Functional Outcomes of the Management of Acromioclavicular Joint Dislocation With a Clavicle Hook Plate: A Retrospective Study.

Background: Dislocation of the acromioclavicular joint (ACJ), accounting for 9%-12% of all shoulder injuries, is a frequent shoulder problem. Clavicular hook plates have proven to be a successful implant choice for surgical management. The benefit of this method is that it preserves the diarthrosis of the ACJ while reducing dislocation.

Predictive properties of novel anthropometric and biochemical indexes for prediction of cardiovascular risk.

Objective: Our aim was to examine the correlation between CVDs and various anthropometric and biochemical indices in the Iranian population.

Methods: 9704 healthy individuals without CVD aged 35-65 were enrolled in our study. The anthropometric indices including Body Adiposity Index (BAI), Abdominal Volume Index (AVI), Body Roundness Index (BRI), Waist to Hip Ratio (WHR), Weight-adjusted Waist Index (WWI), Conicity Index (C-Index), A Body Shape Index (ABSI), Waist to Height Ratio (WHtR), Body Surface Area (BSA), Body Mass Index (BMI), Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) were calculated.

Evaluating the home-based intervention strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: findings from a randomised controlled trial.

Background: Correct and consistent condom use is the most effective method to reduce transmission of sexually transmitted infections (STIs).

Objective: To compare the HIS-UK intervention to usual condom information and distribution care for effect on chlamydia test positivity.

Methods: Trial design A 3-parallel arm randomised controlled trial (1:1:1 allocation, two intervention arms vs.

China's position and competitiveness in the global antibiotic value chain: implications for global health.

Background: Antibiotics are a key commodity for global health, and inadequate access is a major contributor to global mortality. COVID-19 has refocused attention on global pharmaceutical value chains and the need for sustainable and secure production and supply of key products, including antibiotics. Production of antibiotics and their active pharmaceutical ingredients is capital- and technology-intensive, however, and value chains are dominated by a limited number of countries.

Vehicle-to-Vehicle Flooding Datasets using MK5 On-board Unit Devices.

The availability of information is a key requirement for the proper functioning of any network. When the availability problem is brought to vehicular networks, it may hinder novel vehicular services and applications and potentially put human lives at risk, as malicious users can send a massive number of spurious packets to disrupt them. Although flooding attacks in vehicular contexts have been the focus of attention of the research community, most proposed datasets are generated using simulated data and only contain the modeled network's behavior.

Non-operative Versus Operative Management of Perianal Abscess in Infants: A 10-year Retrospective Study at Two Centres in the United Kingdom.

Background: Perianal abscess (PA), with or without fistula-in-ano (FIA) is common in infants. Treatment options include incision and drainage under general anaesthesia or non-operative treatments, such as antibiotics and/or aspiration under local anaesthetic, which avoid the risks of surgery. Current management is based on surgeon preference due to a poor underlying evidence base.

Exploring the relationship between shared identity and interoperability: a mixed methods analysis of discussion-based multi-agency emergency response exercises.

Previous research has shown ongoing difficulties between Police, Fire and Rescue, and Ambulance Service responders during multi-agency emergencies. Recently, researchers have used the Social Identity Approach to gain insight into these challenges, offering a psychological framework for understanding relations within and between response organisations. This study builds upon previous work by engaging responders from the emergency services in six discussion-based exercises.

Role for the PIP-binding protein myristoylated alanine-rich C-kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease.

In vascular smooth muscle cells (VSMCs) and vascular endothelial cells (VECs), phosphatidylinositol 4,5-bisphosphate (PIP) acts as a substrate for phospholipase C (PLC)- and phosphoinositol 3-kinase (PI3K)-mediated signaling pathways and an unmodified ligand at ion channels and other macromolecules, which are key processes in the regulation of cell physiological and pathological phenotypes. It is envisaged that these distinct roles of PIP are achieved by PIP-binding proteins, which act as PIP buffers to produce discrete pools of PIP that permits targeted release within the cell. This review discusses evidence for the expression, cell distribution, and role of myristoylated alanine-rich C-kinase substrate (MARCKS), a PIP-binding protein, in cellular signaling and function of VSMCs.

Evaluating the SAFE Tool's Impact on Documentation and Patient Safety During Structured Ward Rounds in General Surgery: A Retrospective Study.

Aim  Effective documentation of critical clinical information is vital for patient safety and timely discharges. Ward rounds (WRs) are crucial for multidisciplinary assessments and care planning. Current emergency surgical WR documentation is inconsistent; therefore, this study will implement a structured WR template adapted from the Royal College of Surgeons of Edinburgh's "Surgical Assessment for Emergencies Ward Round Tool" (SAFE) to address these shortcomings.

Towards standardization of person-reported outcomes (PROs) in pediatric diabetes research: A consensus report.

Background: Diabetes ranks among the most common chronic conditions in childhood and adolescence. It is unique among chronic conditions, in that clinical outcomes are intimately tied to how the child or adolescent living with diabetes and their parents or carers react to and implement good clinical practice guidance. It is widely recognized that the individual's perspective about the impact of trying to manage the disease together with the burden of self-management should be addressed to achieve optimal health outcomes.

Higher identity resilience - self-efficacy is associated with sexual risk behaviours in gay men.

Cross-sectional survey data from 226 heterosexual and 201 gay men in the UK and Germany, analysed using moderation analyses, showed a positive relationship between identity resilience -self-efficacy and engaging in condomless sex and drug use in sexualised settings in gay men only. It is proposed that higher self-efficacy may lead to increased feelings of invincibility in gay men, which in turn is associated with sexual risk-taking.

Enhancing Pain Management and Psychological Recovery in Earthquake Victims: The Role of Continuous Regional Analgesic Techniques Assessed by QoR-15.

Background/objectives: After the earthquakes in Turkey, many citizens were injured, and a long ongoing process requiring physiological and psychological treatments began. The aim of this study was to observe the pain and psychological changes in earthquake victims in light of the QoR-15 score.

Methods: After approval by the local ethics committee (Decision No.

The Mini-Cog: A Community Screening Tool for Dementia in Indonesia.

Background: Early detection of dementia enables more effective planning and can enable access to treatment and support. The Mini-Cog is a widely used screening instrument in Indonesia; however, this instrument has never undergone a translation and cultural adaptation process. Currently, there is no data on how accurate the tool is against diagnostic criteria, particularly in low-education.

Predictors of outcome following psychological therapy for depression and anxiety in an urban primary care service: a naturalistic Bayesian prediction modeling approach.

Background: England's primary care service for psychological therapy (Improving Access to Psychological Therapies [IAPT]) treats anxiety and depression, with a target recovery rate of 50%. Identifying the characteristics of patients who achieve recovery may assist in optimizing future treatment. This naturalistic cohort study investigated pre-therapy characteristics as predictors of recovery and improvement after IAPT therapy.

The Relationship Between Cognitive Emotion Regulation Strategy and Mental Health Among University Students During Public Health Emergency: A Network Analysis.

Background: Public health emergencies pose threats to mental health, and cognitive emotional regulation can be a crucial coping strategy. This study explored the relationship between cognitive emotion regulation strategies and mental health among university students during the COVID-19 pandemic using network analysis.

Methods: 1100 university students completed questionnaires assessing depression, anxiety, somatization, and cognitive emotion regulation strategies.

Participatory longitudinal qualitative interview study to understand Autistic gynaecological and obstetric health: the Autism from menstruation to menopause study protocol.

Introduction: Autism is a lifelong minority neurotype present from birth. There is a dearth of credible evidence to suggest gender variation in Autism prevalence, despite historical under-diagnosis of women. Autistic people Assigned Female At Birth (AFAB) have worse physical and mental health compared with non-Autistic peers.

Bilateral Urrets-Zavalia syndrome after uneventful Descemet membrane endothelial keratoplasty.

Urrets-Zavalia syndrome (UZS) stands out as a rare yet clinically consequential complication associated with ophthalmic surgery, marked by the emergence of a fixed and dilated pupil. While it was originally described post-penetrating keratoplasty (PKP) in patients with keratoconus and its prevalence is notably higher following PKP, instances of UZS have been documented in the context of other procedures, including intraocular lens implantation, Descemet-stripping endothelial keratoplasty and Descemet membrane endothelial keratoplasty (DMEK). We report a unique case of bilateral UZS after uneventful DMEK surgeries, highlighting a rare but potential complication after DMEK.

Enhanced antitumor immunity in breast cancer: Synergistic effects of ADAM10/ADAM17 inhibition, metabolic modulation, and camptothecin-loaded selenium nanoparticles.

Background: In this study, we investigate the impact of a multi-targeted therapeutic approach that includes camptothecin (CPT), a potent chemotherapeutic topoisomerase inhibitor; metformin (Met), a metabolic modulator with emerging anti-tumor effects; and GW280264X, an inhibitor of ADAM 10/ADAM 17 enzymes, which are associated with tumor invasion and immune response. The study aims to assess the combined effects of these agents in enhancing CD8 T cell-mediated anti-tumor immunity and suppressing cancer cell growth in triple-negative breast cancer (TNBC) models, both in vitro and in vivo.

Methods: Cell viability was performed on the 4 T1 human TNBC cell line.

Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.

Background: Optimal therapy following breast-conserving surgery in older adults with low-risk, early-stage breast cancer remains uncertain. The EUROPA trial aims to compare the effects of radiotherapy and endocrine therapy as single-modality treatments on health-related quality of life (HRQOL) and ipsilateral breast tumour recurrence (IBTR) outcomes in this population.

Methods: This non-inferiority, phase 3, randomised study was conducted at 18 academic hospitals across Italy (17 centres) and Slovenia (one centre).

Perceived body acceptance by personal trainers and client body appreciation in women in the UK: A pre-registered study.

Research is yet to consider the potential for personal trainers (PTs) to influence their client's thoughts and feelings surrounding their body. This pre-registered study explored a model of positive body image in women personal training clients in the UK. Participants (n = 234, mean age = 51) completed an online questionnaire assessing body mass index (BMI), perceived body acceptance by their PT and various other measures related to body image.

Influence of gingival margin height variation on perceived aesthetics following absent maxillary lateral incisor-canine substitution.

Background: Maxillary lateral incisor agenesis is often managed with orthodontic space closure and canine substitution. Anatomic gingival margin heights associated with the maxillary anterior teeth are considered important for achieving aesthetic excellence with space closure, but evidence relating to the perceptions of lay people is poor.

Objectives: This study investigated the influence of gingival margin height variation in the maxillary anterior teeth following orthodontic space closure and canine substitution in the absence of maxillary lateral incisor teeth on perceived aesthetics judged by a lay population.

Probing CPT Invariance with Top Quarks at the LHC.

The first model-independent sensitivity to CPT violation in the top-quark sector is extracted from ATLAS and CMS measurements of the top and antitop kinematical mass difference. We find that the temporal component of a CPT-violating background field interacting with the top-quark vector current is restricted within the interval [-0.13,0.

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics.

The spatiotemporal configuration of genes with distal regulatory elements is believed to be crucial for transcriptional control, but full mechanistic understanding is lacking. We combine simultaneous live tracking of pairs of genomic loci and nascent transcripts with molecular dynamics simulations to assess the gene and its enhancer. We find that both loci exhibit more constrained mobility than control sequences due to stalled cohesin at CCCTC-binding factor sites.