5,988 results match your criteria: "University of Bourgogne & Inserm[Affiliation]"
Eur J Paediatr Neurol
November 2024
Movement Disorders Unit, Pediatric Neurology Department, Institut de Recerca, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain; European Reference Network for Rare Neurological Diseases (ERN-RND), Barcelona, Spain; U-703 Centre for Biomedical Research on Rare Diseases (CIBER-ER), Instituto de Salud Carlos III, Barcelona, Spain. Electronic address:
Background And Objectives: Developmental and epileptic encephalopathy 56 (DEE-56) is caused by pathogenic variants in YWHAG and is characterized by early-onset epilepsy and neurodevelopmental delay. This study reports on a cohort of DEE-56 individuals, correlating antiseizure medication usage and comorbidities, to aid in understanding disease evolution.
Methods: We analyzed data from thirty-nine individuals aged 3-40 years with YWHAG variants, including 12 previously unreported individuals (2 of these with recurrent distal 7q11.
Public Health
December 2024
Department of General Practice, University of Paris-Saclay, France; CESP (Centre for Research in Epidemiology and Population Health), Inserm U1018, University of Paris-Saclay, UVSQ, Gender, Sexual and Reproductive Health Team, Paris, France.
Objectives: We studied the socio-spatial inequalities of three types of general practitioner (GP) density in the Paris metropolitan area: the density of GPs present (that is, practising) in the census block and of those registering new patients for office visits and, separately, for house calls.
Study Design: An exhaustive simulated patient survey enabled us to determine the number of GPs practising in the Paris metropolitan region accepting new patient registration for continuing care at their office and/or for house calls.
Methods: We measured at the level of a census block three types of GP densities: density of GPs present, density of GPs registering new patients at their office and density of GP registering new patients for house calls.
Nat Commun
October 2024
Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 CNRS, Université de Bourgogne, F-21000, Dijon, France.
Ultrafast fiber lasers constitute a flexible platform to investigate new solitary wave concepts. To surpass the low energy limitation of the conventional solitons generated in standard telecom fibers, successive breakthroughs have promoted the usage of an important frequency chirping within fiber oscillators. This lead to original solitary wave regimes such as stretched-pulse, all-normal-dispersion, and self-similar dynamics.
View Article and Find Full Text PDFBrain
October 2024
Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
DDX17 is an RNA helicase shown to be involved in critical processes during the early phases of neuronal differentiation. Globally, we compiled a case-series of 11 patients with neurodevelopmental phenotypes harbouring de novo monoallelic variants in DDX17. All 11 patients in our case series had a neurodevelopmental phenotype, whereby intellectual disability, delayed speech and language, and motor delay predominated.
View Article and Find Full Text PDFChem Senses
January 2024
Institut de Chimie de Nice, UMR 7272, Université Côte d'Azur, Nice, France.
Olfactory perception begins when odorous substances interact with specialized receptors located on the surface of dedicated sensory neurons. The recognition of smells depends on a complex mechanism involving a combination of interactions between an odorant and a set of odorant receptors (ORs), where molecules are recognized according to a combinatorial activation code of ORs. Although these interactions have been studied for decades, the rules governing this ligand recognition remain poorly understood, and the complete combinatorial code is only known for a handful of odorants.
View Article and Find Full Text PDFJ Food Sci Technol
November 2024
Department of Food Engineering and Technology, Institute of Biosciences, Humanities and Exact Sciences (Ibilce), São Paulo State University (Unesp), Campus São José Do Rio Preto, Rua Cristóvão Colombo, 2265, São José Do Rio Preto, SP CEP 15054-000 Brazil.
Unlabelled: Thermoplastic extrusion is important in processing a wide variety of food products. In this paper, the effects of different extrusion conditions, addition of vegetable oil and the food matrix itself on the physical and sensory characteristics of corn snacks and meat analogs were evaluated. Cysteine and butyric acid (cheese aroma precursors) and thiamine (a meat aroma precursor) were added to corn grits and soy protein concentrate, respectively, before extrusion.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
October 2024
Department of Orthopaedic Surgery, Dijon University Hospital, Dijon, France; INSERM, UMR1093-CAPS, Université Bourgogne Franche-Comté, UB, Dijon, France; INSERM, CIC 1432, Module Plurithématique, Plateforme d'Investigation Technologique, Dijon, France.
Background: Chronic anterior shoulder instability affects a young and athletic population, with a high demand for functional recovery and return to sport. The arthroscopic Trillat dynamic stabilization technique has shown great results at 2 years in terms of stabilization and functional outcomes on the general population. The hypothesis is that it could do so in at-risk for dislocation athletic population for stabilization and return to sport, with results comparable to the reference techniques.
View Article and Find Full Text PDFBiol Psychiatry
October 2024
Fondation Fondamental, Créteil, France; Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Emergency Department, Pole Urgence, Montpellier, France; L'Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France. Electronic address:
Appl Environ Microbiol
November 2024
Laboratory of Virology, University Hospital of Dijon Bourgogne, Dijon, France.
The aim of this study was to evaluate whether community-level monitoring of respiratory and enteric viruses in wastewater can provide a comprehensive picture of local virus circulation. Wastewater samples were collected weekly at the wastewater treatment plant (WWTP) inlet and at the outlet of a nearby nursing home (NH) in Burgundy, France, during the winter period of 2022/2023. We searched for the pepper mild mottle virus as an indicator of fecal content as well as for the main respiratory viruses [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, and respiratory syncytial virus] and enteric viruses (rotavirus, sapovirus, norovirus, astrovirus, and adenovirus).
View Article and Find Full Text PDFMed Image Anal
January 2025
ImViA EA 7535/ IFTIM, Université de Bourgogne, 21078 Dijon, France.
Sci Total Environ
December 2024
Institute of Environmental Sciences, Leiden University, P.O. Box 9518, 2300 RA Leiden, the Netherlands. Electronic address:
Terrestrial systems are a significant sink for plastic contamination, including nano- and microplastics (NMPs). To date, limited information is available about the transfer of NMPs up the food web via trophic transfer, however, concerns about this exposure pathway for invertebrates and higher-level organisms have been raised. We aim to examine and quantify the trophic transfer of europium doped polystyrene nanoplastics (Eu-PS; NPs) within a terrestrial food chain.
View Article and Find Full Text PDFOphthalmol Sci
August 2024
University of Bordeaux, INSERM, BPH, U1219, F-33000 Bordeaux, France.
Purpose: Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.
View Article and Find Full Text PDFBMC Med Ethics
October 2024
Famiréa Research Group, Medical Intensive Care Unit, APHP, Hospital Saint-Louis, Paris, France.
Front Vet Sci
September 2024
Agroécologie, INRAE, Institut Agro, Université de Bourgogne, Université Bourgogne Franche-Comté, Dijon, France.
J Hematol Oncol
October 2024
Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Int J Sports Physiol Perform
December 2024
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico," Rome, Italy.
Steroids
December 2024
Laboratoiry Bio-PeroxIL / EA7270, Université de Bourgogne / Inserm, 21000 Dijon, France; PHYNOHA Consulting, 21121 Fontaine-lès-Dijon, France. Electronic address:
Phytosterols are plant sterols that are important secondary plant metabolites with significant pharmacological properties. Their presence in the plant kingdom concerns many unrelated botanical families such as oleageneous plants and cereals. The structures of phytosterols evoke those of cholesterol.
View Article and Find Full Text PDFAccess Microbiol
October 2024
Laboratory of Physiopathology and Molecular Genetics, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca (Morocco), Avenue Cdt Driss El Harti, PB 7955 Sidi Othman, Casablanca, Morocco.
During the 3 years following the emergence of the COVID-19 pandemic, the African continent, like other regions of the world, was substantially impacted by COVID-19. In Morocco, the COVID-19 pandemic has been marked by the emergence and spread of several SARS-CoV-2 variants, leading to a substantial increase in the incidence of infections and deaths. Nevertheless, the comprehensive understanding of the genetic diversity, evolution, and epidemiology of several viral lineages remained limited in Morocco.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
Viruses are abundant and ubiquitous in soil, but their importance in modulating greenhouse gas (GHG) emissions in terrestrial ecosystems remains largely unknown. Here, various loads of viral communities are introduced into paddy soils with different fertilization histories via a reciprocal transplant approach to study the role of viruses in regulating greenhouse gas emissions and prokaryotic communities. The results showed that the addition of viruses has a strong impact on methane (CH) and nitrous oxide (NO) emissions and, to a minor extent, carbon dioxide (CO) emissions, along with dissolved carbon and nitrogen pools, depending on soil fertilization history.
View Article and Find Full Text PDFFront Physiol
September 2024
INSERM UMR 1093 - Laboratoire CAPS, « Cognition, Action et Plasticité Sensorimotrice », Université de Bourgogne, Dijon, France.
An increasing body of evidence confirms the effectiveness of physical exercise (PE) in promoting brain health by preventing age-related cognitive decline and reducing the risk of neurodegenerative diseases. The benefits of PE are attributed to neuroplasticity processes which have been reported to enhance cerebral health. However, moderate to high-intensity PE is necessary to induce these responses and these intensities cannot always be achieved especially by people with physical limitations.
View Article and Find Full Text PDFSci Total Environ
December 2024
Agroécologie, INRAE, Institut Agro, Université de Bourgogne, Université de Bourgogne-Franche-Comté, Dijon, France.
Nat Ecol Evol
December 2024
Agroecology and Environment, Agroscope, Zürich, Switzerland.
Emerging infectious diseases pose a threat to pollinators. Virus transmission among pollinators via flowers may be reinforced by anthropogenic land-use change and concomitant alteration of plant-pollinator interactions. Here, we examine how species' traits and roles in flower-visitation networks and landscape-scale factors drive key honeybee viruses-black queen cell virus (BQCV) and deformed wing virus-in 19 wild bee and hoverfly species, across 12 landscapes varying in pollinator-friendly (flower-rich) habitat.
View Article and Find Full Text PDFNEJM Evid
December 2024
CERITD (Center for Study and Research for Improvement of the Treatment of Diabetes), Bioparc-Genopole Evry-Corbeil, 91042 Evry, France.
Background: Diabetic foot ulcers are chronic, difficult to heal, and potentially life-threatening. Few medical devices have been studied in diabetic ulcers penetrating to bone or tendon.
Methods: We conducted an international, open-label randomized controlled trial, randomly assigning patients with diabetic ulcers penetrating to bone, joint, or tendon 1:1 to intact fish skin graft or standard wound care, with assigned treatment applied through 14 weeks.
FEMS Microbiol Ecol
October 2024
Millennium Institute Biodiversity of Antarctic and Subantarctic Ecosystems (BASE), Santiago 7800003, Chile.
Conceptual biogeographic frameworks have proposed that the relative contribution of environmental and geographical factors on microbial distribution depends on several characteristics of the habitat (e.g. environmental heterogeneity, species diversity, and proportion of specialist/generalist taxa), all of them defining the degree of habitat specificity, but few experimental demonstrations exist.
View Article and Find Full Text PDFSci Rep
October 2024
Food Science and Technology Program, School of Agro-Industry, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
This study aimed to investigate the behavior of smart bilayer films under various temperature and relative humidity (RH). Smart bilayer films were fabricated using sodium alginate with incorporated butterfly pea anthocyanin and agar containing catechin-lysozyme. Cellulose nanospheres were added at concentrations of 0% and 10% w/w of the film and subjected to test at 4 °C and 25 °C, considering different RHs (0%, 50%, and 80%).
View Article and Find Full Text PDF