Examining sex differences in morningness-eveningness and inter-individual variability across years of age: A cross-sectional study.

This study investigated the impact of age on morningness-eveningness (ME) and its inter-individual variability, with a focus on sex-specific patterns. A sample of 2890 participants aged 12-94 years (55.85% female) completed the Composite Scale of Morningness.

Quality of vision with monofocal intraocular lens after cataract surgery: Comprehensive evaluation and graphical illustration.

Purpose: To comprehensively characterize the quality of vision (QV) in an otherwise healthy population undergoing bilateral consecutive cataract surgery with the implantation of a monofocal intraocular lens (IOL) and to propose a graphical illustration.

Setting: , Portugal.

Design: Cross-sectional study.

Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation.

Neuroinflammation is an undoubted hallmark of neurodegenerative processes characterized by memory impairment, loss of coordination and muscle strength in diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis as well as depressive disorders. Cyclosporine A (CSA) has already been identified as a promising neuroprotective peptide, due to its well-known anti-inflammatory properties. Herein, CSA was encapsulated into α-tocopherol polyethylene glycol 1000 succinate (TPGS) micelles and intranasally administered to a lipopolysaccharide (LPS) induced mouse model of neuroinflammation.

Fresh osteochondral allograft transplantation of the medial femoral condyle in an elite football player.

We present an elite footballer in his 20s with a large and symptomatic osteochondral lesion of the weight-bearing area of the medial femoral condyle, who was proposed for a single plug fresh osteochondral allograft transplantation. The lesion was due to repetitive micro traumas and had become highly symptomatic being responsible for making the football practice at a professional level almost impossible, reaching a point that keeping an elite sports career was compromised. Six months after surgery, the athlete returned to sports and, at a 3-year follow-up, still participated in elite high-level football, with a Tegner Activity Scale 10/10, IKDC 93.

Effects of wildfire ash on the fatty acid and sugar profiles of bivalves - a comparative study of a freshwater and a marine species.

Wildfires can impact both freshwater and marine ecosystems through post-fire runoff, but its effects on bivalves, particularly those living in marine habitats, remain largely overlooked. While evidence exists that wildfire ash can alter the fatty acid (FA) and sugar profiles of aquatic biota, its influence on the biochemical profiles of bivalves have not been addressed to date. This study aimed to assess the effects of ash exposure on the FA and sugar profiles of two bivalve species used for human consumption: a freshwater clam (Corbicula fluminea) and a marine bivalve (Cerastoderma edule), additionally evaluating potential effects on their nutritional value.

Reassessing cardiovascular risk stratification in men with erectile dysfunction.

Background And Objectives: Erectile dysfunction (ED) is an independent and strong marker of cardiovascular disease (CVD) risk. The Princeton Consensus aimed to evaluate and manage cardiovascular risk in men with ED and no known cardiovascular disease, focusing on identifying those requiring additional cardiologic work-up. It has recently been updated to the American population demographics, but European recommendations are needed.

The evolving treatment landscape of multiple myeloma in Portugal: A nation-wide retrospective cohort study of real-world clinical practice.

Objectives: To characterize variations in real-world treatment patterns in multiple myeloma (MM) in Portugal over a 5-year period.

Methods: A retrospective cohort multicenter study using secondary data of national hospital drug consumption database from 11 Portuguese public hospitals between 2017 and 2022.

Results: Number of MM-treated patients increased 53% over 5 years (from 825 to 1266 patients).

The genetic origins and impacts of historical Papuan migrations into Wallacea.

The tropical archipelago of Wallacea was first settled by anatomically modern humans (AMH) by 50 thousand years ago (kya), with descendent populations thought to have remained genetically isolated prior to the arrival of Austronesian seafarers around 3.5 kya. Modern Wallaceans exhibit a longitudinal countergradient of Papuan- and Asian-related ancestries widely considered as evidence for mixing between local populations and Austronesian seafarers, though converging multidisciplinary evidence suggests that the Papuan-related component instead comes primarily from back-migrations from New Guinea.

Influence of different cavity disinfectants on composite adhesion to dentin of primary teeth: An study.

Restorative treatment is the most common approach to treating dental caries. However, after cavity preparation, some microorganisms may still persist in the substrate, suggesting the use of cavity disinfectants. Nevertheless, their effect on adhesion to composite resins is not yet fully understood, especially in primary teeth.

Differences in lean mass and sarcopenia between individuals with Alzheimer's disease and those without dementia: A systematic review and meta-analysis of observational studies.

Background: Studies have observed that individuals with Alzheimer's disease (AD) tend to have lower lean mass and higher rates of sarcopenia.

Objective: This review aims to assess differences in lean mass, sarcopenia, and its components between individuals with AD and those without dementia (WD).

Methods: Searches were conducted in the Medline, Web of Science, Embase, Scopus and Latin American and Caribbean Health Scientific Literature.

Ultrasound Versus Elastography in the Diagnosis of Hepatic Steatosis: Evaluation of Traditional Machine Learning Versus Deep Learning.

The prevalence of fatty liver disease is on the rise, posing a significant global health concern. If left untreated, it can progress into more serious liver diseases. Therefore, accurately diagnosing the condition at an early stage is essential for more effective intervention and management.

Health-Related Quality of Life with Iatrogenic Inferior Alveolar Nerve Injuries Treated with Photobiomodulation: A Comparative Study.

: Photobiomodulation therapy (PBM) creates a biostimulatory or modulatory effect, promoting tissue regeneration and improving patients' health-related quality of life (HRQoL). PBM has shown promise as an effective treatment and management strategy for peripheral nerve injuries, including inferior alveolar nerve (IAN) damage. This study aims to assess the impact of PBM on HRQoL in patients with iatrogenic IAN injuries.

Influence of the Ag Content on the Natural and Thermal Induced Oxidation of Cu Thin Films.

In this paper, we studied the deposition and characterization of monolithic and silver-doped copper coatings using RF magnetron sputtering. The main objective was to examine the impact of different Ag contents on natural and thermally induced aging when compared with monolithic copper coatings. For this purpose, the as-deposited surfaces were left exposed to normal temperature and humidity conditions during one year (natural) and were annealed at 200 °C in a non-controlled atmosphere.

Green Synthesis of CuO Nanoparticles-Structural, Morphological, and Dielectric Characterization.

This study investigates the structural, chemical, and morphological properties of CuO nanoparticles synthesized via a green synthesis route using - cladode extract, with a focus on the effects of stepwise versus direct calcination. Raman spectroscopy revealed the presence of CuO, NaCO, and NaSO, with the latter two being associated with elements inherited from the cactus extracts. XRD patterns confirmed the presence of crystalline CuO and NaCO phases, with the low content of NaSO inferred to be amorphous.

A Starting Point on Recycling Land and Sea Snail Shell Wastes to Manufacture Quicklime, Milk of Lime, and Hydrated Lime.

The valorization of gastropod shell wastes in the production of lime is the topic of this study. First, shells from land snail and sea snail were characterized for their mineralogical, chemical, and thermal properties. Then, the shells were calcined at 1000 °C, and the obtained quicklimes were characterized for their specific surface area, pore diameter, and particle morphology, followed by evaluation of their reactivity in wet slaking tests.

Lignin-Furanic Rigid Foams: Enhanced Methylene Blue Removal Capacity, Recyclability, and Flame Retardancy.

Worldwide, populations face issues related to water and energy consumption. Water scarcity has intensified globally, particularly in arid and semiarid regions. Projections indicate that by 2030, global water demand will rise by 50%, leading to critical shortages, further intensified by the impacts of climate change.

Virus Removal from Real Wastewater as an Environmental Management Approach.

The increased presence of resistant microorganisms in water promotes the need for supplementary measures to mitigate the water source's contamination. Traditional treatments are inefficient in wastewater management at removing some emerging contaminants. an invasive species, can be used in the treatment due to their resistance and biofiltration capacity, working as a pest management strategy.

Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics.

Manganese-based MRI contrast agents have recently attracted much attention as an alternative to Gd-based compounds. Various nanostructures have been proposed for potential applications in in vivo diagnostics and theranostics. This review is focused on the discussion of different types of Mn oxide-based nanoparticles (MnO NPs) obtained at the +2, +3 and +4 oxidation states for MRI, multimodal imaging or theranostic applications.

From Olive Oil Lovers to Mediterranean Diet Lifestyle Followers: Consumption Pattern Segmentation in the Portuguese Context.

The Mediterranean Diet (MedDiet) is considered an Intangible Cultural Heritage by UNESCO; it is also the world's most evidence-based eating pattern for promoting health and longevity. This study aims to investigate consumer segmentation based on consumption patterns and identify barriers to adherence to MedDiet. Data were collected in 2020 by telephonic survey based on PREDIMED, using a quota sampling technique by socio-demographic variables, such as gender, age, and regional representation of the Portuguese population.

Nutritional Genomics: Implications for Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a leading cause of vision loss in older individuals, driven by a multifactorial etiology involving genetic, environmental, and dietary factors. Nutritional genomics, which studies gene-nutrient interactions, has emerged as a promising field for AMD prevention and management. Genetic predispositions, such as variants in , , , , and oxidative stress pathways, significantly affect the risk and progression of AMD.

Sugar Content in L. Fruit and Its Relationship with Climatic and Edaphic Characteristics.

This research was carried out as part of a program for the conservation and improvement of the strawberry tree. Accessions' prospecting was conducted in different Portuguese provenances. Accessions (204) were identified, and mature fruits were collected in autumn.

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis.

This review delves into the significant cellular and molecular responses triggered by UVR exposure in human skin, emphasizing the pivotal role of mutant p53 (mutp53) in the carcinogenic process elicited by radiation. By underlining the role of a functional p53 in safeguarding skin cells from UVR-induced damage, this work underscores the potential significance of targeting mutp53, aiming to restore its wild-type-like activity (reactivation), as a protective strategy against skin cancer (SC), particularly NMSC. Most importantly, an interesting crosstalk between p53 and its vitamin D receptor (VDR) transcriptional target is also highlighted in the suppression of skin carcinogenesis, which opens the way to promising chemopreventive strategies involving synergistic combinations between mutp53 reactivators and vitamin D.

Ferroptosis driven by nanoparticles for tackling glioblastoma.

Glioblastoma (GBM) is the most aggressive, malignant, and drug-resistant brain tumor. There are no effective treatment options for GBM, which usually leads to relapses that cause patients to die a few months later. Ferroptosis, a newly discovered mechanism of regulated cell death, has been identified as a tumor suppressor in solid tumors and represents an alternative to apoptosis resistance.

Did social isolation affect anxiety and sleep quality of elite soccer players during the COVID-19 lockdown? Comparisons to training before distancing in the pandemic and outlook for mental health.

Objective: To analyze the anxiety levels and sleep quality of elite soccer athletes in training pre-pandemic and during the lockdown caused by COVID-19.

Method: This is an exploratory study with a longitudinal design carried out with elite soccer athletes from two Brazilian soccer clubs. Data collection took place in person pre-pandemic (training) and online (during lockdown) between February and May 2020.