Documenting adaptations to an evidence-based intervention in 58 resource-variable pediatric oncology hospitals across implementation phases.

Background: Adaptation of evidence-based interventions (EBIs) often occurs when implemented in new local contexts and settings. It is unclear, however, during which phase of implementation adaptations are most frequently made and how these changes may impact the fidelity, effectiveness, and sustainability of the EBI. Pediatric Early Warning Systems (PEWS) are EBIs for early identification of deterioration in hospitalized children with cancer.

The UPRising connection between endoplasmic reticulum stress and the tumor microenvironment.

The tumor microenvironment (TME) represents a dynamic network of cancer cells, stromal cells, immune mediators, and extracellular matrix components, crucial for cancer progression. Stress conditions such as oncogene activation, nutrient deprivation, and hypoxia disrupt the endoplasmic reticulum (ER), activating the unfolded protein response (UPR), the main adaptive mechanism to restore ER function. The UPR regulates cancer progression by engaging cell-autonomous and cell-non-autonomous mechanisms, reprogramming the stroma and promoting immune evasion, angiogenesis, and invasion.

CsCO-Catalyzed Rauhut-Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[]oxepin Derivatives.

The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut-Currier-type reaction catalyzed by CsCO to access these important compounds. The developed methodology avoids the use of phosphine- or amine-based catalysts and additives.

Morphine self-administration is inhibited by the antioxidant N-acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration.

Background: The treatment of opioid addiction mainly involves the medical administration of methadone or other opioids, aimed at gradually reducing dependence and, consequently, the need for illicit opioid procurement. Thus, initiating opioid maintenance therapy with a lower level of dependence would be advantageous. There is compelling evidence indicating that opioids induce brain oxidative stress and associated glial activation, resulting in the dysregulation of glutamatergic homeostasis, which perpetuates drug intake.

Facial and dental arch shape in individuals with different bite force levels : A pilot study using geometric morphometrics.

Purpose: This pilot study aimed to assess the relationship between bite force variation and dental arch and facial shape using geometric morphometrics, an advanced method of statistical analysis that provides a detailed shape analysis of a structure considering the spatial relationship of its parts.

Methods: The sample consisted of 16 German adult men and women. For each individual, maximum bite force was recorded in four positions: maximum intercuspation, protrusion, laterotrusion to the right and to the left.

Effective Acoustic Model-Based Beamforming Training for Static and Dynamic Hri Applications.

Human-robot collaboration will play an important role in the fourth industrial revolution in applications related to hostile environments, mining, industry, forestry, education, natural disaster and defense. Effective collaboration requires robots to understand human intentions and tasks, which involves advanced user profiling. Voice-based communication, rich in complex information, is key to this.

The Role of Viruses in Pulpal and Apical Disease: A Systematic Review.

Apical lesions are diseases of infectious origin that can cause destruction of the surrounding periapical tissue, including bone tissue and periodontal ligaments, resulting in the loss of the affected teeth. Currently, the microorganisms present in pulp and apical disease are mostly studied as bacteria. However, in recent years, interest has been aroused in the study of viruses that could be present in apical lesions, and how these could affect the progression of disease.

Global Comparison of COVID-19 Vaccination Rates among Psoriasis Patients.

(1) Background: The purpose of this study is to compare the rate of COVID-19 vaccination among psoriasis patients internationally and to correlate it with their treatment regimens. (2) Methods: We conducted a cross-sectional study from January 2021 to October 2022 among adults in the United States (US), Chile, China, Switzerland, and Singapore using the Global Healthcare Study on Psoriasis survey. (3) Results: A total of 310 psoriasis patients in the US (98), Chile (32), China (80), Switzerland (39), and Singapore (61) were surveyed.

Leucine Intake and Sarcopenia Indicators of an Elderly Group from the Metropolitan Region, Santiago de Chile, Who Participated in the Program for Complementary Food in Older People (PACAM).

Background And Objective: The global aging population has led to increased noncommunicable diseases, often linked to poor diet and declining muscle strength and mass. This study assessed leucine intake and sarcopenia indicators among 181 adults aged 60-80 in Santiago, Chile, participating in the Program for Complementary Food in Older People (PACAM), with 80% being women.

Methods: Sarcopenia was evaluated through muscle strength and mass using the EWGSOP2 criteria for its identification.

In Vitro Evaluation of New 5-Nitroindazolin-3-one Derivatives as Promising Agents against .

Chagas disease is a prevalent health problem in Latin America which has received insufficient attention worldwide. Current treatments for this disease, benznidazole and nifurtimox, have limited efficacy and may cause side effects. A recent study proposed investigating a wide range of nitroindazole and indazolone derivatives as feasible treatments.

Preservative Effect of Alga Flour Extract on Frozen Horse Mackerel () Lipids.

The aim of this study was to investigate the preservative properties of alga sp. flour when included in the glazing medium employed for the frozen storage (-18 °C) of horse mackerel (). Different concentrations (low, medium, and high) of an aqueous extract were tested and compared to a control water-glazing condition.

Osteochondral Autograft Transplantation for Symptomatic Full-thickness Patellar Cartilage Defects in Adolescents.

Background: This study aimed to review the clinical, radiographic, and magnetic resonance imaging (MRI) outcomes of osteochondral autograft transplantation applied to patellar cartilage lesions of patients under 18 years of age.

Methods: Data from nine consecutive patients were retrospectively analyzed for indications, preoperative complications, and clinical-radiographic outcomes. Patients were clinically evaluated using the Pedi-IKDC and Lysholm scores.

Graded association of muscle strength with all-cause and cause-specific mortality in older adults with diabetes: Prospective cohort study across 28 countries.

Background: The worldwide prevalence of diabetes is increasing, particularly among older adults. Understanding the association between muscle strength and mortality in this population is crucial for developing targeted exercise recommendations.

Objectives: To assess the prospective association of muscle strength with mortality in older adults with diabetes.

Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years.

Background: Determining the postmortem interval (PMI) accurately remains a significant challenge in forensic sciences, especially for intervals greater than 5 years (late PMI). Traditional methods often fail due to the extensive degradation of soft tissues, necessitating reliance on bone material examinations. The precision in estimating PMIs diminishes with time, particularly for intervals between 1 and 5 years, dropping to about 50% accuracy.

Vocal Fold Dissipated Power in Females with Hyperfunctional Voice Disorders.

Objective: Phonotrauma has been hypothesized to be associated with prolonged and/or accumulated biomechanical stress on vocal fold tissue. This hypothesis can be tested using ambulatory monitoring of vocal fold dissipated power, which requires a reliable method for its noninvasive estimation during the activity of daily living. The first aim of this study was to show that a laboratory-based estimate of vocal fold dissipated power computed from intraoral pressure (IOP) has significant discriminative power in individuals with phonotraumatic vocal hyperfunction (PVH).

Ethnic diversity in Chilean blood groups: A comprehensive analysis of genotypes, phenotypes, alleles and the immunogenic potential of antigens in northern, southern and central regions.

Background And Objectives: The available information on blood groups in the Chilean population is derived from studies on aboriginal cohorts and routine serological test results. The purpose of this study is to conduct a comprehensive analysis of genotypes, phenotypes and blood group alleles in donors from northern, central and southern Chile using molecular methods.

Materials And Methods: Overall, 850 samples from donors in northern, central and southern Chile were genotyped.

Predictors of symptomatic relief in water vapor thermal therapy for prostatic hyperplasia: 36-month prospective study.

Purpose: Existing literature lacks an analysis of factors predicting the achievement of minimum clinically important differences (MCID) after water vapor thermal therapy (WVTT) for prostatic hyperplasia. This study aims to identify these predictors over a 36-month post-WVTT period.

Methods: This prospective single surgeon case series assessed male patients receiving WVTT.