1,194 results match your criteria: "University of British Columbia-Vancouver[Affiliation]"

Background: The role of evaluation evidence in guiding health systems strengthening (HSS) investments at the global-level remains contested. A lack of rigorous impact evaluations is viewed by some as an obstacle to scaling resources. However, others suggest that power dynamics and knowledge hierarchies continue to shape perceptions of rigor and acceptability in HSS evaluations.

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Objective: This study aims to explore a streamlined risk-adjusted cesarean section rate (RCSR) model and to compare its practical application effects with the traditional RCSR models.

Methods: Utilizing obstetric electronic health record (EHR) data from provincial multicenter hospitals, this study establishes a streamlined RCSR model alongside the traditional RCSR model and evaluates the efficacy of both models. Subsequently, the RCSRs of 56 hospitals within the province are calculated and ranked using both models.

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Multi-level insights into the immuno-oncology-microbiome axis: From biotechnology to novel therapies.

Imeta

October 2024

Department of Thoracic Surgery The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University Wuxi China.

Article Synopsis
  • * Advances in microbiome sequencing technologies are crucial for understanding how gut microbiota influence tumors and the interactions between host cells and microbes within tumors.
  • * Future advancements in biotechnology are expected to enhance cancer treatment strategies through microbial therapies and bioengineered microbes, diversifying current oncotherapy options.
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Background: While teamwork is essential to providing high-quality patient-centred care, challenges in interprofessional collaboration and decision-making in hospital settings are common, especially for patients with cancer. The purpose of this qualitative study was to identify emerging themes and potential challenges related to hospital discharge experiences among patients hospitalised for cancer who became frequent emergency department (ED) users postdischarge.

Methods: A cohort of patients with cancer discharged from an academic health centre in Montreal (Canada) between October 2014 and November 2016 was assembled.

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Antiphospholipid syndrome (APS), cryoglobulinemia, and monoclonal gammopathies are variably accompanied by thrombotic complications. We describe a patient with recurrent skin microvascular thrombosis, APS, cryoglobulinemia, marginal zone lymphoma, and IgMκ monoclonal gammopathy, responsive to chemoimmunotherapy. The cryoglobulin fraction contained the IgMκ paraprotein, while antiphospholipid antibodies (aPL) were predominantly in the cryosupernatant.

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  • * Research indicates that bulk redox occurs in LiNiO through Ni-O rehybridization without involving trapped molecular oxygen, which is linked to surface degradation.
  • * Degradation is characterized by oxygen removal upon discharge and persistent nickel reduction, suggesting the need for effective surface stabilization to improve LiNiO performance.
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  • A study compared the effectiveness of IV tenecteplase and IV alteplase in patients undergoing thrombectomy for acute ischemic stroke, using data from the AcT trial.
  • It analyzed the outcomes of different endovascular thrombectomy strategies (stent retriever vs. aspiration) and how they interacted with the type of thrombolysis used.
  • Results indicated that while there was no overall difference in efficacy, tenecteplase was associated with better outcomes when paired with aspiration as the first-line strategy.
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Freshwater jellyfish (= limnic medusa-budding hydrozoans, FWJ) are a small group of cnidarians found on all continents except Antarctica in temperate to tropical latitudes. Members of this group belong primarily to three genera: , , and . While and are typically restricted to the islands of Japan, Africa, and the Indian subcontinent, one species or potential species complex, , became globally invasive.

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  • Neighborhood-level income is linked to cardiovascular events, with the relationship differing between immigrants and long-term residents.
  • A study of 5.2 million urban-dwelling individuals in Ontario found that the impact of income on cardiovascular events was less pronounced in immigrants than in long-term residents.
  • Understanding how immigration status affects health outcomes can inform targeted prevention strategies for those living in low-income neighborhoods.
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  • The Canadian Open Parkinson Network (C-OPN) aims to enhance collaboration between study participants, clinicians, and researchers to boost Parkinson's disease research across ten universities and research centers in Canada.
  • The C-OPN database collects a variety of data, including demographic information, treatment approaches, and biological samples, which are accessible for multi-center studies via web-based systems like REDCap.
  • By November 2023, the C-OPN had enrolled 1,505 participants, with a focus on environmental and symptom analysis, serving as a platform for innovative research and collaboration among scientists in Canada.
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Assisted migration provides a potential solution to mitigate the increasing risks of forest maladaptation under climate change. Western larch ( Nutt.) is a deciduous conifer species undergoing assisted migration beyond its natural range in British Columbia into areas that have become suitable based on climatic niche modelling.

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Pulmonary arterial hypertension affects females more frequently than males, and there are known sex-related differences in the lungs. However, normal sex-related differences in pulmonary vascular structure remain incompletely described. We aimed to contrast computed tomography-derived pulmonary vascular volume and its distribution within the lungs of healthy adult females and males.

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Developmental and epileptic encephalopathies after successful treatment of pediatric ALL: A case series and review of literature.

Epileptic Disord

December 2024

Department of Pediatrics, Division of Neurology, Faculty of Medicine, BC Children's Hospital, University of British Columbia Vancouver, Vancouver, British Columbia, Canada.

Article Synopsis
  • Successful treatment of acute lymphoblastic leukemia (ALL) involves multiagent chemotherapy and CNS prophylaxis, but a minority of patients can develop drug resistant epilepsy (DRE) and epileptic encephalopathies (EE) like Lennox-Gastaut syndrome (LGS).
  • A study of four ALL remission patients revealed that all patients faced significant challenges, including DRE, moderate intellectual disability, and neuropsychiatric issues, with symptoms often beginning around the age of 5.6 years.
  • The findings suggest that younger age at diagnosis (under 3 years) may increase the risk of developing DRE and EEs, while common palliative treatments like the ketogenic diet and corpus callosotomy show limited effectiveness.
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Background: Patients with atrial fibrillation are frequently nonadherent to oral anticoagulants (OACs) prescribed for stroke and systemic embolism (SSE) prevention. We quantified the relationship between OAC adherence and atrial fibrillation clinical outcomes using methods not previously applied to this problem.

Methods And Results: Retrospective observational cohort study of incident cases of atrial fibrillation from population-based administrative data over 23 years.

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species can function as plant pathogens, saprobes or endophytes on a wide variety of plant hosts and are considered amongst the ten most significant genera of plant pathogens globally. China contributes almost half the walnut production in the world. However, species occurring on walnut remain largely unresolved in China.

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Background And Aims: Endocan is a marker of endothelial damage. Data regarding the association of this proteoglycan and acute respiratory distress syndrome (ARDS) is discrepant. Hence, this study sought to investigate the possible correlation between serum/plasma endocan concentration and ARDS.

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Background: Abortions are common and associated with procedural pain. We aimed to evaluate benefits and harms of local anaesthesia given for pain control during surgical abortion at less than 14 weeks' gestation.

Methods: We searched a systematic review on local anaesthesia for pain control for surgical abortion at less than 14 weeks' gestation using uterine aspiration.

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With the pronounced ongoing growth of global youth sports, opportunities for and participation of youth athletes on the world sports stage, including the Olympic Games, are expected to escalate. Yet, adolescence is a vulnerable period of development and inherently dynamic, with non-linear and asynchronous progression of physical, physiological, psychological and social attributes. These non-concurrent changes within and between individuals are accompanied by irregular and unpredictable threats and impediments.

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The search methods used in systematic reviews provide the foundation for establishing the body of literature from which conclusions are drawn and recommendations made. Searches should aim to be comprehensive and reporting of search methods should be transparent and reproducible. Campbell Collaboration systematic reviews strive to adhere to the best methodological guidance available for this type of searching.

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Introduction: Health-focused communities can promote physical activity for children by providing them with safe and supportive environments to move. Across the COVID-19 pandemic many community spaces and services were closed due to public health restrictions. During the pandemic, Atlantic Canada uniquely implemented an agreement between four provinces to restrict travel and reduce the spread of the virus.

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Multi-resonance thermally activated delayed fluorescence (MR-TADF) materials are of interest for light-emitting applications due to their narrow emission bandwidths and high photoluminescence quantum yields. Whilst there have been numerous examples of multi-resonance molecules exhibiting efficient TADF, the photophysics and mechanism of TADF in multi-resonance emitters have not been investigated to the same extent as the more conventional spatially separated donor-acceptor TADF materials, limiting the development of MR-TADF devices. Here we study the photophysics of a multi-resonance TADF material, OQAO(mes), using transient absorption spectroscopy to spectrally resolve the triplet population(s).

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Introduction: Practical social media recommendations are needed to facilitate greater engagement in dementia prevention research. Alongside relevant experts, our aim was to develop a set of consensus recommendations that reflect the values and priorities of prospective participants to guide social media use.

Methods: We conducted a three-round, modified Delphi consisting of three online surveys and three conferences calls.

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Background: Research indicates that mechanics differ between athletes with and without upper extremity pain; however, it is unclear which modifiable risk factors exist for throwing-related pain in softball athletes.

Purpose: To determine whether sport specialization, throwing, practice, and strength and conditioning training volumes vary between youth softball athletes with and without upper extremity pain. It was hypothesized that youth softball athletes with upper extremity pain would participate in softball year-round and have greater throwing, practice, and strength and conditioning volumes compared with those without pain.

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In recent years, the 'kirigami' technique has gained significant attention for creating meta-structures and meta-materials with exceptional characteristics, such as unprecedented stretchability. These properties, not typically inherent in the original materials or structures, present new opportunities for applications in stretchable and wearable electronics. However, despite its scientific and practical significance, the application of kirigami patterning on a monolayer of tungsten disulfide (WS), an emerging two-dimensional (2D) material with exceptional mechanical, electronic, and optical properties, has remained unexplored.

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