EGF and bFGF promote invasion that is modulated by PI3/Akt kinase and Erk in vestibular schwannoma.

Objectives: Vestibular schwannomas (VSs) are slow-growing benign tumors but, on rare occasion, can invade adjacent cranial nerves, causing significant morbidity, especially in association with neurofibromatosis 2 (NF2). We aimed to determine the role of the growth factors EGF, bFGF, and the hormone, Epo, in promoting such invasive behavior in VS, as well as their mechanisms of action.

Methods: Immunohistochemical staining showed expression of EGFR, bFGF, Epo, EpoR in archived VS tissue.

The prognostic implications of DSM-IV abuse criteria in drinking adolescents.

Background: The validity of the DSM-IV diagnostic criteria for alcohol abuse has been questioned, and additional issues have been raised regarding the performance of this label in adolescents. While future diagnostic manuals might alter the approach to abuse, it is worthwhile to evaluate the implications of the current definition that has been in place since 1994.

Methods: Six hundred and sixteen 12-19-year-old subjects (mean 16.

Anxiety sensitivity as a predictor of labor pain.

Psychosocial factors have been implicated in the pain experience during childbirth, which can have both short- and long-term consequences on the mother's health and her relationship with her infant. The present study evaluated important demographic, social, and psychological factors as predictors of multiple dimensions of labor pain among 35 mothers during childbirth. The results indicated that anxiety sensitivity (AS), as measured by the Anxiety Sensitivity Index, shared a significant relation with maximum pain during labor as well as sensory and affective components of pain as measured by the McGill Pain Questionnaire.

The emerging role of CD40 ligand in HIV infection.

CD40 ligand (also called CD40L, CD154, or TNFSF5) is a membrane protein expressed mainly by activated CD4+ T cells, which interacts with its receptor, CD40, on a variety of cells. The crucial importance of the CD40L-CD40 system for many immune responses has been extensively described. This review focuses on the multiple roles that this system may play in HIV infection.