Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers.

The urgent need for new antimicrobial compounds has led scientists to explore antimicrobial peptides (AMPs) and antimicrobial polymers as solutions for multidrug resistance. In this study, we synthesized copolymers with cationic and hydrophobic moieties by free-radical polymerization (FRP) using a chain transfer agent to control molecular weights. The potential of natural products as part of the hydrophobic moiety was evaluated, along with variations in their monomer content (13-25%) and the molecular weight (MW) of the copolymer (5000-20,000 g·mol).

Age-associated metabolic and epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes.

Heart disease is the leading cause of mortality in developed countries, and novel regenerative procedures are warranted. Direct cardiac conversion (DCC) of adult fibroblasts can create induced cardiomyocytes (iCMs) for gene and cell-based heart therapy, and in addition to holding great promise, still lacks effectiveness as metabolic and age-associated barriers remain elusive. Here, by employing MGT (Mef2c, Gata4, Tbx5) transduction of mouse embryonic fibroblasts (MEFs) and adult (dermal and cardiac) fibroblasts from animals of different ages, we provide evidence that the direct reprogramming of fibroblasts into iCMs decreases with age.

Primary manipulation knowledge of objects is associated with the functional coupling of pMTG and aIPS.

Correctly using hand-held tools and manipulable objects typically relies not only on sensory and motor-related processes, but also centrally on conceptual knowledge about how objects are typically used (e.g. grasping the handle of a kitchen knife rather than the blade avoids injury).

Perceived discrepancies in neurosonology training and certification across Europe: a RRFS/EAN survey.

Introduction: Neurosonology is a vital paraclinical investigation in modern neurology. However, access to education and certification in neurosonology for neurology residents and young specialists in Europe is challenging, and comprehensive data regarding this topic are scarce. Information regarding difficulties in neurosonology training across Europe may help bring this topic under the spotlight and act as a call for the harmonization of curricula across the continent.

Inside-out tibial tunnel drilling technique is a reliable approach for all-inside ACL reconstruction: A longitudinal MRI assessment.

Purpose: To longitudinally evaluate sockets localization, tunnel morphological changes and graft maturation after the . We hypothesized that due the necessary angle for the inside-out reaming procedure, the described technique could input changes in the tibial socket.

Methods: Fourteen knees treated with the same all-inside ACLR technique were randomly assigned for a magnetic resonance evaluation.

Managing Urticarial Vasculitis: A Clinical Decision-Making Algorithm Based on Expert Consensus.

Urticarial vasculitis (UV) is a rare and difficult-to-treat, small-vessel leukocytoclastic vasculitis presenting with recurrent long-lasting wheals. So far, no guidelines and treatment algorithms exist that could help clinicians with the management of UV. In this review, we describe evidence on systemic treatments used for UV and propose a clinical decision-making algorithm for UV management based on the Urticarial Vasculitis Activity Score assessed for 7 days (UVAS7).

Investigation of variable range hopping and dielectric relaxation in GdCrO orthochromite perovskites.

This study investigates the structural, electrical, and dielectric properties of GdCrO (GCO) compounds. X-ray diffraction analysis confirmed the formation of the perovskite phase of GCO, crystallizing with the space group. Scanning electron microscopy (SEM) was employed to examine the morphology and chemical composition of the powder, ensuring compound homogeneity, while transmission electron microscopy (TEM) provided insights into the internal structure and finer morphology of the GCO sample.

Lapachol, a natural food component, interacts with human serum albumin: Insights of its impact on the pharmacokinetics of clinically used drugs.

Lapachol (LAP), a natural 1,4-naphthoquinone used in popular medicine in South America, is an antioxidant and antimicrobial compound in teas and infusions and used as a food additive; however, its interactive profile with the main protein carrier of compounds in the human bloodstream (human serum albumin, HSA) was not still characterized. Additionally, the impact of LAP in binding clinically drugs to albumin is still unknown. Thus, the present work describes the interaction HSA:LAP using different biophysical techniques, i.

Basal Ganglia's influence on awake test in carotid endarterectomy.

Background: White matter changes (WMC) have been associated with the underlying presence of chronic cerebral ischemia, such as in carotid stenosis and age-related white matter changes (ARWMC). A low attenuation on computed tomography (CT) characterizes these alterations. Patients undergoing carotid endarterectomy (CEA) with severe WMC may be at increased risk of intraoperative neurologic deficits (IND) during carotid clamping.

Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan.

The therapeutic interest of renin-angiotensin system (RAS) drugs for the treatment of neuroinflammation has been recently acknowledged. Nevertheless, most of them display limited passage across the blood-brain barrier (BBB). Therefore, this study investigated the potential of intranasal (IN) delivery of six RAS drugs to circumvent the BBB and attain the brain, envisioning its future use in central nervous system (CNS) neuroinflammatory diseases, such as Alzheimer's disease (AD).

Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia.

Background And Objectives: Sleep dysfunction is common in patients with neurodegenerative disorders; however, its neural underpinnings remain poorly characterized in genetic frontotemporal dementia (FTD). Hypothalamic nuclei important for sleep regulation may be related to this dysfunction. Thus, we examined changes in hypothalamic structure across the lifespan in patients with genetic FTD and whether these changes related to sleep dysfunction.

Association of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With Frontotemporal Dementia.

Background And Objectives: Pathogenic variants in the gene cause frontotemporal dementia (FTD-) with marked brain asymmetry. This study aims to assess whether the disease progression of FTD- depends on the initial side of the atrophy. We also investigated the potential use of brain asymmetry as a biomarker of the disease.

Clinical and Histopathologic Findings in Jalili Syndrome.

Purpose: To correlate histopathologic findings in an eye with Jalili syndrome with clinical and imaging results available before enucleation.

Design: Case report with histopathologic analysis.

Subjects: Histopathologic analysis of an enucleated eye from a 63-year-old woman diagnosed with Jalili syndrome.

Perceived Causes of Sleep Problems in Higher Education Students: An Exploratory Study.

The major purpose of the present study was to explore higher education students' perceptions of the causes of their sleep problems. The data were drawn from a previous cross-sectional online survey, from which only the questions relevant to this study were selected, including items on sleep disturbances and their causes. The participants included 1519 full-time students (76% women), aged 18-30 years ( = 20.

Monocyte Count as a Predictor of Major Adverse Limb Events in Aortoiliac Revascularization.

Atherosclerosis is a leading cause of death, especially in the developed world, and is marked by chronic arterial inflammation and lipid accumulation. As key players in its progression, monocytes contribute to plaque formation, inflammation, and tissue repair. Understanding monocyte involvement is crucial for developing better therapeutic approaches.

Electrospun Nanofiber Dopped with TiO and Carbon Quantum Dots for the Photocatalytic Degradation of Antibiotics.

Novel photocatalysts were synthesized through the association of carbon quantum dots (CQDs) with commercial (P25) titanium dioxide (TiO) by sonication. The resulting TiO/CQDs composite was then incorporated into the polyamide 66 (PA66) biopolymer nanofibers using the electrospinning technique, considering a composite nanoparticles-to-polymer ratio of 1:2 in the electrospinning precursor solution. The produced nanofibers presented suitable morphology and were tested for the photocatalytic degradation under simulated solar radiation of 10 mg L of amoxicillin (AMX) and sulfadiazine (SDZ), in phosphate buffer solution (pH 8.

Medication Management in Portuguese Long-Term Care Facilities: A Preliminary Cross-Sectional Study.

Background/objectives: Population ageing has been a pressing global issue for decades. Older adults, especially those residing in long-term care facilities (LTCFs), often experience frailty and polypharmacy, which can lead to negative clinical outcomes. In Portugal, LTCFs provide essential care for individuals aged 65 or older, offering temporary or permanent accommodation.

Study Protocol for the Development and Preliminary Efficacy Assessment of : A Web-Based Mindful Parenting Postadoption Intervention.

Developing postadoption interventions to prevent parenting stress and promote parents' well-being is urgent. Mindful parenting-based interventions show promise in achieving these goals and are well received by adoptive parents (APs). However, face-to-face interventions face significant barriers.

A scoping review on implementation processes and outcomes of models of care for low back pain in primary healthcare.

Background: To address the societal burden of low back pain (LBP), several health systems have adopted Models of Care (MoCs). These evidence-informed models aim for consistent care and outcomes. However, real-world applications vary, with each setting presenting unique challenges and nuances in the primary healthcare landscape.