Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging.

Background: The aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.

Objective: This study investigates the efficacy of a novel topical formulation, OS-01 EYE, containing the senomorphic peptide, OS-01, along with other active ingredients, in improving the skin around the eyes.

Methods: A 12-week clinical study was conducted with 22 participants who applied OS-01 EYE twice daily.

Macauba (Acrocomia ssp.) fruits: A comprehensive review of nutritional and phytochemical profiles, health benefits, and sustainable oil production.

Macauba is an underexplored palm with significant potential for food-grade vegetable oil production. Its fruits yield two distinct sources of oil, the pulp and the kernel, each with its unique composition, emerging as a potential vegetable oil source with high competitiveness with well-established conventional oil sources. Besides the oil, macauba fruits are rich in essential nutrients, including proteins, minerals, vitamins, dietary fiber, and phytochemicals, with outstanding health benefits.

Changes in phosphorus due to pyrolysis and in the soil-plant system amended with sewage sludge biochar compared to conventional P fertilizers: A global meta-analysis.

Phosphorus (P) plays an essential role for plant growth, but conventional P sources used in agriculture are finite and non-renewable. As a result, there is a growing need to explore alternative P sources such as sewage sludge (SS) - a P-rich solid waste and valuable renewable resource that is often mismanaged globally. Pyrolysis is a promising technique for managing SS.

Predicting Irida-Silicene: A Novel 2D Silicon Allotrope.

Two-dimensional (2D) silicon-based materials have garnered significant attention for their promising properties, making them suitable for various advanced technological applications. Here, we present Irida-Silicene (ISi), a novel 2D silicon allotrope inspired by Irida-Graphene (IG), which was recently proposed and is entirely composed of carbon atoms. ISi exhibits a buckled structure composed of 3-6-8 membered rings, unlike its planar carbon counterpart.

Mucormycosis Causing Splenic Infarction, Gastric Fistula, and Brain Abscess in a Patient With Acute Myeloid Leukemia: A Case Report.

Invasive mucormycosis is an aggressive fungal infection characterized by rapid progression, primarily impacting immunocompromised individuals. Herein, we report a case of splenic infarction in association with gastrointestinal fistula and brain abscess as a rare presentation of mucormycosis biopsy, proven in a 56-year-old patient diagnosed with acute myeloid leukemia. The patient initially sought medical attention with a 3-week history of fever, night sweats, and malaise.

Electrostatic Orientation of Optically Asymmetric Janus Particles.

Janus micro- and nanoparticles, featuring unique dual-interface designs, are at the forefront of rapidly advancing fields such as optics, medicine, and chemistry. Accessible control over the position and orientation of Janus particles within a cluster is crucial for unlocking versatile applications, including targeted drug delivery, self-assembly, micro- and nanomotors, and asymmetric imaging. Nevertheless, precise mechanical manipulation of Janus particles remains a significant practical challenge across these fields.

Nasal telangiectatic osteosarcoma with direct extension to the brain in a domestic shorthair cat.

Case Summary: This case report describes the clinical and pathological features of telangiectatic osteosarcoma (TOS) with brain invasion in a 4-year-old female domestic shorthair cat. The cat presented with respiratory distress, epistaxis, anorexia and significant nasal obstruction. A rhinoscopy revealed an amorphous white neoformation in the left nasal cavity.

Exploring the electronic and mechanical properties of the recently synthesized nitrogen-doped amorphous monolayer carbon.

The recent synthesis of nitrogen-doped amorphous monolayer carbon (NAMC) opens new possibilities for multifunctional materials. In this study, we have investigated the nitrogen doping limits and their effects on NAMC's structural and electronic properties using density functional-based tight-binding simulations. Our results show that NAMC remains stable up to 35% nitrogen doping, beyond which the lattice becomes unstable.

Sarcopenia in the Oldest-Old Adults in the Capital of Brazil: Prevalence and Its Associated Risk Factors.

Background: In light of the demographic context in which the older adult population is prominent, sarcopenia emerges as a significant concern for the health of these individuals.

Aim: To assess the frequency of sarcopenia and severe sarcopenia and the associated risk factors in the oldest adults living in the community.

Methods: There were 399 participants aged 80 or older, of both sexes, using primary health care services in the metropolitan area of Brasília, Brazil.

Association Between SARC-F and Clinical Outcomes in Older Adults With Cardiovascular Diseases Admitted to the Emergency Room: A Longitudinal Study.

Introduction: Sarcopenia can be more significant and severe in the presence of cardiovascular diseases. In hospitalized older adults with acute cardiac disease, assessing strength parameters, muscle mass, and physical performance is difficult largely because of bed rest restrictions. In this context, simple questionnaire to rapidly diagnose sarcopenia (SARC-F) emerges as a feasible screening tool to identify sarcopenia in an emergency room setting.

Cis-eQTL analysis reveals genes involved in biological processes of the immune system in Nelore cattle.

The combination of transcriptional profiling and genotype data analyses enables the identification of genetic variants that may affect gene expression (eQTL - expression quantitative trait loci). This study aimed to identify cis-eQTL in Nellore cattle muscle tissue and determine their biological processes related to the immune system and involved eGenes. Genotypic data (SNP-Chip) and gene expression data (RNA-Seq) from a commercial population of 80 Nellore animals were evaluated.

Fluence smoothing evaluation for whole-breast automatically generated treatment plans.

Purpose: This study aimed to identify the fluence smoothing threshold that preserves the dosimetric quality of planning for breast cancer intensity-modulated radiation therapy (IMRT).

Material And Methods: We conducted automated treatment planning for 60 breast cancer patients using the Eclipse Scripting Application Programming Interface. The plans included four-field IMRT, emphasizing smoothing weight combinations while maintaining a 4:3 aspect ratio between the X and Y directions.

Enhancing Forensic Laboratories Through University Collaboration: Obtaining Conclusive Reports and Reference Materials via NMR.

Forensic laboratories play a pivotal role in identifying and quantifying drugs in police seizures, often using spectroscopic techniques in combination with chromatographic methods that rely on chemical reference substances (CRS). The demand for a wide variety of CRS is critical, not only for common drugs like cocaine but also for the rapidly increasing number of new psychoactive substances (NPS), which emerge weekly. However, acquiring CRS is costly and bureaucratic because of the restricted circulation of these substances.

Upper-Extremity physical performance tests in older adults: Reference values, reliability and measurement error.

Background: Physical performance tests are reliable tools to assess aspects related to strength, power, and mobility. Unfortunately, few studies were performed with older adults. The main goal of this study was to describe reference values for the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) and Upper Quarter Y Balance Test (UQYBT) in older adults and to determine differences based on sex.

Prognostic Scores for Acute Kidney Injury in Critically Ill Patients.

Background: Numerous prognostic scores have been developed and used in intensive care; however, the applicability and effectiveness of these scores in critically ill patients with acute kidney injury may vary due to the characteristics of this population.

Objective: To assess the predictive capacity of the Simplified Acute Physiology Score III (SAPS III), Sequential Sepsis-related Organ Failure Assessment (SOFA) and Nursing Activities Score (NAS) prognostic scoring systems for acute kidney injury in critically ill patients.

Methods: Cohort, prospective and quantitative study with follow-up of 141 critical patients in intensive care.

Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies.

A promising approach for managing root caries is the use of cross-linking agents to stabilize collagen. However, despite testing various natural and synthetic agents in vitro, their efficacy remains uncertain. The aim of this review was to examine which cross-linking agent performs better in reducing root caries lesion depth and the release of hydroxyproline, which is a marker of collagen degradation.

Removal of Chlorhexidine for Ventilator-Associated Pneumonia Prevention with a Dentist Composing the Intensive Care Unit Team.

Purpose: An association between the use of chlorhexidine in mechanically ventilated patients for the purpose of oral hygiene and the prevention of ventilator-associated pneumonia (VAP) lacks conclusive evidence in the literature. Therefore, this study aims to assess the clinical impact of such practice. This evaluation will consider that retention factors, infection foci, and oral biofilm will be regularly removed by a dentist.

Female homicides in Brazil: global burden of disease study, 2000-2018.

Background: Female homicides are a public health-relevant issue, and its spatial distribution may evidence socioeconomic vulnerabilities. This study aims to analyze the temporal and spatial trends of female homicides in Brazil and investigate socioeconomic-demographic factors associated with it.

Methods: This is an ecological, descriptive, and analytical epidemiological study investigating the age-standardized female homicide rate in all Brazilian municipalities between 2000 and 2018, divided into three periods.

Insecticide-impregnated dog collars for the control of visceral leishmaniasis: evaluation of the susceptibility of field Lutzomyia longipalpis populations to deltamethrin.

Background: Visceral leishmaniasis (VL) is a zoonotic disease caused by Leishmania infantum and transmitted by the sand fly Lutzomyia longipalpis. Dogs are the major domestic reservoir of L. infantum.