19,102 results match your criteria: "University of Colorado Anschutz Medical Campus;Dermatology Service[Affiliation]"
BMJ
January 2025
Biostatistics Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups of individuals (known as clusters) to different sequences of interventions over time. The design has gained popularity in settings where cluster randomisation is required because it can largely overcome the loss in power due to clustering in parallel cluster trials.
View Article and Find Full Text PDFJ Lipid Res
January 2025
Department of Medicine, University of Washington, Seattle, WA 98109.
Background: Atherosclerotic cardiovascular disease (CVD) is a major cause of death in individuals with type 1 diabetes mellitus (T1DM). However, conventional risk factors do not fully account for the increased risk. This study aimed to investigate whether serum proteins associate with diabetes status and the occurrence of CVD in T1DM.
View Article and Find Full Text PDFBlood
January 2025
Brigham and Women's Hospital, Boston, Massachusetts, United States.
Clin Cancer Res
January 2025
University of Nebraska Medical Center, OMAHA, NE, United States.
Purpose: Breast cancer (BC) brain metastasis (BrM) remains a significant clinical problem. Mucins have been implicated in metastasis; however, if they are also involved in BCBrM remains unknown. We queried BrM patient databases and found Mucin 5AC (MUC5AC) to be upregulated and therefore sought to define the role of MUC5AC in BCBrM.
View Article and Find Full Text PDFGut Microbes
December 2025
Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. However, the microbiome's role in metabolite production and the influence of gut dysbiosis on this process remain unclear. Further, studies on the relationship among gut microbes, metabolites, and biological activities of phytochemicals are limited.
View Article and Find Full Text PDFAm J Gastroenterol
January 2025
University of Chicago Medicine, Inflammatory Bowel Disease Center.
Environ Res Health
October 2024
Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
As temperatures defy heat records, it is difficult to ignore the implications of climate change for public health, including impacts on population health more specifically. In short, climate change is happening now and presents an immediate hazard to human health on a global scale. Age-related health effects are an inalienable truth; physiology is relatively universal, and so are the ways in which our bodies respond to different types and levels of exposures to environmental stressors at different lifestages.
View Article and Find Full Text PDFJACC Adv
January 2025
Department of Surgery, Division of Transplant Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Background: Currently, there is no mathematical model used nationally to determine the medical urgency of patients on the heart transplant waitlist in the United States. While the current organ distribution system accounts for many patient factors, a truly objective model is needed to more reliably stratify patients by their medical acuity.
Objectives: The aim of the study was to develop risk scores (Colorado Heart failure Acuity Risk Model [CHARM] score) to predict mortality in adults waitlisted for heart transplant.
Addict Behav Rep
June 2025
Institute of Behavioral Science, University of Colorado Boulder, 1440 15th St., Boulder, CO 80309, USA.
This study examines whether adolescent nicotine and cannabis vaping types (i.e., nicotine-only, cannabis-only, and dual use) differ across sociodemographic and school characteristics (e.
View Article and Find Full Text PDFFront Psychiatry
December 2024
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States.
Opioid Use Disorder (OUD) is an ongoing worldwide public health concern. Genetic factors contribute to multiple OUD-related phenotypes, such as opioid-induced analgesia, initiation of opioid use, and opioid dependence. Here, we present findings from a behavioral phenotyping protocol using male and female rats from 15 genetically diverse inbred strains from the Hybrid Rat Diversity Panel (HRDP).
View Article and Find Full Text PDFExpert Opin Drug Metab Toxicol
January 2025
Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Inflamm Bowel Dis
January 2025
Division of Gastroenterology, University of California San Diego, La Jolla, CA, USA.
Background: Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays a critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability of its mRNA transcript, determined in part by destabilizing sequences in its AAUU repeats (ARE) gene region, is an important regulator of its tissue and systemic levels. A deletion in the ARE region of the gene resulted in IBD and arthritis in mice and pigs, supporting a critical role for the cytokine in human IBD and several human arthritides.
View Article and Find Full Text PDFAm J Epidemiol
January 2025
Department of Public Health Leadership and Practice, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Exposure to the United States criminal legal system - whether through contact with law enforcement, incarceration in a jail or prison, or community supervision - is associated with a range of adverse health outcomes. There is mounting evidence that mass incarceration drives health inequities, particularly for Black, Indigenous, and People of Color. However, relative to its outsized impacts on health and health inequities, the criminal legal system has received limited attention in epidemiology.
View Article and Find Full Text PDFSTAR Protoc
January 2025
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:
Here, we present a protocol to alter the production of alternatively spliced mRNA variants, without affecting the overall gene expression, through CRISPR-Cas9-engineered genomic mutations in mice. We describe steps for designing guide RNA to direct Cas9 endonuclease to consensus splice sites, producing transgenic mice through pronuclear injection, and screening for desired mutations in cultured mammalian cells using a minigene splicing reporter. Splice isoform-specific mouse mutants provide valuable tools for genetic analyses beyond loss-of-function and transgenic alleles.
View Article and Find Full Text PDFNeuromolecular Med
January 2025
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 2014, unites a worldwide community dedicated to understanding the impact of T21 on biological systems and improving the quality of life of people with DS across the lifespan. T21RS hosts an international conference every two years to support collaboration, dissemination, and information sharing for this goal.
View Article and Find Full Text PDFJ Cyst Fibros
January 2025
Cystic Fibrosis Therapeutics Development Network Coordinating Center, Seattle Children's Hospital, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Background: Highly effective CFTR modulators improve CFTR function and lead to dramatic improvements in health outcomes in many people with cystic fibrosis (pwCF). The relationship between measures of CFTR function, such as sweat chloride concentration, and clinical outcomes in pwCF treated with CFTR modulators is poorly defined. We conducted analyses to better understand the relationships between sweat chloride and CFTR function in vitro, and between sweat chloride and clinical outcomes following CFTR modulator treatment.
View Article and Find Full Text PDFDev Biol
January 2025
Department of Molecular, Cellular and Development Biology, University of Colorado, Boulder, CO, 80309, USA. Electronic address:
Folic acid (FA) supplementation is a potent tool to reduce devastating birth defects known as neural tube defects (NTDs). Though effective, questions remain how FA achieves its protective effect and which gene mutations are sensitive to folic acid levels. We explore the relationship between FA dosage and NTD rates using NTD mouse models.
View Article and Find Full Text PDFPaediatr Anaesth
January 2025
Department of Anesthesiology, Duke University School of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Background: In pediatric patients, the use of processed EEG monitoring may reduce the amount of anesthesia administered while maintaining adequate depth of anesthesia.
Aims: The primary aim of this study was to evaluate whether use of a BIS monitor to guide sevoflurane administration might reduce the average end tidal sevoflurane concentration used in children 4-18 years of age.
Methods: Participants in three age groups (4-8, 9-12, and 13-18 years) were randomized to either the BIS guided group or the control group.
Scand J Trauma Resusc Emerg Med
January 2025
International Commission for Mountain Emergency Medicine (ICAR MedCom), Zürich, Switzerland.
J Gen Intern Med
January 2025
Department of General Internal Medicine, University of Colorado, Anschutz Campus, Aurora, CO, USA.
NPJ Precis Oncol
January 2025
Athinoula A. Martinos Center for Biomedical Imaging, 149 13th St, Charlestown, MA, 02129, USA.
J Cardiothorac Vasc Anesth
December 2024
Department of Cardiothoracic Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO.
J Neurosurg Pediatr
January 2025
4Department of Neurosurgery, Children's Hospital Colorado Anschutz Medical Campus, Aurora; and.