) with immunotherapeutic approaches represents a promising option for managing recurrent brain lesions. However, the potential synergy between these modalities is still unclear. This meta-analysis examines the literature to elucidate the adverse effects and overall survival associated with this combination in treating recurrent brain metastases and glioblastoma.

Sleep deprivation and corneal chronobiology: reevaluating overnight corneal changes.

This prospective cohort study is aimed to investigate circadian variations in corneal parameters, focusing on sleep-deprived subjects. Sixty-four healthy individuals (age range: 21-76 years) actively participated in this study, undergoing examinations at least five times within a 24-hour timeframe. The analysis encompassed keratometric parameters of the cornea's front (F) and back (B) surfaces, refractive power in flattest and steepest axes (K1, K2), astigmatism (Astig) and its axis (Axis), aspheric coefficient (Asph), corneal pachymetry values of thinnest corneal thickness (Pachy Min) and corneal thickness in the center of the pupil (Pachy Pupil), volume relative to the 3 and 10 mm corneal diagonal (Vol D3, Vol D10) and surface variance index (ISV).

Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases.

Aging remains the foremost risk factor for cardiovascular and cerebrovascular diseases, surpassing traditional factors in epidemiological significance. This review elucidates the cellular and molecular mechanisms underlying vascular aging, with an emphasis on sex differences that influence disease progression and clinical outcomes in older adults. We discuss the convergence of aging processes at the macro- and microvascular levels and their contributions to the pathogenesis of vascular diseases.

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).

Breaking the guidelines: how financial unawareness fuels guideline deviations and inefficient DVT diagnostics.

Objectives: To examine factors impacting diagnostic evaluation of suspected deep vein thrombosis (DVT) by analyzing the test ordering patterns and provider decision-making within a universal health coverage system in Hungary.

Methods: We analyzed test orders for suspected DVT between 2007 and 2020, and the financial framework influencing diagnostic practices. An anonymous survey was also conducted among Emergency Department physicians to explore factors influencing diagnostic decision-making.