Fixed start method for repetitive project scheduling with simulated annealing.

This research deals with the high project completion variability by presenting a new method to decrease such variability in repetitive construction projects. To achieve this, a Fixed Start Method (FSM) -where the starts of each activity with a high level of probabilistic confidence for the planned project duration are fixed- was applied, where the high level of probabilistic confidence obtained was optimized with the use of the metaheuristic algorithm called Simulated Annealing (SA). This procedure evaluated the project completion in a case study based on the coefficient of variance (COV) of the resulting standard deviation, mean, and temperature selected for the SA.

COVID-19, Autism, and Isolation: Good Practices for Continuity of Care During the Pandemic.

The COVID-19 pandemic, and particularly the associated conditions of isolation, has detrimental effects on the mental health of the population that are not yet fully understood. Variables such as individual stress, anxiety, and tolerance to uncertainty may play a role in the ability of individuals to adapt to the isolation situation. In this context, it is necessary to pay attention to population groups that present difficulties in adapting to this situation of uncertainty, such as people with autism.

Is lean mass quantity or quality the determinant of maximal fat oxidation capacity? The potential mediating role of cardiorespiratory fitness.

Background: Impaired fat oxidation is linked to cardiometabolic risk. Maximal fat oxidation rate (MFO) reflects metabolic flexibility and is influenced by lean mass, muscle strength, muscle quality - defined as the ratio of strength to mass - and cardiorespiratory fitness. The relationship between these factors and fat oxidation is not fully understood.

Glucagon like peptide-1 (GLP-1) agonists and cardiometabolic protection: historical development and future challenges.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of cardiometabolic diseases, extending their therapeutic applications far beyond glycemic control in type 2 diabetes (T2D) and obesity. This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential.

The benefit of national clinical guidelines for open lower limb fractures in reducing healthcare burden: A length of inpatient stay cost-analysis.

Introduction: Severe open lower limb fractures are complex and costly injuries. Studies reporting the costs associated with these injuries, the economic impact of complications, and the clinical benefit of adherence to national guidelines have been previously reported. However, the economic benefits of national guidelines and their relationship with length of inpatient stay have not been described.

Efficacy, immunogenicity, and safety of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine.

Background: In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine (RSVPreF3-Mat), a higher rate of preterm birth was observed in the vaccine (6.8%) versus the placebo group (4.9%).

Statistical analysis plan for hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock: the ANDROMEDA-SHOCK-2 randomized clinical trial.

Background: ANDROMEDA-SHOCK 2 is an international, multicenter, randomized controlled trial comparing hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock to standard care resuscitation to test the hypothesis that the former is associated with lower morbidity and mortality in terms of hierarchal analysis of outcomes.

Objective: To report the statistical plan for the ANDROMEDA--SHOCK 2 randomized clinical trial.

Methods: We briefly describe the trial design, patients, methods of randomization, interventions, outcomes, and sample size.

One-minute sit-to-stand test: Reference values for the Chilean population.

Introduction: The one-minute sit to stand test (1min-STST) is a field test used to assess functional capacity. It is easily implementable and of significant clinical utility; however, no reference values are currently available for the Chilean population. The objective of this study was to establish reference values for the 1min-STST in a healthy Chilean population.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

CMRxRecon2024: A Multimodality, Multiview k-Space Dataset Boosting Universal Machine Learning for Accelerated Cardiac MRI.

. The released CMRxRecon2024 dataset is currently the largest and most protocol-diverse publicly available k-space dataset including multi-modality and multi-view cardiac MRI data from 330 healthy volunteers, and each one covers standardized and commonly used clinical protocols. ©RSNA, 2025.

The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances.

In 1963, Eduardo Lissi and Juan Grotewold started a chemical kinetics and photochemistry group at the School of Sciences at the University of Buenos Aires (Facultad de Ciencias Exactas y Naturales, FCEN, UBA). Political circumstances in Argentina and in Chile were a great determinant of the evolution, dispersion, and re-encounters of the group members. The initial graduate students in the group developed their own research groups working in various Countries and on a variety of projects.

"It's that feeling that you can't get away": Motherhood, gender inequality and the stress process during extreme events.

The impacts of extreme events can intersect with pre-disaster systemic inequalities and deficiencies, exacerbating distress. This paper contributes to the existing literature by exploring the psychosocial processes through which stressors become traumatic during an extreme event. It does so by focusing on how mothers of children and/or adolescents in the United Kingdom experienced the COVID-19 pandemic.

Transitions through the HIV continuum of care in people enrolling in care with advanced HIV disease in Latin America.

Objectives: Advanced HIV disease (AHD) at HIV care enrollment is common in Latin America and may bias cross-sectional care continuum estimates. We therefore explored the impact of AHD on HIV care continuum outcomes using a longitudinal approach.

Methods: We analyzed trajectories of 26,174 adult people with HIV enrolled at Caribbean, Central and South America network for HIV epidemiology (CCASAnet) sites (2003-2019) using multi-state Cox regression across five stages: (i) enrolled without antiretroviral therapy (no-ART); (ii) on ART without viral suppression (viral load ≥200 copies/m; ART + non-VS); (iii) on ART with viral suppression (viral load <200 copies/ml; ART + VS); (iv) lost to follow-up; (v) death.

Dynamics of automated body condition scores in grazing Holstein cows in a year-round calving system.

This observational study aimed to characterize the seasonal dynamics of automated BCS throughout the lactation of Holstein cows in a pasture-based system with year-round calvings. Examining the association between nadir BCS (nBCS; defined as the lowest daily BCS after calving) and peak milk yield within each calving period (calendar seasons equally divided in early and late) was a secondary objective of this research. Retrospective data included 2,164 lactations in 539 primiparous (PRI) and 1,625 multiparous (MLT) Holstein cows that calved from July 2021 to June 2023 in a commercial dairy farm located in Southern Chile.

A faunal inventory of methane seeps on the Pacific margin of Costa Rica.

The methane seeps on the Pacific margin of Costa Rica support extensive animal diversity and offer insights into deep-sea biogeography. During five expeditions between 2009 and 2019, we conducted intensive faunal sampling via 63 submersible dives to 11 localities at depths of 300-3600 m. Based on these expeditions and published literature, we compiled voucher specimens, images, and 274 newly published DNA sequences to present a taxonomic inventory of macrofaunal and megafaunal diversity with a focus on invertebrates.

Reductive acetogenesis is a dominant process in the ruminant hindgut.

Background: The microbes residing in ruminant gastrointestinal tracts play a crucial role in converting plant biomass to volatile fatty acids, which serve as the primary energy source for ruminants. This gastrointestinal tract comprises a foregut (rumen) and hindgut (cecum and colon), which differ in structures and functions, particularly with respect to feed digestion and fermentation. While the rumen microbiome has been extensively studied, the cecal microbiome remains much less investigated and understood, especially concerning the assembling microbial communities and overriding pathways of hydrogen metabolism.

Exploring Oral Narrative Abilities of Chilean School-Age Children With Down Syndrome: A Preliminary Study.

Narrative abilities are essential for school achievement and quality of life, yet children with Down syndrome (DS) often struggle with these skills. This work explores the oral narrative abilities of school-age Chilean children with DS. The participants were 11 children with DS aged between 7;2 and 12;1 (years; months).

Changes to social and healthcare providers support in the perinatal period: Impact on coping strategies, depression and anxiety.

Background: During the perinatal period, risk of depression and anxiety (D&A) increases. As in other crisis events, the COVID-19 pandemic, imposed social distancing measures, diminished social support and changes in perinatal healthcare provision which heightened this risk. This study aimed to examine how changes in social and healthcare provider support during the pandemic affected coping strategies and depression and anxiety symptoms (D&As) among perinatal women.

Corticosteroids in severe alcohol-associated hepatitis? Not so fast: A systematic review of randomized controlled trials.

Background: Severe alcohol-associated hepatitis (AH) is rising in incidence with a high mortality burden. While corticosteroids are recommended for eligible patients with severe AH, no guidance exists for the timing of steroid initiation, tapering regimens, and surveillance of adverse events.

Objective: We aim to systematically review these variables and provide evidence-based recommendations for the inpatient and outpatient management of severe AH.

Description of six novel species sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov., isolated from mangrove ecosystem.

Six Gram-stain-positive and rod-shaped strains, designated FJAT-51614, FJAT-51639, FJAT-52054, FJAT-52991, FJAT-53654 and FJAT-53711, were isolated from a mangrove ecosystem. The condition for growth among the strains varied (pH ranging 5.0-11.

In this current wildfire crisis, acknowledge widespread suffering.

With climate change causing more extreme weather events globally, climate scientists have argued that societies have three options: mitigation, adaptation or suffering. In recent years, devastating wildfires have caused significant suffering, yet the extent of this suffering has not been defined. To encapsulate this suffering, we determined impacts and effects of extreme wildfires through two systematic literature reviews.

LAPS SA: Measuring Attachment to Dogs and Cats Among South American Countries.

Human biological and cultural evolution is tied to the relationships established with other animals. Attachment is one of the mechanisms established between dogs/cats and humans and allows the generation of affective bonds and close proximity. Many instruments have been used to study attachment of people to their dogs/cats, such as the Lexington Attachment to Pets Scale (LAPS).

Evaluating the Effectiveness of a Culturally Adapted Dementia Prevention Animation on Ethnically Diverse participants' Knowledge of Dementia Prevention.

Objectives: To determine whether culturally adapted dementia prevention animations increased dementia prevention knowledge in ethnically diverse communities.

Methods: A before-and after survey conducted online and in-person between 1 February and 5 June 2022. Participants viewed the animation in Arabic, Hindi, Tamil, Cantonese, Mandarin, Greek, Italian, Spanish, Vietnamese or English.