Mpox in the news: social representations, identity, stigma and coping.

In May 2022, when the COVID-19 pandemic began to recede from public view, another infectious disease surprised the world-mpox (formerly monkeypox). It appeared to disproportionately affect gay, bisexual and other men who have sex with men (GBMSM). Using qualitative thematic analysis and social representations theory, we analysed a corpus of 91 items from a variety of news outlets that included GBMSM community members' personal accounts of living through an mpox outbreak.

Flow synthesis and multidimensional parameter screening enables exploration and optimization of copper oxide nanoparticle synthesis.

Copper-based nanoparticles (NPs) are highly valued for their wide-ranging applications, with particular significance in CO reduction. However current synthesis methods encounter challenges in scalability, batch-to-batch variation, and high energy costs. In this work, we describe a novel continuous flow synthesis approach performed at room temperature to help address these issues, producing spherical, colloidally stable copper(ii) oxide (CuO) NPs.

Large-scale research infrastructure projects: A conceptual review for science policy and management.

This article reviews 'large-scale research infrastructures' work and other relevant literature from the science policy and management domains. Through a systematic literature review, the study identifies that there are no firm inclusion or exclusion criteria for a large-scale research infrastructure. The findings identify the need for filling this knowledge gap to support future analyses for large-scale research infrastructures to help scientists and science policymakers understand, plan, and evaluate their own work.

IFOMPT's Educational Standards and International Monitoring: A member survey and review.

Background: The International Federation of Manual and Musculoskeletal Physical Therapists (IFOMPT) membership requires accreditation of countries postgraduate musculoskeletal physiotherapy programmes to meet IFOMPT's Educational Standards through International Monitoring. The Educational Standards and International Monitoring are both being reviewed.

Objectives: To seek insight and feedback from IFOMPT's membership on the Educational Standards and International Monitoring to inform the current review.

How can a 4-day working week increase wellbeing at no cost to performance?

The 4-day working week is gaining interest, with international trials reporting enhanced staff wellbeing and performance, despite spending less time on the job. Here, we argue that improved performance on a 4-day working week arises through two psychological mechanisms of recovery and motivation: because better rested, better motivated brains, create better work.

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

This Letter reports a search for charge-parity (CP) symmetry violating nonstandard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from ν_{μ}(ν[over ¯]_{μ})→ν_{μ}(ν[over ¯]_{μ}) and ν_{μ}(ν[over ¯]_{μ})→ν_{e}(ν[over ¯]_{e}) oscillation channels are used to measure the effect of the NSI parameters ϵ_{eμ} and ϵ_{eτ}. With 90% CL the magnitudes of the NSI couplings are constrained to be |ϵ_{eμ}|≲0.

Sunscreens: A narrative review.

Sunscreens are topical formulations incorporating filters that protect our skin against ultraviolet radiation (UVR) emitted by the sun. Sunscreen use has been increasingly encouraged to protect against sunburn, skin cancer and photoaging that can occur because of prolonged and cumulative sun exposure. However, sunscreens and their constituent UVR filters have been purported to be problematic themselves.

The impact of interventions for depression on self-perceptions in young people: A systematic review & meta-analysis.

Negative self-perceptions are implicated in the development and maintenance of depression in young people, but little is known about their receptiveness to change in response to treatment. This paper reports on a pre-registered meta-analysis examining the extent to which treatments for depression in young people aged 11-24 result in changes to self-perceptions. Controlled treatment trials examining outcomes related to self-perceptions were synthesised (k = 20, N = 2041), finding small reductions in both symptoms of depression (g = -0.

Narrative Preparedness: Policy-Makers Must Engage With People's Values and Experiences to Ensure Effective Implementation of Interventions in Health Emergencies Comment on "Health Preparedness and Narrative Rationality: A Call for Narrative Preparedness".

Engebretsen and Baker's conceptual paper "" advocates for the adoption of narrative preparedness in addition to health preparedness, emphasising the importance of engaging with people's stories and values during health emergencies. This ensures that policy-makers and health authorities gain the trust of communities as there is evidence this leads to improved outcomes. Their key argument is that science cannot be used effectively in policy unless it makes sense to people and is presented in a way that resonates with their values.

The therapeutic potential of red beetroot ( L.) intake on muscle atrophy in immobilized mouse skeletal muscles.

Skeletal muscle atrophy is the reduction in muscle mass and function caused by an imbalance in protein synthesis and degradation. Inflammation has been shown to accelerate protein degradation during periods of muscle inactivity. We investigated the potential therapeutic effects of beetroot extract (BRE) in reducing inflammation and oxidative stress to prevent muscular atrophy after a short period of immobilization.

Fibroblast growth factor receptor 1 gene (FGFR1) amplification in non-small cell lung cancer (NSCLC) by real-time PCR.

Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients. The current study aimed to evaluate the prevalence of FGFR1 gene amplification and its association with clinical and demographic data in a group of NSCLC patients.

CLAMity: Mixtures of agricultural pesticides as multiple stressors in a bivalve species.

Pesticides play a vital role in ensuring global food security amid a growing global population; however, their movement away from application sites can pose significant risks to the health of non-target species. Pollution of freshwater is a key contributor to the high extinction rates of freshwater species, which often face exposure to a complex "cocktail" of pollutants simultaneously. A better understanding of pesticide interactions will enable more targeted policies and land management practices to mitigate environmental damage while ensuring food security.

The role of the FKBP51-Hsp90 complex in Alzheimer's disease: An emerging new drug target.

With increasing age comes the inevitable decline in proteostasis, where chaperone and co-chaperone activity becomes imbalanced. These changes lead to global disturbances and pathogenic rewiring of the chaperone system into epichaperones consisting of protein networks that are ultimately dysfunctional. Such imbalances in proteostasis may favor mechanisms that can lead to neurological diseases, such as Alzheimer's disease (AD).

Fostering healthy cognitive ageing in people living with HIV.

Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces.

Investigating pre-registration podiatry students approaches to identifying dermatology conditions in different skin tones: A mixed methods protocol.

Background: Health inequalities are a well-known and widespread phenomenon throughout health care settings. In particular, people of color experience higher rates of delayed and/or misdiagnosis contributing to poorer outcomes and an increased mortality risk. Research suggests that health care professionals find it more difficult to correctly diagnose dermatological conditions in the non-White patient demographic.

Does climate change threaten delivery of HIV care in resource-limited settings?

Purpose Of Review: Extreme weather events (EWEs) pose a challenge to achieving UNAIDS goal of eliminating HIV as a public health threat by 2030. This review summarizes recent findings describing the disruption of HIV services by EWEs and discusses strategies for a resilient HIV care programme in resource-limited settings.

Recent Findings: EWEs impact each component of the continuum of care - HIV testing, linkage to treatment, viral suppression and other HIV prevention services.

Short-term effects of opioids during therapeutic hypothermia for neonatal encephalopathy.

Objective: To examine the effects of opioids during therapeutic hypothermia (TH) on short-term outcomes in neonates with neonatal encephalopathy (NE).

Methods: Multicenter retrospective study of neonates with moderate/severe NE from Jan. 2013-Feb 2021.

A roadmap for navigating partner engagement in community-based autopsy studies: Lessons from the field in rural KwaZulu-Natal, South Africa.

Background: The measurement of cause-specific mortality is critical for health system planning but remains a challenge in many low-resource settings due to societal, legal, and logistical barriers. We present a co-development process with community members for the design and implementation of an autopsy program to improve cause of death data in a historically underserved population.

Methods: We sought to develop an autopsy program at the Africa Health Research Institute (AHRI) Health and Demographic Surveillance Site (HDSS).