120,990 results match your criteria: "University of British Columbia; mtheret@brc.ubc.ca.[Affiliation]"
Drug Alcohol Depend
January 2025
British Columbia Centre on Substance Use, 1045 Howe St Suite 400, Vancouver, British Columbia V6Z 2A9, Canada; Interdepartmental Division of Addiction Medicine, St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6.
Background: People exposed to fentanyl may report that the dose of methadone in the commonly accepted therapeutic range feels too low. We examined self-reported methadone dose adequacy.
Methods: We conducted a retrospective cohort study of individuals prescribed methadone at a dose of at least 60mg daily using data from three community-recruited prospective cohort studies of people who use drugs in Vancouver, Canada from December 2016 through March 2020.
Dermatitis
January 2025
Arcutis Biotherapeutics, Inc., Westlake Village, CA, USA.
Safety and efficacy of roflumilast cream 0.15% for atopic dermatitis (AD) were demonstrated in two 4-week phase 3 trials. Evaluate long-term safety, tolerability, and efficacy of roflumilast cream 0.
View Article and Find Full Text PDFMycopathologia
January 2025
Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.
Epidemiological studies combining taxonomic and clinical data have been limited globally, particularly Guiyang, the most under-developed economic provincial capital city in southwestern China. A retrospective analysis was performed of dermatophyte epidemiology involving all culture-positive cases received between May 2017 and May 2023 at the Affiliated Hospital of Guizhou Medical University. Phylogenetic analysis was conducted on 391 dermatophyte isolates collected from patients using the rDNA internal transcribed spacer sequences.
View Article and Find Full Text PDFSupport Care Cancer
January 2025
Department of Dentistry and Oral Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
Purpose: This systematic review aimed to assess the updated literature for the prevention of salivary gland hypofunction and xerostomia induced by non-surgical cancer therapies.
Methods: Electronic databases of MEDLINE/PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials (RCT) that investigated interventions to prevent salivary gland hypofunction and/or xerostomia. Literature search began from the 2010 systematic review publications from the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) up to February 2024.
Elife
January 2025
Department of Psychology, Queens University, Kingston, Canada.
Movie-watching is a central aspect of our lives and an important paradigm for understanding the brain mechanisms behind cognition as it occurs in daily life. Contemporary views of ongoing thought argue that the ability to make sense of events in the 'here and now' depend on the neural processing of incoming sensory information by auditory and visual cortex, which are kept in check by systems in association cortex. However, we currently lack an understanding of how patterns of ongoing thoughts map onto the different brain systems when we watch a film, partly because methods of sampling experience disrupt the dynamics of brain activity and the experience of movie-watching.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Innovation in Dementia and Aging (IDEA) Lab, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
: Canada's long-term care (LTC) sector is struggling with a significant staffing crisis related to shortages, high-turnover rate, and challenging working conditions. The COVID-19 pandemic exacerbated these issues and emphasized the need for improved mental health support for LTC staff. Understanding and addressing the wellbeing of staff is important for ensuring quality of care and promoting a positive work environment for a healthy workforce.
View Article and Find Full Text PDFJ Bone Miner Res
January 2025
Radius Health Inc, Boston, MA, United States.
Early increases in bone turnover markers (BTMs) in response to anabolic therapy correlate with 18-month bone mineral density (BMD) increases in postmenopausal women with osteoporosis; however, this relationship has not been assessed in men. In this analysis, the correlation between changes from baseline in fasting intact serum procollagen type I N propeptide (PINP) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) at 1, 3, 6, and 12 months and percent increase from baseline in BMD at 12 months in men from the randomized phase 3 ATOM study (NCT03512262) were evaluated using Pearson's correlation coefficients. The uncoupling index (UI), a measure of the balance between markers of bone formation (PINP) and bone resorption (CTX), with positive UI favoring bone formation, was calculated.
View Article and Find Full Text PDFJ Glob Health
January 2025
Medical-surgical Nursing Department, Faculty of Nursing, Cairo University, Cairo, Egypt.
Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.
Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.
Neurooncol Adv
November 2024
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, USA.
Background: Alterations in cellular metabolism affect cancer survival and can manifest in metrics of body composition. We investigated the effects of various body composition metrics on survival in patients with glioblastoma (GBM).
Methods: We retrospectively analyzed patients who had an abdominal and pelvic computed tomography (CT) scan performed within 1 month of diagnosis of GBM (178 participants, 102 males, 76 females, median age: 62.
Ann Thorac Surg Short Rep
December 2024
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine and the Texas Heart Institute, Houston, Texas.
Ann Thorac Surg Short Rep
September 2024
Division of Cardiac Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
Rosai-Dorfman disease (RDD) is a nonmalignant disease of histiocyte proliferation. RDD usually presents with painless cervical lymphadenopathy, although extranodal involvement can occur. Cardiac involvement was reported in <0.
View Article and Find Full Text PDFAnn Behav Med
January 2025
Wroclaw Faculty of Psychology, SWPS University, Ostrowskiego 30b5, 53-238 Wroclaw, Poland.
Background: The close relationship processes and health model and the dyadic health influence model posit that relationship beliefs (eg, relationship satisfaction) and influence strategies (eg, provision and receipt of positive and negative social control) mediate health behavior change. However, evidence for such mediation in parent-child dyads is limited.
Purpose: Two complementary mediation hypotheses were tested: (1) social control forms indirect relationships with sedentary behavior (SB), via relationship satisfaction acting as a mediator; and (2) relationship satisfaction forms indirect relationships with SB, with social control operating as a mediator.
Clin Infect Dis
January 2025
Provincial TB Services, BC Centre for Disease Control, Vancouver, BC.
Background: There is growing interest in using high-dose rifampin for tuberculosis treatment. Recent studies suggest that triple-dose rifampin (TDR; ≥30 mg/kg/day) may be unsafe. We updated a systematic review to investigate the safety and efficacy of TDR.
View Article and Find Full Text PDFSci Rep
January 2025
Wildlife Institute of India, Dehradun, 248001, Uttarakhand, India.
Intra-specific interactions among top carnivores are among the most intriguing behavioural aspects and essential components of population dynamics. Static interactions pertain to space use, while dynamic interactions involve spatio-temporal patterns influenced by social structure, distribution, mate selection, and density. Previous studies have focused on static interactions, successfully estimating spatial overlap but leading to a knowledge gap of dynamic interaction to be able to compute attraction and avoidance on similar spatio-temporal scales.
View Article and Find Full Text PDFNat Commun
January 2025
University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing 'free' glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1).
View Article and Find Full Text PDFBMJ Open
January 2025
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia
Objective: To evaluate the relationship between infarct pattern, inferred stroke mechanism and risk of recurrence in patients with ischaemic stroke. The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.
Design: We conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.
Eur Respir J
January 2025
Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Physiol Rep
January 2025
Centre for Heart Lung Innovation, The University of British Columbia (UBC) and St. Paul's Hospital (SPH), Vancouver, British Columbia, Canada.
This study investigated sex differences in the development of pulmonary edema and exercise-induced arterial hypoxemia (EIAH) in well-trained endurance athletes during near-maximal exercise in a real-world setting. Twenty participants (10M vs. 10F; V̇Opeak: 69.
View Article and Find Full Text PDFInorg Chem
January 2025
Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Pendant organic chromophores have been used to improve the photocatalytic performance of many metal-based photosensitizers, particularly in first-row metals, by increasing π conjugation in ligands and lowering the energy of the photoactive absorption band. Using a combination of spectroscopic studies and computational modeling, we rationalize the excited state dynamics of a Co(III) complex containing pendant pyrene moieties, , where = 1,1'-(4-(pyren-1-yl)pyridine-2,6-diyl)bis(3-methyl-1-imidazol-3-ium). displays higher visible absorptivity, and blue luminescence from pyrene singlet excited states compared with [ = 1,1'-(pyridine-2,6-diyl)bis(3-methyl-1-imidazol-3-ium)] in which the pyrene moiety is absent.
View Article and Find Full Text PDFBiochim Biophys Acta Biomembr
January 2025
Land and Food Systems, University of British Columbia, Vancouver, Canada; Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada. Electronic address:
The Solanum tuberosum (common potato) plant specific insert (StPSI) is an antimicrobial protein domain that exhibits membrane-disrupting and membrane-fusing activity upon dimerization at acidic pH, activity proposed to involve electrostatic attraction and membrane anchoring mediated by specific positively-charged and conserved tryptophan residues, respectively. This study is the first to employ an in silico mutagenesis approach to clarify the structure-function relationship of a plant specific insert (PSI), where ten rationally-mutated StPSI variants were investigated using all-atom and coarse-grained molecular dynamics. The tryptophan (W) residue at position 18 (W18) of wild-type StPSI was predicted to confer structural flexibility to the dimer and mediate a partial separation of the assembled monomers upon bilayer contact, while residues including W77 and the lysine (K) residue at position 83 (K83) were predicted to stabilize secondary structure and influence association with the model membrane.
View Article and Find Full Text PDFChest
January 2025
Department of Medicine, University of British Columbia. Electronic address:
Topic Importance: Accurate assessment of a patient's volume status is crucial in many conditions, informing decisions on fluid prescribing, vasoactive agents, and decongestive therapies. Determining a patient's volume status is challenging, due to limitations in examination and investigations and the complexities of fluid homeostasis in disease states. Point-of-care ultrasound (POCUS) is useful in assessing hemodynamic parameters related to volume status, fluid responsiveness, and fluid tolerance.
View Article and Find Full Text PDFIntensive Crit Care Nurs
January 2025
School of Audiology and Speech Sciences, University of British Columbia, Vancouver, BC, Canada; Department of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada.
Early Hum Dev
January 2025
Department of Pediatrics, Division of Neonatology, The Hospital for Sick Children and the University of Toronto, Ontario, Canada. Electronic address:
Objectives: To build an early, prognostic model for adverse outcome in infants with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) based on brain magnetic resonance images (MRI), electrophysiological tests and clinical assessments were performed during the first 5 days of life.
Methods: Retrospective study of 182 neonates with HIE and managed with TH. The predominant pattern of HIE brain injury on MRI performed following cooling was scored by neuroradiologists.
Gait Posture
December 2024
School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada. Electronic address:
Background: To maintain standing balance, vestibular cues are processed and integrated with other sensorimotor signals to produce appropriate motor adjustments. Whole-body vestibular-driven postural responses are context-dependent and transformed based upon head and foot posture. Previous reports indicate the importance of intrinsic foot muscles during standing, but it is unclear how vestibular-driven responses of these muscles are modulated by alterations in stability and head posture.
View Article and Find Full Text PDFMed Sci Sports Exerc
January 2025
School of Health and Exercise Sciences, University of British Columbia-Okanagan Campus, Kelowna, BC, CANADA.
Background : The acute effects of high-intensity interval training (HIIT) on blood pressure (BP) may depend on the exercise protocol performed. Purpose: To compare the acute effect of high and low-volume HIIT on post-exercise and ambulatory BP in untrained older females diagnosed with both type 2 diabetes (T2D) and hypertension (HTN). Methods: Fifteen females (69 [65 ─ 74] years) completed a crossover study with three experimental conditions: 1) REST (35 min in sitting position); 2) HIIT10 (10 × 1 min at 90% heart rate max [HRmax]), and 3) HIIT4 (4 × 4 min at 90% HRmax).
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