4 results match your criteria: "University of Chieti "G. d'Annunzio". c.dinisio@unich.it.[Affiliation]"
Central inhibitory effects on feeding induced by the adipo-myokine irisin.
Eur J Pharmacol
November 2016
Department of Pharmacy, "G. d'Annunzio" University, via dei Vestini 31, 66013 Chieti, Italy. Electronic address:
Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1μl, 50-200nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats.
View Article and Find Full Text PDFTranscriptome modifications in human gingival fibroblasts exposed to 2-hydroxyethyl methacrylate.
Gene
May 2016
Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, "G.d'Annunzio" University, Via Dei Vestini 31, 66100 Chieti-Pescara, Italy; Center of Excellence on Aging, "G.d'Annunzio" University, Via L. Polacchi, 66100 Chieti-Pescara, Italy. Electronic address:
2-Hydroxyethyl methacrylate (HEMA),a tooth filling material, was proven to have toxic effects on different cell types, including human gingival fibroblasts (HGFs), and to be able to influence odontoblast vitality. The aim of the present study was to assess the differential transcriptome modulation induced by low HEMA concentration in cultured HGFs. RNA extracted from cultured HGFs exposed to 3 mmol/l HEMA for 24 or 96 h underwent a whole genome microarray analysis.
View Article and Find Full Text PDFOsteonecrosis of the jaw (ONJ) is a chronic complication affecting long-term bisphosphonate-treated subjects, recognized by non-healing exposed bone in the maxillofacial region. The pathophysiological mechanism underlying ONJ has not been fully elucidated. The aim of the present study was to investigate the role of RANK/RANKL/OPG signaling pathway and, in parallel, to evaluate angiogenic and matrix mineralization processes in jaw bone necrotic samples obtained from bisphosphonate-treated subjects with established ONJ.
View Article and Find Full Text PDFPeripheral chemerin administration modulates hypothalamic control of feeding.
Peptides
January 2014
Department of Pharmacy, "G. d'Annunzio" University, via dei Vestini 31, 66013 Chieti, Italy. Electronic address:
Article Synopsis
- Chemerin is a newly identified protein that influences fat production, energy use, and inflammation, and this study aimed to assess its effects on food intake and body weight in rats.
- Adult Wistar rats were injected with different doses of chemerin or a saline control over 17 days, and their food consumption was tracked; after treatment, their hypothalamic tissues were analyzed for specific gene expressions linked to appetite regulation.
- Results showed that chemerin reduced food intake and body weight in rats, likely due to increased serotonin levels in the hypothalamus, but its impact on gene expression suggests that chemerin may not be a major appetite-regulating signal in the body.