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Distinct roles for AF-1 and -2 of ER-alpha in regulation of MMP-13 promoter activity.
Biochim Biophys Acta
March 2009
McCaig Institute for Bone and Joint Health, Faculty of Medicine, University of Calgary 3330 Hospital Dr. N.W. Calgary, Alberta, Canada T2N 4N1.
Previous studies have indicated that ER-alpha can influence the activity of the MMP-13 promoter. ER-alpha activity is mediated by two separate transcriptional activation domains (AF-1 and AF-2). The present study focused on analyzing the roles of these domains on the activation of the MMP-13 promoter.
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