2 results match your criteria: "University of California and Rady Children's Hospital San Diego[Affiliation]"
Treatment of pediatric spasticity, including children with cerebral palsy, with Botox (onabotulinumtoxinA): Development, insights, and impact.
Medicine (Baltimore)
July 2023
Allergan/AbbVie, Irvine, CA, USA.
Spasticity is a velocity-dependent increase in muscle tone that has a negative effect on quality of life and hinders the ability of others to provide care. In children, most cases are caused by cerebral palsy. Traditionally, many children are treated with surgery, sometimes performed before their limbs had grown sufficiently to permit long-term success.
View Article and Find Full Text PDFTransforming growth factor-beta signaling pathway in patients with Kawasaki disease.
Circ Cardiovasc Genet
February 2011
University of California and Rady Children's Hospital San Diego, San Diego, CA, USA.
Background: Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which are important features of Kawasaki disease (KD). We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome.
Methods And Results: We investigated genetic variation in 15 genes belonging to the TGF-β pathway in a total of 771 KD subjects of mainly European descent from the United States, the United Kingdom, Australia, and the Netherlands.