A phase I trial of paclitaxel and etoposide for metastatic or recurrent malignancies.

Etoposide and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) each exhibit substantial activity against a variety of solid tumors. Etoposide promotes accumulation of cells in late S phase and in G2. Paclitaxel causes cell arrest in G2 and M.

Tyrosine phosphorylation is required for up-regulation of the HOX-11 (TCL-3) homeobox proto-oncogene in T cells.

HOX-11 (TCL-3) is a homeobox proto-oncogene isolated from the breakpoint region of the t(10;14) chromosomal translocation associated with pediatric T-cell acute leukemia. To better understand the transcriptional regulation of the HOX-11 gene in response to extracellular signals, the levels of HOX-11 RNA were examined in normal and leukemic human T cells upon phytohemagglutinin and hematopoietic growth factor stimulation. While individual hematopoietic growth factors tested did not show any effect on HOX-11 gene expression, a drastic increase in HOX-11 RNA was observed under the induction of phytohemagglutinin.