Relationship between non-syndromic oral clefts and cancer: A systematic review and meta-analysis.

Objective: To summarize the clinical evidence on the relationship between cancer and non-syndromic oral cleft (NSOC).

Methods: The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist, and a literature search was conducted in six databases and gray literature. Studies published in any language mentioning cancer in patients with NSOC and their relatives and NSOC in patients with cancer and their relatives were included.

Tumor microenvironment in salivary gland carcinomas: An orchestrated state of chaos.

Salivary gland carcinomas (SGC) are rare tumors of heterogeneous morphology and many histological subtypes. Like other tumors, the SGC mass consists of a varied population of malignant cells and a diverse array of immune cells, cancer-associated fibroblasts, cytokines, chemokines, extracellular matrix proteins, and metalloproteinases, collectively known as the tumor microenvironment (TME). This chaotic network serves as an important physical mediator of cancer cell growth.

Evaluation of genome-wide association signals for nonsyndromic cleft lip with or without cleft palate in a multiethnic Brazilian population.

Objective: To evaluate previous nonsyndromic cleft lip with or without cleft palate (NSCL±P) associated signals in 4p16.2, 8p11.23, 12q13.

Evaluation of the economic impact of COVID-19 on Brazilian private dental clinics: A cross-sectional study.

Background: The changes in dental care in the face of the COVID-19 pandemic resulted in the need for greater financial investment by dentists in biosafety measures and increase in the costs of dental consultations.

Objective: To evaluate the economic impact of the COVID-19 pandemic on dental practices in private clinics in Brazil.

Methods: A cross-sectional study was carried out, using an online questionnaire indexed in Google Forms, and distributed among dentists.

Candida species biotypes and polyclonality of potentially virulent Candida albicans isolated from oral cavity of patients with orofacial clefts.

Objectives: This study evaluated the incidence of Candida species, and the genetic diversity and virulence of C. albicans of the oral cavity from patients with cleft lip and palate (CLP).

Materials And Methods: Oral samples were investigated by microbiological and species-specific PCR methods.

Oral Juvenile Xanthogranuloma: A Clinicopathological, Immunohistochemical and BRAF V600E Study of Five New Cases, with Literature Review.

Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis and oral mucosal involvement is exceedingly rare. Histiocytic disorders harbor activating mutations in MAPK pathway, including the report of BRAF V600E in JXG of extracutaneous site. However, no information is available for oral JXG.

Clinical and Radiographic Outcomes of Regenerative Endodontic Procedures in Traumatized Immature Permanent Teeth: Interappointment Dressing or Single-Visit?

Introduction: More data are needed before affirming that single-visit approaches are effective and safe for regenerative endodontic procedures (REPs). This study compared clinical and radiographic outcomes of REPs between interappointment dressing or single-visit protocols.

Methods: Twenty young patients presenting traumatized immature teeth with pulp necrosis were divided into 2 groups.

Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients With Non-syndromic Cleft Palate Only.

The identification of genetic risk factors for non-syndromic oral clefts is of great importance for better understanding the biological processes related to this heterogeneous and complex group of diseases. Herein we applied whole-exome sequencing to identify potential variants related to non-syndromic cleft palate only (NSCPO) in the multiethnic Brazilian population. Thirty NSCPO samples and 30 sex- and genetic ancestry-matched healthy controls were pooled (3 pools with 10 samples for each group) and subjected to whole-exome sequencing.

Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation.

Objective: The aim of this study was to evaluate the expression of BPIFA proteins in the saliva and salivary glands of hematopoietic cell transplant (HCT) patients.

Material And Methods: This longitudinal study included patients who had undergone autologous HCT (auto-HCT) and allogeneic HCT (allo-HCT), and unstimulated saliva was collected at three time points, with a fourth collection at oral chronic graft-versus-host disease (cGVHD) onset. BPIFA expression was analysed by Western blotting in saliva and immunostaining in the minor salivary glands of cGVHD patients.

Influence of luting space of zirconia abutment on marginal discrepancy and tensile strength after dynamic loading.

Statement Of Problem: Although luting space is related to the marginal fit of indirect restorations, information on its influence on the marginal fit and tensile strength of zirconia abutments bonded to titanium bases is lacking.

Purpose: The purpose of this in vitro study was to evaluate the influence of luting space on the marginal discrepancy and tensile strength of zirconia abutments bonded to a titanium base after dynamic loading.

Material And Methods: Ninety implant replicas were embedded in resin blocks to attach 4-mm-high titanium luting bases.

M1 macrophages involved in the pathogenesis of placental chronic villitis of unknown etiology.

Introduction: Placental villitis is characterized by the presence of inflammatory infiltrate in the placental villous. The objective of this study was to characterize in villitis of unknown etiology (VUE) of the human placentas the subpopulation of M1, important effector cells, and M2 macrophages, immunoregulatory cells.

Methods: Sixteen cases of VUE and three control placentas were examined using immunohistochemistry with antibodies for CD3, CD68, CD11c, and CD163.

Incidence of Shiga toxin-producing in diarrheic calves and its susceptibility profile to antimicrobials and L.

The aim of this study was to evaluate the occurrence of Shiga toxin -producing (STEC) in diarrheic newborn calves, as well as the resistance profile of this microorganism against antimicrobials routinely used in veterinary therapy. The antimicrobial profile of against clinical isolates was also analyzed. Specimens from the recto-anal junction mucosa were investigated by using chromogenic medium and identification of was done using microbiological methods (Gram staining, indole test, methyl red test, Voges-Proskauer test, citrate test, urease test, and hydrogen sulfide test).

Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development.

The myoepithelial cell seems to play an important role as a tumor suppressor in the development of carcinoma ex pleomorphic adenoma. Nevertheless, interesting aspects concerning the other side of the coin, i.e.

Amphotericin B, fluconazole, and nystatin as development inhibitors of Candida albicans biofilms on a dental prosthesis reline material: Analytical models in vitro.

Statement Of Problem: The use of antifungals has been suggested during the treatment of denture stomatitis associated with Candida albicans biofilms. However, how time, material surface, and substrates present during adhesion and biofilm development can influence clinical treatment is unclear.

Purpose: The purpose of this in vitro study was to investigate the growth kinetics of C.

DNA microsatellite genotyping of potentially pathogenic Candida albicans and C. dubliniensis isolated from the oral cavity and dental prostheses.

This study investigated the incidence, genetic diversity, antifungal sensitivity, and virulence of Candida albicans and C. dubliniensis isolated from subjects using dental prostheses and subjects clinically indicated for the first prosthetic rehabilitation. Subjects were divided into four groups and samples were collected twice: at first rehabilitation by removable partial (A) and total (C) dental prostheses, and replacement of the removable partial (B) and total (D) prostheses.

Physical and psychological states interfere with health-related quality of life of institutionalized elderly: a cross-sectional study.

Background: Nursing home elders experience many problems that may influence their quality of life, in example of cognitive, mental, nutritional and physical disabilities. Concerning about elders' wellbeing may help them living with dignity. This study aimed to investigate factors associated with Health-Related Quality of Life (HRQoL) of institutionalized elders in a capital city of Brazilian Northeast.

Acupuncture as a therapeutic resource for treatment of chronic pain in people with haemophilia.

Introduction: Chronic pain is common in individuals with severe and moderate haemophilia who did not receive prophylaxis during childhood.

Objective: To verify the effectiveness of acupuncture in reducing intensity in chronic pain, changes in quality of life, joint function and impact on treatment satisfaction of haemophilia patients.

Methods: Single-blinded randomized clinical trial with 28 participants divided into two groups: Acupuncture (G1) treated with traditional unilateral acupuncture (side of greatest referred pain) and Control (G2) treated with transcutaneous electrical nerve stimulation (TENS), with electrodes on the joint of most intense pain.

Misfit detection in implant-supported prostheses of different compositions by periapical radiography and cone beam computed tomography: An in vitro study.

Statement Of Problem: Misfits at the implant-abutment joint (IAJ) can cause the biological and mechanical failure of implant therapy. Standard parallel periapical radiography (PERI) is the method of choice for assessing the fitting of implant-supported prostheses. Although current guidelines do not support the use of cone beam computed tomography (CBCT) solely for misfit detection, CBCT scans can also register misfits as imaging findings.

Objective assessment of the combined effect of exomass-related- and motion artefacts in cone beam CT.

Objectives: To assess quantitatively the combined effect of exomass-related- and motion artefacts on voxel value parameters in cone beam CT (CBCT).

Methods: A cylindrical phantom was manufactured, containing 21 tubes filled with a radiopaque solution, allowing the inclusion of three titanium implants in the periphery to induce exomass-related artefacts. The phantom was mounted on a robot simulating 0.

Eruption sequestrum: an inflamed odontogenic hamartoma.

Eruption sequestrum (ES) is a single or even multiple, small whitish calcified masses found within the soft tissue of the opercula overlying the crown of erupting permanent molars of children. We herein report a well-documented case of ES, offering a review of published cases in the English literature. An otherwise healthy 6-year-old girl was seen for routine dental examination.