Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes.

Background Mitochondrial transplantation has been recently explored for treatment of very ill cardiac patients. However, little is known about the intracellular consequences of mitochondrial transplantation. This study aims to assess the bioenergetics consequences of mitochondrial transplantation into normal cardiomyocytes in the short and long term.

Expansion of Coccidioidomycosis Endemic Regions in the United States in Response to Climate Change.

Coccidioidomycosis (Valley fever) is a fungal disease endemic to the southwestern United States. Across this region, temperature and precipitation influence the extent of the endemic region and number of Valley fever cases. Climate projections for the western United States indicate that temperatures will increase and precipitation patterns will shift, which may alter disease dynamics.

A Framework for Global Multicategory and Multiscalar Drought Characterization Accounting for Snow Processes.

Drought indices do not always provide the most relevant information for water resources management as most of them neglect the role of snow in the land surface water balance. In this study, a physically based drought index, the Standardized Moisture Anomaly Index (SZI), was modified and improved by incorporating the effects of snow dynamics for drought characterization at multiple time scales. The new version of the SZI, called SZI, includes snow in both the water supply and demand in drought characterization by using the water-energy budgets from the Global Land Data Assimilation Systems product.

Natural Disasters Are Prejudiced Against Disadvantaged and Vulnerable Populations: The Lack of Publicly Available Health-Related Data Hinders Research at the Cusp of the Global Climate Crisis.

Natural disasters often affect the most vulnerable countries/communities around the world. However, within the same countries/communities, the impact of natural disasters is far greater on disadvantaged populations. We investigate how wildfires affect asthma prevalence in different populations across California.

Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery.

Background Impaired neurological function affects 85% to 90% of cardiac arrest (CA) survivors. Pulsatile blood flow may play an important role in neurological recovery after CA. Cerebral blood flow (CBF) pulsatility immediately, during, and after CA and resuscitation has not been investigated.

Manipulating nonadiabatic conical intersection dynamics by optical cavities.

Optical cavities hold great promise to manipulate and control the photochemistry of molecules. We demonstrate how molecular photochemical processes can be manipulated by strong light-matter coupling. For a molecule with an inherent conical intersection, optical cavities can induce significant changes in the nonadiabatic dynamics by either splitting the pristine conical intersections into two novel polaritonic conical intersections or by creating light-induced avoided crossings in the polaritonic surfaces.

Diet variability among insular populations of lizards reveals diverse strategies to face resource-limited environments.

Access to resources is a dynamic and multicausal process that determines the success and survival of a population. It is therefore often challenging to disentangle the factors affecting ecological traits like diet. Insular habitats provide a good opportunity to study how variation in diet originates, in particular in populations of mesopredators such as lizards.

Diet Quality and Cardiovascular Disease Risk in Postmenopausal Women With Type 2 Diabetes Mellitus: The Women's Health Initiative.

Background Dietary patterns are associated with cardiovascular disease (CVD) risk in the general population, but diet-CVD association in populations with diabetes mellitus is limited. Our objective was to examine the association between diet quality and CVD risk in a population with type 2 diabetes mellitus. Methods and Results We analyzed prospective data from 5809 women with prevalent type 2 diabetes mellitus at baseline from the Women's Health Initiative.

Scalable synthesis of gyroid-inspired freestanding three-dimensional graphene architectures.

Three-dimensional porous architectures of graphene are desirable for energy storage, catalysis, and sensing applications. Yet it has proven challenging to devise scalable methods capable of producing co-continuous architectures and well-defined, uniform pore and ligament sizes at length scales relevant to applications. This is further complicated by processing temperatures necessary for high quality graphene.

C-Free Carbon Is a Major Contributor to Cellular Biomass in Geochemically Distinct Groundwater of Shallow Sedimentary Bedrock Aquifers.

Despite the global significance of the subsurface biosphere, the degree to which it depends on surface organic carbon (OC) is still poorly understood. Here, we compare stable and radiogenic carbon isotope compositions of microbial phospholipid fatty acids (PLFAs) with those of in situ potential microbial C sources to assess the major C sources for subsurface microorganisms in biogeochemical distinct shallow aquifers (Critical Zone Exploratory, Thuringia Germany). Despite the presence of younger OC, the microbes assimilated C-free OC to varying degrees; ~31% in groundwater within the oxic zone, ~47% in an iron reduction zone, and ~70% in a sulfate reduction/anammox zone.

Soil Organic Matter Persistence as a Stochastic Process: Age and Transit Time Distributions of Carbon in Soils.

The question of why some types of organic matter are more persistent while others decompose quickly in soils has motivated a large amount of research in recent years. Persistence is commonly characterized as turnover or mean residence time of soil organic matter (SOM). However, turnover and residence times are ambiguous measures of persistence, because they could represent the concept of either age or transit time.

Statin Therapy Before Transition to End-Stage Renal Disease With Posttransition Outcomes.

Background Although studies have shown that statin therapy in patients with non-dialysis-dependent chronic kidney disease was associated with a lower risk of death, this was not observed in dialysis patients newly initiated on statins. It is unclear if statin therapy benefits administered during the predialysis period persist after transitioning to end-stage renal disease. Methods and Results In 47 720 veterans who transitioned to end-stage renal disease during 2007 to 2014, we examined the association of statin therapy use 1 year before transition with posttransition all-cause and cardiovascular mortality and hospitalization incidence rates over the first 12 months of follow-up.

Multiple infection of cells changes the dynamics of basic viral evolutionary processes.

The infection of cells by multiple copies of a given virus can impact viral evolution in a variety of ways, yet some of the most basic evolutionary dynamics remain underexplored. Using computational models, we investigate how infection multiplicity affects the fixation probability of mutants, the rate of mutant generation, and the timing of mutant invasion. An important insight from these models is that for neutral and disadvantageous phenotypes, rare mutants initially enjoy a fitness advantage in the presence of multiple infection of cells.

Climatic Responses to Future Trans-Arctic Shipping.

As global temperatures increase, sea ice loss will increasingly enable commercial shipping traffic to cross the Arctic Ocean, where the ships' gas and particulate emissions may have strong regional effects. Here we investigate impacts of shipping emissions on Arctic climate using a fully coupled Earth system model (CESM 1.2.

Soil Carbon Dynamics in Soybean Cropland and Forests in Mato Grosso, Brazil.

Climate and land use models predict that tropical deforestation and conversion to cropland will produce a large flux of soil carbon (C) to the atmosphere from accelerated decomposition of soil organic matter (SOM). However, the C flux from the deep tropical soils on which most intensive crop agriculture is now expanding remains poorly constrained. To quantify the effect of intensive agriculture on tropical soil C, we compared C stocks, radiocarbon, and stable C isotopes to 2 m depth from forests and soybean cropland created from former pasture in Mato Grosso, Brazil.

A Century of Stability of Avannarleq and Kujalleq Glaciers, West Greenland, Explained Using High-Resolution Airborne Gravity and Other Data.

The evolution of Greenland glaciers in a warming climate depends on their depth below sea level, flow speed, surface melt, and ocean-induced undercutting at the calving front. We present an innovative mapping of bed topography in the frontal regions of Sermeq Avannarleq and Kujalleq, two major glaciers flowing into the ice-choked Torssukatak Fjord, central west Greenland. The mapping combines a mass conservation algorithm inland, multibeam echo sounding data in the fjord, and high-resolution airborne gravity data at the ice-ocean transition where other approaches have traditionally failed.

Reproductive suppression, birth defects, and periviable birth.

We argue that reproductive suppression has clinical implications beyond its contribution to the burden of spontaneous abortion. We theorize that the incidence of births before the 28th week of gestation, which contribute disproportionately to infant morbidity and mortality, varies over time in part due to reproductive suppression in the form of selection in utero. We further theorize that the prevalence of structural birth defects among survivors to birth from conception cohorts gauges selection in utero.

Rainfall From Resolved Rather Than Parameterized Processes Better Represents the Present-Day and Climate Change Response of Moderate Rates in the Community Atmosphere Model.

Deficiencies in the parameterizations of convection used in global climate models often lead to a distorted representation of the simulated rainfall intensity distribution (i.e., too much rainfall from weak rain rates).

Global, Regional, and Megacity Trends in the Highest Temperature of the Year: Diagnostics and Evidence for Accelerating Trends.

Trends in short-lived high-temperature extremes record a different dimension of change than the extensively studied annual and seasonal mean daily temperatures. They also have important socioeconomic, environmental, and human health implications. Here, we present analysis of the highest temperature of the year for approximately 9000 stations globally, focusing on quantifying spatially explicit exceedance probabilities during the recent 50- and 30-year periods.

Coccidioidomycosis Dynamics in Relation to Climate in the Southwestern United States.

Valley fever is endemic to the southwestern United States. Humans contract this fungal disease by inhaling spores of spp. Changes in the environment can influence the abundance and dispersal of spp.

BedMachine v3: Complete Bed Topography and Ocean Bathymetry Mapping of Greenland From Multibeam Echo Sounding Combined With Mass Conservation.

Greenland's bed topography is a primary control on ice flow, grounding line migration, calving dynamics, and subglacial drainage. Moreover, fjord bathymetry regulates the penetration of warm Atlantic water (AW) that rapidly melts and undercuts Greenland's marine-terminating glaciers. Here we present a new compilation of Greenland bed topography that assimilates seafloor bathymetry and ice thickness data through a mass conservation approach.

Receptor uptake arrays for vitamin B, siderophores, and glycans shape bacterial communities.

Molecular variants of vitamin B, siderophores, and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe has three different receptors to take up variants of vitamin B and 88 receptors to take up various glycans.

β-Deuterium Isotope Effects on Firefly Luciferase Bioluminescence.

A 5,5- -luciferin was prepared to measure isotope effects on reactions of two intermediates in firefly bioluminescence: emission by oxyluciferin and elimination of a putative luciferyl adenylate hydroperoxide to dehydroluciferin. A negligible isotope effect on bioluminescence provides further support for the belief that the emitting species is the keto-phenolate of oxyluciferin and rules out its excited-state tautomerization, one potential contribution to a bioluminescence quantum yield less than unity. A small isotope effect on dehydroluciferin formation supports a single-electron-transfer mechanism for reaction of the luciferyl adenylate enolate with oxygen to form the hydroperoxide or dehydroluciferin.