3 results match your criteria: "University of British Columbia at St. Paul's Hospital[Affiliation]"
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease.
N Engl J Med
September 2019
From the Respiratory Institute, Hospital Clinic, Institut d'Investigació Agustí Pi i Sunyer, and the University of Barcelona, Barcelona; and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid (A.A.); and the Center for Heart and Lung Innovation, University of British Columbia at St. Paul's Hospital, Vancouver, Canada (J.C.H.).
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.
EBioMedicine
November 2014
Centre for Microbial Diseases and Immunity Research, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada ; Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom.
Background: Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeated exposure can also induce a suppressive effect known as endotoxin tolerance or cellular reprogramming. It has been proposed that endotoxin tolerance might be associated with the immunosuppressive state that was primarily observed during late-stage sepsis.
View Article and Find Full Text PDFA sum greater than its parts.
Eur Respir J
December 2014
Centre for Heart Lung Innovation, University of British Columbia at St Paul's Hospital, Vancouver, BC, Canada Division of Respirology, University of British Columbia Dept of Medicine at St. Paul's Hospital, Vancouver, BC, Canada