2,609 results match your criteria: "University of California School of Medicine[Affiliation]"
Am Fam Physician
December 2024
Kaiser Permanente San Jose Medical Center, California.
Global Spine J
December 2024
Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS, USA.
Traditionally, the thermostability of a protein is defined by a melting temperature, at which half of the protein is unfolded. However, this definition cannot indicate the structural origin of a heat-induced unfolding pathway. Here, the thermoring structures were studied on the ATP-dependent heat-induced unfolding of the first nucleotide-binding domain from the human cystic fibrosis transmembrane conductance regulator.
View Article and Find Full Text PDFAnn Fam Med
November 2024
Department of Psychiatry and Behavioral Sciences, University of California School of Medicine, Los Angeles, California.
Purpose: The purpose of this study was to evaluate the effectiveness of collaborative trauma-informed care (CTIC) for treating depression in primary care in Chile.
Methods: From August 2021 through June 2023, 16 primary care teams in the Maule Region of Chile, were randomly assigned to either the CTIC or usual treatment (UT) group. At baseline, 3 months, and 6 months, 115 patients in the CTIC group, and 99 in the UT group, were blindly evaluated.
Addict Biol
November 2024
Department of Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
bioRxiv
October 2024
Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California-San Diego, La Jolla, CA 92093.
The mutants designated (cell lysis) cause cell lysis at elevated temperatures. The mutation, previously localized to an 80 kilobase region between and on the right arm of chromosome VII, has been used for mutation mapping and in recombination assays, but its genetic identity has remained unknown. Whole genome sequencing of mutant and wild-type strains revealed four missense mutations specific to the mutant strain in the - interval, three of these missense mutations affected essential genes.
View Article and Find Full Text PDFbioRxiv
October 2024
Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616.
Voltage-gated sodium (Na) channels are vital regulators of electrical activity in excitable cells, playing critical roles in generating and propagating action potentials. Given their importance in physiology, Na channels are key therapeutic targets for treating numerous conditions, yet developing subtype-selective drugs remains challenging due to the high sequence and structural conservation among Na family members. Recent advances in cryo-electron microscopy have resolved nearly all human Na channels, providing valuable insights into their structure and function.
View Article and Find Full Text PDFQual Life Res
October 2024
Travere Therapeutics, 3611 Valley Centre Drive, Suite 300, San Diego, CA, 92130, USA.
Purpose: This cross-sectional survey study quantified the humanistic burden of immunoglobulin A nephropathy (IgAN), in terms of physical and mental health-related quality of life (HRQoL) and work productivity, among adults with primary IgAN and their care-partners.
Methods: HRQoL was assessed (01/31/22 - 05/31/23) with validated tools including the KDQoL-36 (with SF-12), GAD-7 (anxiety), PHQ-9 (depression), and WPAI: SHP (work productivity). Participant characteristics and total/domain scores were summarized; selected outcomes were compared to an external, kidney disease-free cohort.
Global Spine J
October 2024
Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS, USA.
Int J Comput Assist Radiol Surg
October 2024
Mechanical and Materials Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Clin Dermatol
September 2024
Private Practice, Pembroke Pines, Florida, USA. Electronic address:
BMC Public Health
September 2024
Family and Community Health, University of Maryland School of Nursing, Baltimore, MD, USA.
Background: Given increased interest and investment in guaranteed income initiatives across North America, it is critical to understand the impact of guaranteed income on health, an understudied outcome. As part of Baltimore, Maryland's guaranteed income pilot, we conducted formative research to understand the influence of increased income on health and develop concrete recommendations for implementation and evaluation of the pilot.
Methods: We conducted semi-structured in-depth interviews with Baltimore community residents (n = 8) and community collaborators (n = 8), probing on familiarity with guaranteed income; effect of guaranteed income on overall health and specific health outcomes (e.
Arch Pathol Lab Med
September 2024
From The Department of Pathology, Stanford University Hospital, Stanford, California (Charville).
Global Spine J
September 2024
Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS, USA.
Study Design: Retrospective Cohort Study.
Objectives: Length of Stay (LOS) and resource utilization are of primary importance for hospital administration. This study aimed to understand the incremental effect of having a specific complication on LOS among ASD patients.
Acta Neuropathol Commun
September 2024
Department of Pathology, Neuropathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Neuroepithelial tumors with fusion of PLAGL1 or amplification of PLAGL1/PLAGL2 have recently been described often with ependymoma-like or embryonal histology respectively. To further evaluate emerging entities with PLAG-family genetic alterations, the histologic, molecular, clinical, and imaging features are described for 8 clinical cases encountered at St. Jude (EWSR1-PLAGL1 fusion n = 6; PLAGL1 amplification n = 1; PLAGL2 amplification n = 1).
View Article and Find Full Text PDFDermatol Surg
September 2024
Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.
Background And Objective: Botulinum toxin treatment is gaining popularity among men for cosmetic purposes driven by workplace competition and a desire for confidence and youthfulness. Because of the unique features of male facial anatomy, careful consideration is necessary during assessment and treatment execution.
Methods: The peer-reviewed literature on male facial anatomy in relation to neuromodulator treatment was analyzed with a particular emphasis on studies involving male subjects and the use of botulinum toxin type A.
Dermatol Surg
September 2024
Clinical Professor of Dermatology, University of California School of Medicine, San Francisco, California.
Oncologist
November 2024
New York University Langone Health, New York, NY, United States.
Background: Modulation of glucocorticoid receptor (GR) activity in tumor cells enhances chemotherapy efficacy. We evaluated the selective GR modulator relacorilant plus nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who had received at least 2 prior therapy lines.
Patients And Methods: In this open-label, single-arm, phase III study, patients received once-daily oral relacorilant (100 mg, titrated to 150 mg in 25 mg increments/cycle) and nab-paclitaxel (80 mg/m2) on days 1, 8, and 15 of 28-day cycles.
Physiology (Bethesda)
January 2025
Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, California, United States.
Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable cells and are critical pharmaceutical targets for treating many diseases including cardiac arrhythmia and neuropathic pain. Despite their significance, challenges such as achieving target selectivity persist in VGIC drug development. Recent progress in deep learning, particularly diffusion models, has enabled the computational design of protein binders for any clinically relevant protein based solely on its structure.
View Article and Find Full Text PDFJAMA Netw Open
August 2024
Department of Psychiatry and Behavioral Sciences, University of California School of Medicine, San Francisco.
Clin Exp Metastasis
August 2024
California Pacific Medical Center and Research Institute, University of California School of Medicine, San Francisco, USA.
Cancer cells within a population are heterogeneous due to genomic mutations or epigenetic changes. The immune response to cancer especially the T cell repertoire within the cancer microenvionment is important to the control and growth of cancer cells. When a cancer clone breaks through the surveillance of the immune system, it wins the battle to overcome the host's immune system.
View Article and Find Full Text PDFCancers (Basel)
August 2024
Center for Melanoma Research and Treatment, California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA.
Dermatitis
July 2024
From the Women's College Research Institute and Department of Medicine, Women's College Hospital, Toronto, Canada.
Clin Exp Metastasis
August 2024
Department of Surgery, Neurosurgery and Pediatrics, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is still under intense study. In this review article, we follow the journey of cancer cells metastasizing to the sentinel lymph nodes and beyond to the distant sites. We emphasize cancer heterogeneity and microenvironment as major determinants of cancer metastasis.
View Article and Find Full Text PDFYonsei Med J
July 2024
The Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Although advancements in medical treatments have been made, approximately half of patients with intestinal Crohn's disease (CD) require intestinal resections during their lifetime. It is well-known that the nutritional status of CD patients can impact postoperative morbidity. The objective of this study was to evaluate the clinical significance of prognostic nutritional index (PNI) in patients with intestinal CD who underwent primary bowel resection.
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