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The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo.
Nucleic Acids Res
March 2010
Institute of Genetics, University of Braunschweig TU, Spielmannstr. 7, 38106 Braunschweig, Germany.
The spliceosomal protein Prp1 (Prp6/U5-102 K) is necessary for the integrity of pre-catalytic spliceosomal complexes. We have identified a novel regulatory function for Prp1. Expression of mutations in the N-terminus of Prp1 leads to the accumulation of pre-catalytic spliceosomal complexes containing the five snRNAs U1, U2, U5 and U4/U6 and pre-mRNAs.
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