1 results match your criteria: "University of California Los Angeles (N.U.M.[Affiliation]"
Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.
Arterioscler Thromb Vasc Biol
June 2016
From the Department of Molecular and Medical Pharmacology (N.U.M., S.T.R.) and Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles (N.U.M., V.G., S.H., A.W., M.N., A.M.F., S.T.R.).
Objective: We previously reported that hemopexin (Hx), a heme scavenger, is significantly increased and associated with proinflammatory high-density lipoprotein under atherogenic conditions. Although it is established that Hx together with macrophages plays a role in mitigating oxidative damage, the role of Hx in the development of atherosclerosis is unknown.
Approach And Results: We used Hx and apoE double-knockout mice (HxE(-/-)) to determine the role of Hx in the development of atherosclerosis.