7 results match your criteria: "University of British Columbia Southern Medical Program[Affiliation]"
Feasibility of Simon 2-Stage Futility Trials in Early Parkinson Disease: Analysis of the PRECEPT and DATATOP Trial Datasets.
Neurology
January 2025
From the Department of Clinical Neurosciences (M.W.K., J.R.S.), University of Calgary, Alberta; Division of Neurology (L.V.K.), Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario; Department of Medicine (D.W.), University of British Columbia Southern Medical Program, Kelowna; Division of Neurology (T.A.M., M.G.S.), Department of Medicine, University of Ottawa, The Ottawa Hospital Ottawa, Ontario, Canada; Department of Neurology (J.M.), Rijnstate Hospital, Arnhem; Department of Neurology (E.M.M.S., B.U.), MS Center Amsterdam, Amsterdam University Medical Centers, the Netherlands; Section on Statistical Planning and Analysis (A.S.), Department of Neurology, UT Southwestern Medical Center, Dallas; and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Background And Objectives: Disease-modifying treatments (DMTs) are a major unmet need in Parkinson disease (PD). To date, trials investigating DMT candidates in PD most often used a randomized controlled trial (RCT) design. Unfortunately, RCTs to date have not led to a breakthrough, in part because of the large sample sizes and length of follow-up required.
View Article and Find Full Text PDFFalse-negative sentinel lymph node biopsy for melanoma: a single-surgeon experience.
Can J Surg
September 2024
From the Department of Surgical Oncology, BC Cancer-Sindi Ahluwalia Hawkins Centre, Kelowna, B.C. (Downey, Baliski); the Cancer Surveillance and Outcomes, BC Cancer, Vancouver, B.C. (DeVries); the Department of Pathology, Kelowna General Hospital, Kelowna, B.C. (Lano); the University of British Columbia Southern Medical Program, Kelowna, B.C. (Baliski)
Background: The status of the regional lymph node basin is of prognostic importance in patients with melanoma, making the performance of sentinel lymph node biopsies (SLNBs) a key component of patient care management, particularly with the advent of immunotherapy for adjuvant treatment. The primary goal of our study was to assess the false-negative rate of SLNBs among patients with melanoma.
Methods: We conducted a retrospective review of patients with melanoma undergoing SLNB by a single surgeon between Jan.
A review of the role for pelvic floor physiotherapy in postmenopausal women with urinary incontinence.
Post Reprod Health
December 2024
Department of Medicine, University of British Columbia Southern Medical Program, Kelowna, BC, Canada.
Urinary incontinence is a prevalent condition affecting women. Pelvic floor physiotherapy is a specialized field of physiotherapy dedicated to assessing and treating pelvic floor muscles. This therapy has demonstrated benefits in addressing stress urinary incontinence in premenopausal women, with numerous studies supporting its efficacy in this population.
View Article and Find Full Text PDFGenetic testing for amyotrophic lateral sclerosis in Canada - an assessment of current practices.
Amyotroph Lateral Scler Frontotemporal Degener
May 2022
Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Article Synopsis
- A study was conducted to assess genetic testing practices at ALS clinics across Canada, using surveys and interviews with clinicians from 27 clinics.
- Results showed that 93% of clinics regularly test for familial ALS, but only 33% do so for sporadic ALS, highlighting significant barriers such as treatment impact perception, approval challenges, and inadequate genetic counseling access.
- Findings indicate that genetic testing access varies widely, with an average wait time of 10 months to see a genetic counselor, and calls for improved testing practices to ensure equitable healthcare delivery for ALS patients.
Performance of models predicting residual lymph node disease in melanoma patients following sentinel lymph node biopsy.
Am J Surg
May 2020
BC Cancer-Sindi Ahluwalia Hawkins Centre, Dept. of Surgical Oncology, 399 Royal Ave, Kelowna, BC, V1Y 5L3, Canada. Electronic address:
Background: Among melanoma patients with a tumor-positive sentinel node biopsy (SNB), approximately 20% harbor disease in non-sentinel nodes (nSN), as determined by a completion lymph node dissection (CLND). CLND lacks a survival benefit and has high morbidity. This study assesses predictive factors for nSN metastasis and validates five models predicting nSN metastasis.
View Article and Find Full Text PDFObjective: This study was conducted to analyse data from emergency ophthalmology referrals after-hours from different hospitals to identify the most common pathologies and compare accuracy of diagnoses. The primary objective was to identify common presenting entities and common causes of misdiagnosis in the emergency department to help guide education initiatives.
Design: This was a retrospective chart review that looked at consults occurring between September 1, 2015, and October 21, 2016.
Use of intravenous immune globulin in the ICU: a retrospective review of prescribing practices and patient outcomes.
Transfus Med
December 2010
Department of Medicine, Kelowna General Hospital, University of British Columbia Southern Medical Program, Kelowna, British Columbia, Canada.
Rationale: Intravenous immune globulin (IVIG) is a pooled human blood product. Much of IVIG use in Canada is prescribed for 'unlabelled' or 'off-label' indications. Due to costs, risk of use and limited supply, knowledge about the use of IVIG is important.
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