Whole exome sequencing in recurrent early pregnancy loss.

Study Hypothesis: Exome sequencing can identify genetic causes of idiopathic recurrent pregnancy loss (RPL).

Study Finding: We identified compound heterozygous deleterious mutations affecting DYNC2H1 and ALOX15 in two out of four families with RPL. Both genes have a role in early development.

Turbulent mixing and beyond: non-equilibrium processes from atomistic to astrophysical scales II.

This Introduction summarizes and provides a perspective on the papers representing one of the key themes of the 'Turbulent mixing and beyond' programme--the hydrodynamic instabilities of the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) type and their applications in nature and technology. The collection is intended to present the reader a balanced overview of the theoretical, experimental and numerical studies of the subject and to assess what is firm in our knowledge of the RT and RM turbulent mixing.

Unmet therapeutic needs for uterine myomas.

Uterine myomas may develop in many women, but only become clinically significant in about one third of the affected population. Although uterine myomas are most often benign, they are associated with debilitating symptoms and commonly result in hysterectomy. Current treatments for uterine myomas include pharmacologic therapies, delivery of focused energy, alteration of uterine vascular supply, or surgical procedures.

Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy.

Purpose: To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10 and 20 Gy or more (PBM-V(10) and PBM-V(20)) is associated with acute hematologic toxicity (HT) in anal cancer patients treated with concurrent chemoradiotherapy.

Methods And Materials: We analyzed 48 consecutive anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiation therapy. The median radiation dose to gross tumor and regional lymph nodes was 50.