1 results match your criteria: "University of California Santa Cruz (A.R.G.[Affiliation]"
Arterioscler Thromb Vasc Biol
October 2016
From the Department of Pharmacology (J.Y., B.E.T., R.A., M.H.) and Department of Internal Medicine, Division of Cardiovascular Medicine (M.H.), University of Michigan, Ann Arbor; Cardeza Foundation for Hematological Research, Thomas Jefferson University, Philadelphia, PA (J.Y., B.E.T., R.A., P.F.-P., J.Y., M.H.); and Department of Chemistry and Biochemistry, University of California Santa Cruz (A.R.G., C.J.F., T.R.H.).
Objective: Dietary supplementation with polyunsaturated fatty acids has been widely used for primary and secondary prevention of cardiovascular disease in individuals at risk; however, the cardioprotective benefits of polyunsaturated fatty acids remain controversial because of lack of mechanistic and in vivo evidence. We present direct evidence that an omega-6 polyunsaturated fatty acid, dihomo-γ-linolenic acid (DGLA), exhibits in vivo cardioprotection through 12-lipoxygenase (12-LOX) oxidation of DGLA to its reduced oxidized lipid form, 12(S)-hydroxy-8Z,10E,14Z-eicosatrienoic acid (12(S)-HETrE), inhibiting platelet activation and thrombosis.
Approach And Results: DGLA inhibited ex vivo platelet aggregation and Rap1 activation in wild-type mice, but not in mice lacking 12-LOX expression (12-LOX(-/-)).