A qualitative investigation of addiction counselors' perceptions and experiences implementing an open-access model for treating opioid use disorder.

Objective: To examine addiction counselors' perceptions and experiences of implementing an open-access model for methadone maintenance treatment (MMT), in which the program rapidly enrolled prospective patients, irrespective of ability to pay, and provided real-time access to multiple voluntary treatment options. Between 2006, when the treatment program initially implemented this model, and 2020, the census of clients receiving methadone maintenance at the study site grew from 1431 to 4500.

Methods: Participants were 31 addiction counselors employed at a treatment organization that implemented an open-access model to scale up MMT.

Chiropractic Care of a Patient With Complex Regional Pain Syndrome Type 1 (CRPS-1): A Case Report.

Objective: The purpose of this case report is to describe the evaluation and treatment of a patient presenting with left upper extremity pain and neck pain after a slip and fall.

Clinical Features: A 56-year-old woman sustained a left distal radius fracture secondary to a slip-and-fall accident. She was placed in a cast for 6 weeks, and after the removal of her cast she developed excruciating left forearm, wrist, hand, and finger pain.

Enhanced Deep Learning Architectures for Face Liveness Detection for Static and Video Sequences.

Face liveness detection is a critical preprocessing step in face recognition for avoiding face spoofing attacks, where an impostor can impersonate a valid user for authentication. While considerable research has been recently done in improving the accuracy of face liveness detection, the best current approaches use a two-step process of first applying non-linear anisotropic diffusion to the incoming image and then using a deep network for final liveness decision. Such an approach is not viable for real-time face liveness detection.

Misinformation, chiropractic, and the COVID-19 pandemic.

Background: In March 2020, the World Health Organization elevated the coronavirus disease (COVID-19) epidemic to a pandemic and called for urgent and aggressive action worldwide. Public health experts have communicated clear and emphatic strategies to prevent the spread of COVID-19. Hygiene rules and social distancing practices have been implemented by entire populations, including 'stay-at-home' orders in many countries.

Alexithymia and pain experience among patients using methadone-maintenance therapy.

Background: Alexithymia, difficulty identifying and describing one's emotions coupled with a tendency to externalize, is a potentially important yet understudied treatment target for patients with opioid use disorder. The aim of this study was to examine the role of alexithymia in pain experience among individuals with opioid use disorder.

Methods: One-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences.

Correlates of Homelessness Among Patients in Methadone Maintenance Treatment.

Background: Although homelessness and opioid use disorder (OUD) are important public health issues, few studies have examined their cooccurrence.

Objectives: The aim of this study was to evaluate the correlates of homelessness among patients enrolled in low-barrier-to-treatment-access methadone maintenance treatment (MMT) programs for OUD.

Methods: Demographic, diagnosis-related, and treatment-related correlates were assessed by self-report for 164 patients in MMT.

Families in Transition: The Lived Experience of Parenting a Transgender Child.

Research exploring the parents' experience of their child undergoing gender transition is almost nonexistent. However, as the number of individuals who identify as transgender increases, gender identity will continue to evolve; therefore, supporting families of these individuals is paramount. Parents of transgender children were interviewed and yielded five themes: (a) It Rocks Your World; (b) Dancing Around in a Way that Doesn't Distance; (c) Your Child Is Still Your Child; (d) Worrying About the Future; and (e) Transformational: Finally an Answer.

Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment.

Purpose: The aim of this study was to evaluate the prevalence and clinical correlates of impaired sleep quality and excessive daytime sleepiness among patients receiving methadone for opioid use disorder (OUD).

Methods: Patients receiving methadone (n = 164) completed surveys assessing sleep quality (Pittsburgh Sleep Quality Index [PSQI]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), and related comorbidities. We used bivariate and multivariable linear regression models to evaluate correlates of sleep quality and daytime sleepiness.

Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.

Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here, we used 2D and 3D human brain cultures to investigate MeCP2 function. We found that MeCP2 mutations cause severe abnormalities in human interneurons (INs).

Dry needling for spine related disorders: a scoping review.

Introduction/background: The depth and breadth of research on dry needling (DN) has not been evaluated specifically for symptomatic spine related disorders (SRD) from myofascial trigger points (TrP), disc, nerve and articular structures not due to serious pathologies. Current literature appears to support DN for treatment of TrP. Goals of this review include identifying research published on DN treatment for SRD, sites of treatment and outcomes studied.

Response of Chiropractic Organizations to the COVID-19 Pandemic: A Descriptive Report.

Objective: The purpose of this report is to describe actions by chiropractic entities during the early stages of the coronavirus disease 2019 (COVID-19) pandemic.

Methods: Large entities that support chiropractic education or practice were invited to participate in this report. Leaders of various entities were emailed an invitation.

Graphene Quantum Dot Oxidation Governs Noncovalent Biopolymer Adsorption.

Graphene quantum dots (GQDs) are an allotrope of carbon with a planar surface amenable to functionalization and nanoscale dimensions that confer photoluminescence. Collectively, these properties render GQDs an advantageous platform for nanobiotechnology applications, including optical biosensing and delivery. Towards this end, noncovalent functionalization offers a route to reversibly modify and preserve the pristine GQD substrate, however, a clear paradigm has yet to be realized.

Progress in the Mechanism and Clinical Application of Cilostazol.

Cilostazol is a unique platelet inhibitor that has been used clinically for more than 20 years. As a phosphodiesterase type III inhibitor, cilostazol is capable of reversible inhibition of platelet aggregation and vasodilation, has antiproliferative effects, and is widely used in the treatment of peripheral arterial disease, cerebrovascular disease, percutaneous coronary intervention, etc. This article briefly reviews the pharmacological mechanisms and clinical application of cilostazol.

Cross-kingdom analysis of nymphal-stage Ixodes scapularis microbial communities in relation to Borrelia burgdorferi infection and load.

The tick microbiota may influence the colonization of Ixodes scapularis by Borrelia burgdorferi, the Lyme disease bacterium. Using conserved and pathogen-specific primers we performed a cross-kingdom analysis of bacterial, fungal, protistan and archaeal communities of I. scapularis nymphs (N = 105) collected from southern Vermont, USA.

Engineering of human brain organoids with a functional vascular-like system.

Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs), provide a platform to study human brain development and diseases in complex three-dimensional tissue. However, current hCOs lack microvasculature, resulting in limited oxygen and nutrient delivery to the inner-most parts of hCOs. We engineered hESCs to ectopically express human ETS variant 2 (ETV2).

"Day-to-day, it's a roller coaster. It's frustrating. It's rewarding. It's maddening and it's enjoyable": A qualitative investigation of the lived experiences of addiction counselors.

Psychologists in medication for addiction treatment (MAT) settings routinely oversee the work of addiction counselors as supervisors, administrators, and human resource specialists. Limited research has explored the lived experiences of counselors who work in programs that have scaled-up MAT in response to the opioid crisis in the U.S.

The crural interosseous membrane re-visited: a histological and microscopic study.

The aim of this study was to characterize the microscopic structure and sensory nerve endings of the crural interosseous membrane (IM). 13 IMs from 7 cadavers were used to analyze the organization of the collagen fibers, IM's thickness, distribution of elastic fibers and nerve elements. The IM is mainly a two-layer collagen fascicle structure with the collagen fibers of adjacent layers orientated along different directions, forming angles of 30.

Pain catastrophizing and pain acceptance are associated with pain severity and interference among methadone-maintained patients.

Objective: The present study examined whether pain catastrophizing and pain acceptance, two important targets of psychosocial interventions for chronic pain, are uniquely associated with pain severity and pain interference among patients on methadone maintenance treatment (MMT).

Method: A total of 133 MMT patients who reported experiencing some pain during the previous week completed a battery of self-report measures. Multiple regression was used to test whether pain catastrophizing and pain acceptance are related to pain severity and pain interference above and beyond covariates including demographics, emotional distress, and current methadone dose.

Estimation of electronic waste using optimized multivariate grey models.

Rapid and revolutionary changes in technology and rising demand for consumer electronics have led to staggering rates of accumulation of electrical and electronic equipment waste, viz., WEEE or e-waste. Consequently, e-waste has become one of the fastest growing municipal solid waste streams in the United States making its efficient management crucial in supporting the efforts to create and sustain green cities.

Flu Outbreak Prediction Using Twitter Posts Classification and Linear Regression With Historical Centers for Disease Control and Prevention Reports: Prediction Framework Study.

Background: Social networking sites (SNSs) such as Twitter are widely used by diverse demographic populations. The amount of data within SNSs has created an efficient resource for real-time analysis. Thus, data from SNSs can be used effectively to track disease outbreaks and provide necessary warnings.

Personalized Nutrition: Translating the Science of NutriGenomics Into Practice: Proceedings From the 2018 American College of Nutrition Meeting.

Adverse reactions to foods and adverse drug reactions are inherent in product defects, medication errors, and differences in individual drug exposure. Pharmacogenetics is the study of genetic causes of individual variations in drug response and pharmacogenomics more broadly involves genome-wide analysis of the genetic determinants of drug efficacy and toxicity. The similarity of nutritional genomics and pharmacogenomics stems from the innate goal to identify genetic variants associated with metabolism and disease.