4 results match your criteria: "University of California Irvine Susan and Henry Samueli College of Health Sciences[Affiliation]"
Ambient Air Pollution and COPD: The Multiethnic Cohort Study.
Ann Am Thorac Soc
January 2025
University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, California, United States.
Rationale: Globally, in 2019, chronic obstructive pulmonary disease (COPD) was the third leading cause of death. While tobacco smoking is the predominant risk factor, the role of long-term air pollution exposure in increasing risk of COPD remains unclear. Moreover, there are few studies that have been conducted in racial and ethnic minoritized and socioeconomically diverse populations, while accounting for smoking history and other known risk factors.
View Article and Find Full Text PDFBreathing Room: Industrial Zoning and Asthma Incidence Using School District Health Records in the City of Santa Ana, California.
Int J Environ Res Public Health
April 2022
Department of Pediatrics, University of California Irvine School of Medicine, Irvine, CA 92617, USA.
Background: Traffic and industrial emissions are associated with increased pediatric asthma morbidity. However, few studies have examined the influence of city industrial zoning on pediatric asthma outcomes among minoritized communities with limited access to air monitoring. Methods: In this cross-sectional analysis of 39,974 school-aged students in Santa Ana, CA, we investigated the effect of proximity to areas zoned for industrial use on pediatric asthma prevalence, physical fitness, school attendance, and standardized test scores.
View Article and Find Full Text PDFNRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis.
Trends Cancer
March 2022
Chao Family Comprehensive Cancer Center, Orange, CA 92868, USA; University of California Irvine Susan and Henry Samueli College of Health Sciences, University of California Irvine School of Medicine, Department of Medicine, Division of Hematology-Oncology, Orange, CA 92868, USA. Electronic address:
Neuregulins (NRGs) are a family of six related physiological ligands all containing a receptor-binding epidermal growth factor (EGF)-like domain that mediate their binding to cellular receptors. Neuregulin-1 (NRG1) is the main physiological ligand to HER3. NRG1 fusion (NRG1+) was first reported in a breast cancer cell line and NRG2 fusions have recently been identified in solid tumors.
View Article and Find Full Text PDFSARS-CoV-2 antibody seroprevalence among firefighters in Orange County, California.
Occup Environ Med
November 2021
Department of Environmental and Occupational Health, University of California Irvine Susan and Henry Samueli College of Health Sciences, Irvine, California, USA.
Objectives: We conducted serological SARS-CoV-2 antibody testing from October to November 2020 to estimate the SARS-CoV-2 seroprevalence among firefighters/paramedics in Orange County (OC), California.
Methods: OC firefighters employed at the time of the surveillance activity were invited to participate in a voluntary survey that collected demographic, occupational and previous COVID-19 testing data, and a SARS-CoV-2 immunoglobulin (Ig)G antibody blood test. We collected venous blood samples using mobile phlebotomy teams that travelled to individual fire stations, in coordination with an annual tuberculosis testing campaign for firefighters employed by OC Fire Authority (OCFA), and independently for firefighters employed by cities.