Core-size and geometry toxicity in small amino terminated PAMAM dendrimers.

A series of 6 small PAMAM dendrimers (G0-dendrimers) differing in the size, polarity and flexibility has been synthesized. The toxicity has been investigated in three different human cancer cell lines (HeLa, MCF-7, THP-1) and the endothelial skin cell line HMEC-1 in order to evaluate their potential as vehicles for drug delivery.

A new donor for charge-transfer systems: synthesis and properties of 2,4,7,9-tetramethyl-1,6-dithiapyrene (TMDTP) and structure of (TMDTP)(PF)·2THF and TMDTP-TCNQ.

The heterocyclic donor molecule 2,4,7,9-tetramethyl-1,6-dithiapyrene (TMDTP) has been synthesized in five steps. Oxidation of TMDTP is facile ( = 0.27 V and = 0.