1,582 results match your criteria: "University of California-San Francisco School of Medicine.[Affiliation]"

Case report: sub-clinical extramedullary B-ALL in the setting of relapse following targeted therapy.

Front Immunol

October 2024

Division of Pediatric Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford Medicine, Stanford, San Francisco, CA, United States.

Article Synopsis
  • Standard testing for B-cell acute lymphoblastic leukemia (B-ALL) typically involves examining the bone marrow and cerebrospinal fluid, with imaging used in cases of suspected extramedullary disease, although not routinely for relapsed/refractory cases.
  • This text discusses two patients with relapsed/refractory B-ALL who had previously received treatments and were assessed to only have minimal residual disease (MRD) before CAR-T cell therapy.
  • Both patients underwent PET-MRI scans before treatment, which unexpectedly revealed significant extramedullary disease, necessitating adjustments in their clinical management and emphasizing the need for more thorough imaging studies in future B-ALL treatment protocols.
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  • Tranexamic acid (TXA) is used in adult spinal deformity surgery to reduce blood loss, but there's no agreed-upon dosing method.
  • A study analyzed data from 265 complex ASD patients, categorizing them into low, medium, and high TXA dose groups and measuring blood loss, complications, and RBC transfusions.
  • Findings revealed that lower TXA doses resulted in significantly higher blood loss and increased RBC transfusions compared to high doses, suggesting that higher TXA dosing may be more effective in minimizing blood loss during surgery.
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Transitioning into trauma-focused evidence-based psychotherapy for posttraumatic stress disorder from other treatments: a qualitative investigation.

Cogn Behav Ther

October 2024

Mental Health Service, San Francisco Veterans Affairs Health Care System, 4150 Clement Street, San Francisco, CA 94121, USA.

Although trauma-focused evidence-based psychotherapy (TF-EBP) is recommended for posttraumatic stress disorder (PTSD), rates of TF-EBP initiation among veterans is very low. Service delivery research has shown that other treatments are commonly provided to veterans diagnosed with PTSD, including stabilization treatments. As little is known about how veterans experience the transition to TF-EBP, we conducted a qualitative examination of veterans' perspectives on transitions in PTSD treatment.

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The San Francisco Health Systems Collaborative: Public Health and Health Care Delivery Systems' Response to the Covid-19 Pandemic.

NEJM Catal Innov Care Deliv

August 2024

Director of Health, City and County of San Francisco, San Francisco, California, USA.

The Covid-19 pandemic challenged health care delivery systems worldwide. Many acute care hospitals in communities that experienced surges in cases and hospitalizations had to make decisions such as rationing scarce resources. Hospitals serving low-income communities, communities of color, and those in other historically marginalized or vulnerable groups reported the greatest operational impacts of surges.

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School Suspension and Expulsion: Policy Statement.

Pediatrics

October 2024

Division of General Pediatrics, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Exclusionary school discipline practices-ie, suspension and expulsion-represent some of the most severe consequences a school district can implement for unacceptable student behavior. Suspension and expulsion were traditionally used for student behaviors that caused serious harm, such as bringing a weapon to school. Currently, the most common indications for exclusionary school discipline are for behaviors that are neither violent nor criminal.

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Objective(s): Posterior pharyngeal wall (PPW) injection is often employed to treat velopharyngeal deficiency (VPD). We sought to analyze the impact of PPW injection on severity of dysphagia and dysphonia.

Methods: Retrospective chart review was conducted of patients undergoing PPW injection from 2018 to 2023 at a tertiary laryngology center.

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  • SCID is a serious illness that affects the immune system and can be deadly without special treatments like cell transplants or gene therapy.
  • Newborn screening for SCID has helped many babies survive, but we need to learn more about the long-term health effects on those who survive.
  • Researchers are studying how different factors, like the type of treatment and health history, can impact the long-term health of SCID survivors, and they want to improve care for these patients in the future.
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To evaluate the association between initial management strategy of neonatal symptomatic Tetralogy of Fallot (sTOF) and later health-related quality of life (HRQOL) outcomes. We performed a multicenter, cross-sectional evaluation of a previously assembled cohort of infants with sTOF who underwent initial intervention at ≤ 30 days of age, between 2005 and 2017. Eligible patients' parents/guardians completed an age-appropriate Pediatric Quality of Life Inventory, a Pediatric Quality of Life Inventory Cardiac Module Heart Disease Symptoms Scale, and a parental survey.

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  • The study aimed to measure retinal capillary blood flow velocity and acceleration in nonhuman primates and humans using two imaging techniques: erythrocyte mediated angiography (EMA) and optical coherence tomography angiography (OCTA).
  • The research involved conducting scans on 2 NHPs and 11 humans, measuring the velocity of blood flow in different types of capillary networks and assessing the effects of elevated intraocular pressure (IOP) on this flow.
  • Results showed that while baseline capillary blood flow velocities were different between species, increasing IOP significantly reduced blood flow velocity in capillaries, indicating that IOP affects retinal blood dynamics.
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The Rho Kinase (ROCK) pathway is recognized to be involved in changes that lead to remodeling in pulmonary hypertension (PH), particularly cellular processes including signaling, contraction, migration, proliferation, differentiation, and apoptosis. Simvastatin (Sim) has a potent anti-proliferative and pro-apoptotic effect on vasculature smooth muscle cells through the inhibition of the synthesis of isoprenoids intermediates which are essential for the post-translational isoprenylation of Rho, Rac, and Ras family GTPases. Sim targets the underlying mechanism in vascular remodeling.

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The researcher's guide to selecting biomarkers in mental health studies.

Bioessays

October 2024

Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Article Synopsis
  • Clinical mental health researchers often find it challenging to integrate biological assessments into their studies due to the complexity of the existing literature.
  • This paper offers guidelines to help researchers focus on biological pathways in their research, which can enhance understanding of mental health mechanisms and inform personalized treatment strategies.
  • The authors discuss the relevance and reliability of peripheral biomarkers, explore five types of biological tissues (blood, saliva, urine, stool, and hair), and offer strategies to manage measurement variability.
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Open Access Data Repository and Common Data Model for Pulse Oximeter Performance Data.

medRxiv

August 2024

Department of Anesthesia and Perioperative Care, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco.

The OpenOximetry Repository is a structured database storing clinical and lab pulse oximetry data, serving as a centralized repository and data model for pulse oximetry initiatives. It supports measurements of arterial oxygen saturation (SaO2) by arterial blood gas co-oximetry and pulse oximetry (SpO2), alongside processed and unprocessed photoplethysmography (PPG) data and other metadata. This includes skin color measurements, finger diameter, vital signs (e.

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This study examined concordance of family members' perspectives of family functioning and mental health across two years in families with transgender and/or nonbinary youth (TNBY). Participants were 89 family members (30 TNBY, age 13-17 years; 44 cisgender caregivers; 15 cisgender siblings, age 14-24 years) from 30 families from the U.S.

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Despite legal protections guaranteeing care for patients with trauma, disparities exist in patient outcomes. We review disparities in patient management and outcomes related to insurance status, race and ethnicity, and gender for patients with trauma in the preadmission, in-hospital, and postdischarge settings. We highlight groups understudied and either underrepresented or unrepresented in national trauma databases-including American Indians/Alaska Natives, non-English preferred patients, and patients with disabilities.

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Objective:  Studies outside of obstetrics suggest that patient-provider language concordance may impact the efficacy of educational interventions and overall patient satisfaction. Many pregnant patients who present to the hospital for delivery with initial plans to exclusively breastfeed ultimately leave the hospital supplementing with formula. We aim to examine the impact of language concordance between patients and their primary bedside nurse during the delivery hospitalization period on the relationship between intended and actual feeding practices for term newborns of primiparous patients at a single institution.

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  • Parents often have mixed emotional reactions to congenital melanocytic nevi (CMN), experiencing feelings ranging from guilt to positivity.
  • Families with prior knowledge of CMN generally report lower stress levels and can benefit from dermatologist referrals for additional learning.
  • Dermatologists can enhance care by using open-ended questions to gauge family emotions and providing targeted information and resources early in the child's life.
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Introduction: Limited information exists regarding the association between resident surgical case experience and subsequent case mix in practice. We compare the case log distribution residents completed during their chief year to those completed by these graduates in their first 2 years in independent practice.

Methods: Resident chief year case logs from 10 institutions were analyzed across 4 categories of index procedures: (1) general urology, (2) endourology, (3) reconstructive urology, and (4) urologic oncology.

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Avoiding common pitfalls in mixed methods research?

Adv Health Sci Educ Theory Pract

September 2024

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Nanyang Ave, Singapore, Singapore.

This column is intended to address the kinds of knotty problems and dilemmas with which many scholars grapple in studying health professions education. In this article, the authors focus on how to help mentees take an analytic approach to improve their mixed methods work. Mixed methods research has increased in popularity and with that comes both strengths and weaknesses in these studies.

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Technical article: Overview of hospital-based data capture systems that acquire continuous ECG and physiologic data.

J Electrocardiol

September 2024

Department of Physiological Nursing, University of California San Francisco School of Nursing, California, USA; Division of Cardiology, University of California San Francisco School of Medicine, California, USA. Electronic address:

Data capture systems that acquire continuous hospital-based electrocardiographic (ECG) and physiologic (vital signs) data can foster robust research (i.e., large sample sizes from consecutive patients).

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Importance: Posttraumatic stress disorder (PTSD) symptom reduction is linked with lower risk of incident type 2 diabetes (T2D), but little is known about the association between PTSD and comorbid T2D outcomes. Whether PTSD is a modifiable risk factor for adverse T2D outcomes is unknown.

Objective: To determine whether patients with PTSD who improved and no longer met diagnostic criteria for PTSD had a lower risk of adverse T2D outcomes compared with patients with persistent PTSD.

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Family support plays an important role in promoting resilience and health among transgender and/or nonbinary youth (TNBY), but family members often experience barriers to supporting their TNBY, including minority-adjacent stress stemming from exposure to structural stigma and antitransgender legislation. TNBY and their families need effective family-level interventions developed using community-based participatory research (CBPR), which integrates community members (e.g.

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Importance: Decades-old data indicate that people imprisoned in the US have poor access to health care despite their constitutional right to care. Most prisons impose co-payments for at least some medical visits. No recent national studies have assessed access to care or whether co-pays are associated with worse access.

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