1 results match your criteria: "University of California Los Angeles. ddowlat@toh.ca.[Affiliation]"
Hematoma Expansion Shift Analysis to Assess Acute Intracerebral Hemorrhage Treatments.
Neurology
August 2021
From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine, Neurology (V.Y., D.D.), and School of Epidemiology and Public Health (T.R., D.D.), University of Ottawa and Ottawa Hospital Research Institute (T.R., D.D.), Ontario; Department of Clinical Neurosciences, Radiology, and Community Health Sciences (B.K.M.), Cumming School of Medicine and the Hotchkiss Brain Institute (B.K.M.), University of Calgary, Alberta, Canada; Zeenat Qureshi Stroke Institute (A.L.Q.), University of Missouri, Columbia; and David Geffen School of Medicine Comprehensive Stroke Center (J.L.S.), University of California Los Angeles.
Objective: Hematoma expansion (HE) is commonly analyzed as a dichotomous outcome in intracerebral hemorrhage (ICH) trials. In this proof-of-concept study, we propose an HE shift analysis model as a method to improve the evaluation of candidate ICH therapies.
Methods: Using data from the Antihypertensive Treatment of Acute Cerebral Hemorrhage II (ATACH-2) trial, we performed HE shift analysis in response to intensive blood pressure lowering by generating polychotomous strata based on previously established HE definitions, percentile/absolute quartiles of hematoma volume change, and quartiles of 24-hour follow-up hematoma volumes.