Developing new anticancer agents: Design, synthesis, biological evaluation and in silico study of several functionalized pyrimidine-5-carbonitriles as small molecules modulators targeting breast cancer.

Committed to our growing effort addressed toward the development of potent anti-breast cancer candidates, new 4-hydrazinylpyrimidine-5-carbonitriles featuring a morpholinyl or piperidinyl moiety at the position-2 and derivatized with various functionalities at the hydrazinyl group were designed through structure optimization, and their antiproliferative potency against two human breast cancer (BC) cell lines, relative to the reference drug 5-FU, was evaluated. Compounds showing remarkable cytotoxic activity versus the hormone dependent MCF-7 cell line (IC = 1.62 ± 0.

Design, synthesis and molecular docking study of new pyrimidine-based hydrazones with selective anti-proliferative activity against MCF-7 and MDA-MB-231 human breast cancer cell lines.

Efforts were directed on the design, synthesis and evaluation of the anticancer activity of some pyrimidine-based hydrazones against two breast cancer cell lines, MCF-7 and MDA-MB-231. Preliminary screening results revealed that some candidates scrutinized for their antiproliferative activities exhibited IC values of 0.87 μM-12.

Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer.

Novel series of benzoxazole-appended piperidine derivatives were planned, synthesized and screened against two breast cancer cell lines. Considerable antiproliferative activity was observed for screened compounds (IC = 33.32 ± 0.

Design and Synthesis of Novel Quinazolinone-Based Oxobutanenitrile Derivatives as Antiproliferative Agents Targeting Human Breast Cancer.

Background: Breast cancer (BC) is among the leading causes of death in women worldwide. Medical interest has focused on quinazolinone derivatives approved and utilized in antitumor medications.

Objective: Novel quinazolinone-based oxobutanenitrile derivatives were designed, synthesized, and screened for in vitro anti-breast cancer activity.

2-Anilinopyrimidine derivatives: Design, synthesis, in vitro anti-proliferative activity, EGFR and ARO inhibitory activity, cell cycle analysis and molecular docking study.

Novel anti-proliferative agents possessing pyrimidine scaffolds were designed, synthesized and evaluated for their IC values using MTT assay. Most compounds displayed good to excellent activity against the two tested breast cancer lines (MCF-7 and MDA-MB-231) as compared to 5-FU. The observed IC values for active compounds ranged from 0.

Corrigendum to "Effect of lower leg compression during cesarean section on post-spinal hypotension and neonatal hemodynamic parameters: Nonrandomized controlled clinical trial" [Int J Nurs Sci 6/3 (2019) 252-258].

[This corrects the article DOI: 10.1016/j.ijnss.

Effect of lower leg compression during cesarean section on post-spinal hypotension and neonatal hemodynamic parameters: nonrandomized controlled clinical trial.

Objectives: This study aimed to determine the effect of lower leg compression during cesarean section (CS) on post-spinal hypotension (PSH) and neonatal hemodynamic parameters.

Methods: This study is a nonrandomized controlled clinical trial conducted in the cesarean delivery unit of the National Medical institute, Damanhour, Egypt. The sample included 120 parturients (60 intervention and 60 control).

Synthesis of carbon nano-onion embedded metal-organic frameworks as an efficient adsorbent for cadmium ions: kinetic and thermodynamic studies.

Carbon nano-onions (CNOs), metal-organic frameworks (MOF-199), and carbon nano-onion embedded metal-organic frameworks (CMOF-199) were synthesized from garlic peels as a green source of carbon atoms while MOF-199 was prepared by solvothermal interaction between 1,3,5-benzenetricarboxylic acid and copper nitrate trihydrate. All the prepared solid materials were characterized by nitrogen adsorption/desorption isotherm, transmission electron microscopy (TEM), energy-dispersive X-ray (EDX), X-ray diffraction (XRD), thermogravimetric analysis (TGA), point of zero charge (pH), and Fourier transform infrared spectroscopy (FTIR). Adsorption of cadmium ions from aqueous solution was investigated onto all prepared solid materials considering different application conditions such as adsorbent dosage, pH, contact time, initial concentration of Cd, and temperature.

Chitosan/nanohydroxyapatite composite based scallop shells as an efficient adsorbent for mercuric ions: Static and dynamic adsorption studies.

Chitosan/nanohydroxyapatite composites based on scallop shells (CP12, CP14 and CP21) were prepared with different chitosan: nanohydroxyapatite ratios (1:2, 1:4 and 2:1, respectively). Nanohydroxyapatite (P), chitosan(C) and their composites were characterized by means of TGA, XRD, N adsorption/desorption analysis, SEM, Zeta potential and FTIR. The BET surface area ranged between 189 and 512 m/g.

Thermomechanical Fractional Model of TEMHD Rotational Flow.

In this work, the fractional mathematical model of an unsteady rotational flow of Xanthan gum (XG) between two cylinders in the presence of a transverse magnetic field has been studied. This model consists of two fractional parameters α and β representing thermomechanical effects. The Laplace transform is used to obtain the numerical solutions.

Simultaneous spectrophotometric determination of the three structural isomers of cresol using multivariate regression methods.

The simultaneous determination of the structural isomers of cresol was carried out using UV spectrophotometry by applying the principle component regression (PCR) and partial least squares (PLS) regression methods. Different concentration levels of cresol isomers were determined in their mixtures by construction of a partial factorial calibration design at four levels. Both multivariate calibration models were constructed using the correlation between the concentration and absorbance data matrices in the spectral region 283-305 nm.

Enantioselective HPLC-DAD method for the determination of etodolac enantiomers in tablets, human plasma and application to comparative pharmacokinetic study of both enantiomers after a single oral dose to twelve healthy volunteers.

An enantioselective high performance liquid chromatographic method with diode array detection (HPLC-DAD) was developed and validated for the determination of etodolac enantiomers in tablets and human plasma. Enantiomeric separation was achieved on a Kromasil Cellucoat chiral column (250 mm × 4.6mm i.