56 results match your criteria: "University of Cincinnati College of Medicine Cincinnati OH.[Affiliation]"
Background There is concern that selective serotonin reuptake inhibitors ( SSRI s) substantially increase bleeding risk in patients taking anticoagulants. Methods and Results We studied 737 patients taking SSRI s in the ROCKET AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Embolism and Stroke Trial in Atrial Fibrillation) trial of rivaroxaban compared with warfarin for the prevention of stroke/systemic embolism in patients with atrial fibrillation. These patients were propensity score matched 1:1 to 737 patients not taking SSRI s.
View Article and Find Full Text PDFArticle Synopsis
- Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver issues from mild fat accumulation to serious conditions like cirrhosis and cancer, with inflammation and oxidative stress playing key roles in its progression.
- Elevated reactive oxygen species (ROS) production, particularly from immune cells, is linked to NAFLD, and the NOX2 enzyme has been identified as a significant contributor to this process, affecting both inflammation and metabolism during obesity.
- Research showed that eliminating NOX2 in mice reduced ROS levels, lessened liver inflammation and damage, and indicated that targeting NOX2 could be a potential strategy for treating obesity-related NAFLD.
A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT).
Am J Kidney Dis
July 2018
Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Background: Poor adherence to immunosuppressive medications is a major cause of premature graft loss among children and young adults. Multicomponent interventions have shown promise but have not been fully evaluated.
Study Design: Unblinded parallel-arm randomized trial to assess the efficacy of a clinic-based adherence-promoting intervention.
Hepatitis C virus infection in children and adolescents.
Hepatol Commun
April 2017
Division of Gastroenterology Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati OH.
Among persons living with human immunodeficiency virus (HIV) infection, liver disease remains a major cause of morbidity and mortality. While the etiologies are varied and often overlapping in the individual patient, the underlying mechanisms, including oxidative stress, direct activation of stellate cells, HIV interaction with hepatocytes, and bacterial translocation with systemic immune activation, seem to be unifying characteristics. Early and fully suppressive HIV antiretroviral therapy is a mainstay of management either before or concurrent with treatment of etiologic cofactors, including hepatitis C virus, hepatitis B virus, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
View Article and Find Full Text PDFNovel approaches to the treatment of biliary atresia.
Clin Liver Dis (Hoboken)
December 2016
Liver Care Center and Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center; and Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH.