3,258 results match your criteria: "University of Castilla-La-Mancha[Affiliation]"

Introduction: Attitudes and beliefs guide our decision-making. In the educational context, prior research has noted the existence of prejudices and stereotypes among teachers that make it difficult to identify and care for gifted students. Stereotypes towards gifted students can hinder the identification and development of potential and the development of personality.

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Mean middle cerebral artery velocity (MCAv) and the pulsatility index (PI), at rest and in response to exercise, are important markers of cerebrovascular health status in middle-aged adults, when vascular decline assumes substantial relevance. Thus, this study aimed to describe and compare the responses of MCAv and PI to incremental exercise. Two hundred and forty-eight volunteers (50-58 years, 55% women) completed a ramp test on a cycle-ergometer.

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Introduction: Despite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dose of the BNT162b2 mRNA COVID-19 vaccine.

Methods: A prospective longitudinal study was conducted at University General Hospital of Albacete, involving 38 healthy health-care workers.

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Anatomy, histology and ultrastructure of the adult human olfactory peduncle: Blood vessel and corpora amylacea assessment.

Tissue Cell

January 2025

Neurogenesis and Neurostereology laboratory, Biomedicine Institute-UCLM, Institute of Health Research of Castilla-La Mancha (IDISCAM), University of Castilla-La Mancha, Albacete, Spain. Electronic address:

The mammalian olfactory system is responsible for processing environmental chemical stimuli and comprises several structures, including the olfactory epithelium, olfactory bulb, olfactory peduncle (OP), and olfactory cortices. Despite the critical role played by the OP in the conduction of olfactory information, it has remained understudied. In this work, optical, confocal, and electron microscopy were employed to examine the anatomy, histology, and ultrastructure of six human OP specimens (ages 37-84 years).

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Objectives: Point-of-care testing available in prehospital settings requires the establishment of new medical decision points. The aim of the present work was to determine the cut-off of the lactate threshold that activates alert triggers for all-cause 2-day mortality.

Design: Multicentre, prospective, ambulance-based, observational study.

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Anatomical dissection influences emotions of podiatry students.

J Foot Ankle Res

March 2025

Department of Medical Sciences, Faculty of Health Sciences, Research Group Technological Innovation Applied to Health (ITAS), University of Castilla-La Mancha, Talavera de la Reina, Toledo, Spain.

Background: Dissection and examination of prosected cadavers is a tool for teaching anatomy. However, this experience can provoke anxiety and stress among students. This study aims to understand the attitudes, reactions, fears, and anxiety states of podiatry students before their first dissection in addition to evaluate its usefulness as an educational tool for academic training in anatomy.

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Compared to aziridines, azaphosphiridines, which formally result from the replacement of a carbon atom by phosphorus, have been much less studied. In this work, accurate values for one of the most prominent properties, the ring strain energy (RSE), have been theoretically examined for a wide range of azaphosphiridine derivatives. Strongly related aspects of interest for developing the use of azaphosphiridines in heteroatom and polymer chemistry are ring opening reactions and polymerisations, the latter facilitated by their significantly high RSE.

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Objective: The objective of this study is to analyse the perspectives of screening candidates and healthcare professionals on shared decision-making (SDM) in prostate cancer (PCa) screening using the prostate-specific antigen (PSA) test.

Design: Descriptive qualitative study (May-December 2022): six face-to-face focus groups and four semistructured interviews were conducted, transcribed verbatim and thematically analysed using ATLAS.ti software.

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National early warning score 2 plus non-invasive capnography and perfusion index to estimate poor outcomes in emergency departments.

Am J Emerg Med

January 2025

Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Emergency Department, Hospital Clínico Universitario, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain.

Background: The study of the inclusion of new variables in already existing early warning scores is a growing field. The aim of this work was to determine how capnometry measurements, in the form of end-tidal CO2 (ETCO2) and the perfusion index (PI), could improve the National Early Warning Score (NEWS2).

Methods: A secondary, prospective, multicenter, cohort study was undertaken in adult patients with unselected acute diseases who needed continuous monitoring in the emergency department (ED), involving two tertiary hospitals in Spain from October 1, 2022, to June 30, 2023.

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Cut-Off Points for Low Relative 30-s Sit-to-Stand Power and Their Associations With Adverse Health Conditions.

J Cachexia Sarcopenia Muscle

February 2025

Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.

Background: Despite muscle power derived from the 5-rep sit-to-stand (STS) test having been demonstrated to be a valuable biomarker in older individuals, there is limited information regarding muscle power derived from the 30-s STS test, a widely used test in the clinical setting. This study aimed (i) to compare relative 30-s STS power values between older men and women, (ii) to identify cut-off points for low relative 30-s STS power, (iii) to compare the prevalence of low relative STS power between sexes and (iv) to evaluate the association of low relative 30-s STS power with adverse conditions in older people.

Methods: A total of 1475 community-dwelling older adults (65-98 years; 45% men) from the Toledo Study for Healthy Aging were included.

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Uncertainty maps for model-based global climate classification systems.

Sci Data

January 2025

Earth and Space Sciences (ESS) Group, Institute of Environmental Sciences, University of Castilla-La Mancha (UCLM), Avda. Carlos III s/n, 45071, Toledo, Spain.

Climate classification systems (CCSs) are emerging as essential tools in climate change science for mitigation and adaptation. However, their limitations are often misunderstood by non-specialists. This situation is especially acute when the CCSs are derived from Global Climate Model outputs (GCMs).

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Data Analysis Methods in Time-Resolved Fluorescence Spectroscopy: A Tutorial Review.

Chemistry

January 2025

Division of Molecular Imaging and Photonics, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.

Fluorescence spectroscopy and related techniques benefit from exceptional sensitivity and have become engrained in a variety of fields from biosciences to materials sciences. Measuring time-domain fluorescence decays is nowadays a routine task in many laboratories across these different fields. Perhaps surprisingly, a correct data analysis of these fluorescence decay curves presents a formidable challenge and requires extensive insight in the problems associated with fitting this type of data.

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Background: Serum creatinine and estimated glomerular filtration rate (GFR) are key indicators of kidney function.

Methods: This descriptive, retrospective study included neonatal patients admitted to a tertiary hospital's neonatal intensive care unit from January 2013 to December 2016. Data on kidney function were collected from birth to 7 days of life.

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(1) Background: Chronic pain in children remains an under-researched area, especially compared to acute pain. This systematic review aims to evaluate the effectiveness of non-pharmacological interventions in the management of pediatric chronic pain and their impact on the well-being of both children and their families. Given the growing interest in integrative treatments to reduce reliance on pharmacological solutions, this review addresses the need for alternative therapeutic approaches.

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This systematic review aimed to evaluate and synthesize scientific evidence on occupational therapy (OT) interventions focused on leisure activities to improve activities of daily living (ADLs) and cognitive function in middle-aged and older people with mild cognitive impairment (MCI). A systematic review was carried out following the guidelines established by the PRISMA statement. The study was registered in the PROSPERO database.

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We aimed to determine the persisting effects of various exercise modalities and intensities on functional capacity after periods of training cessation in older adults. A comprehensive search was conducted across the Cochrane Library, PubMed/MEDLINE, Scopus, and Web of Science Core Collection up to March 2024 for randomized controlled trials examining residual effects of physical exercise on functional capacity in older adults ≥ 60 years. The analysis encompassed 15 studies and 21 intervention arms, involving 787 participants.

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Unnecessary preoperative testing poses a risk to patient safety, causes surgical delays, and increases healthcare costs. We describe the effects of implementing a fully EHR-integrated closed-loop clinical decision support system (CDSS) for placing automatic preprocedural test orders at two teaching hospitals in Madrid, Spain. Interrupted time series analysis was performed to evaluate changes in rates of preoperative testing after CDSS implementation, which took place from September 2019 to December 2019.

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Circulating Exosomal MicroRNAs and Subclinical Atherosclerosis in Obstructive Sleep Apnea.

Arch Bronconeumol

December 2024

Precision Medicine in Respiratory Diseases Group, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria de Aragón (IISAragón), Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERes), Madrid, Spain; Respiratory Service, Hospital Universitario Miguel Servet, University of Zaragoza, Zaragoza, Spain.

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Objectives: To estimate the excess formal social costs or direct non-healthcare costs of dementia-related neuropsychiatric symptoms (NPS).

Methods: The presence of dementia, NPS, antipsychotic and antidepressant use, somatic and psychiatric comorbidities, and formal social benefits were studied in a regionwide cohort of all 60-year-old and older individuals. A random forest-based algorithm identified NPS, and 2-part regression models and entropy balance were used.

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