Medial arterial calcification of the lower limbs in diabetes: Time for awareness? A short narrative review.

In patients with diabetes, peripheral arterial disease, particularly below the knee, is associated with medial arterial calcification. This is a frequent and potentially serious complication, affecting all types of diabetes. In recent years, our understanding of the pathophysiology and clinical significance of medial arterial calcification has improved considerably.

Creation of Composite Aerogels Consisting of Activated Carbon and Nanocellulose Blended with Cross-Linked Biopolymers: Application as Ethylene Scavengers.

This study involved producing aerogels using activated carbon (AC) and nanocellulose (NC). Two distinct structured composites, AC composite aerogel (ACCA) and NC composite aerogel (NCCA), were developed by separately mixing AC and NC with identical proportions of cross-linked biopolymers: hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), and chitosan (C). These aerogels were evaluated for their capability to adsorb ethylene gas through batch experiments, while the physical and chemical characteristics were thoroughly examined to determine their feasibility of removing ethylene.

Artificial intelligence-based prediction of neurocardiovascular risk score from retinal swept-source optical coherence tomography-angiography.

The recent rise of artificial intelligence represents a revolutionary way of improving current medical practices, including cardiovascular (CV) assessment scores. Retinal vascular alterations may reflect systemic processes such as the presence of CV risk factors. The value of swept-source retinal optical coherence tomography-angiography (SS OCT-A) imaging is significantly enhanced by image analysis tools that provide rapid and accurate quantification of vascular features.

Diffuse lung diseases ascribed to drugs: a nationwide observational study over 37 years using the French pharmacovigilance database.

Background: Drug-induced interstitial lung disease (DI-ILD) is a heterogeneous subgroup of interstitial lung diseases (ILD). The number of molecules involved is increasing with time. Due to their low incidence, DI-ILDs may be detected only after a drug has been marketed, notably through Adverse Drug Reaction (ADR) reports to pharmacovigilance centres.

Classic Hodgkin Lymphoma: The LYSA pragmatic guidelines.

Classic Hodgkin lymphoma (HL) is a distinct entity among hematological malignancies of B-cell origin. It is characterized by its unique histopathological features and generally favorable prognosis. Over the years, advancements in understanding its pathogenesis, coupled with refined diagnostic and evaluation modalities, as well as therapeutic strategies, have significantly transformed the landscape of HL management.

Morphological complexity promotes origination and extinction rates in ammonoids.

The causes of heterogeneity in evolutionary rates are a key question in macroevolution. Origination and extinction rates are closely related to abiotic factors, such as climate and geography, as well as biotic factors such as taxonomic richness and morphology, which are influenced by phylogeny. Studies on the relationship between morphology and macroevolution have focused on morphological traits, including body size, shape, color, and complexity, and have proposed biological laws, such as the zero-force evolutionary law and Cope's rule.

Six-year follow-up of phase II study exploring chemo-free treatment association with idelalisib and obinutuzumab in symptomatic relapsed/ refractory patients with Waldenström's macroglobulinemia.

We present the 6-year update of a phase 2 study evaluating the combination of obinutuzumab and idelalisib in relapse/refractory Waldenstrom macroglobulinemia. The results of the REMODEL trial demonstrated interesting efficacy in a high-risk genotype profile population. The primary endpoint was achieved with a median PFS of 25.

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model.

Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response. Conversely, RT also promotes an immunosuppressive TME notably through the recruitment of regulatory T cells (Tregs). Glycoprotein A repetitions predominant (GARP), a transmembrane protein highly expressed by activated Tregs, plays a key role in the activation of TGF-β and thus promotes the immunosuppressive action of Tregs.

Pollen and Leaf Micromorphological Characteristics of Spiny Almonds (Prunus subgenus Amygdalus) in Iran.

This study investigates the micromorphological characteristics of pollen grains and leaf epidermal cells from 20 accessions across four species of spiny almonds using scanning electron microscopy. Thirteen quantitative traits of pollen grains, including exine sculpturing, were analyzed alongside qualitative features such as shape, exine sculpture type, and aperture type. Additionally, four quantitative and five qualitative features of the leaf epidermis were examined, focusing on cuticular ornamentation patterns, types of epicuticular wax, and stomatal measurements.

Stroke and Mortality Following Carotid Endarterectomy or Carotid Artery Stenting: A 10 Year Nationwide Study in France.

Objective: This retrospective, nationwide cohort study aimed compare periprocedural stroke or death within 30 days of the procedure (PPSD30) in patients who underwent carotid endarterectomy (CEA) or carotid stenting (CAS).

Methods: This retrospective cohort study used data from the French hospital database PMSI. All patients who underwent CEA or CAS between 2010 and 2019 in France were included.

Chromosomal abnormalities in oocyte donor candidates: a French survey of over 8,200 karyotypes.

Objective: To study karyotypes of >8,200 oocyte donor candidates in nulliparous or multiparous women compared with a reference population.

Design: A retrospective observational multicentric study.

Setting: University Hospital Centers.

Long term follow-up of the STOPAGO study.

An open prospective, multicenter study enrolled 48 selected patients with chronic immune thrombocytopenia who achieved complete response for 1 year on thrombopoietin receptor agonists, half of the patients maintained a sustained response off treatment 4 years after treatment discontinuation. NCT03119974.

Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.

De novo variants adjacent to the canonical splicing sites or in the well-defined splicing-related regions are more likely to impair splicing but remain under-investigated in autism spectrum disorder (ASD). By analyzing large, recent ASD genome sequencing cohorts, we find a significant burden of de novo potential splicing-disrupting variants (PSDVs) in 5048 probands compared to 4090 unaffected siblings. We identified 55 genes with recurrent de novo PSDVs that were highly intolerant to variation.

Aligning the smiles of dating dyads causally increases attraction.

Social interaction research is lacking an experimental paradigm enabling researchers to make causal inferences in free social interactions. For instance, the expressive signals that causally modulate the emergence of romantic attraction during interactions remain unknown. To disentangle causality in the wealth of covarying factors that govern social interactions, we developed an open-source video-conference platform enabling researchers to covertly manipulate the social signals produced by participants during interactions.

Which treatment in acetabular fractures of the elderly: Osteosynthesis, osteosynthesis-THA or orthopedic treatment? 2-years retrospective outcomes of a therapeutic algorithm.

Introduction: Acetabular fractures account for 7% of osteoporotic fractures, with an epidemiological peak between 75 and 80 years of age. The aim of this study is to evaluate the results of treatment of these fractures in a population aged over 65.

Hypothesis: Surgical treatment would lead to better survival and functional outcomes in the management of acetabular fractures in subjects aged over 65.

Update on Neoadjuvant and Adjuvant BRAF Inhibitors in Papillary Craniopharyngioma: A Systematic Review.

: The recent discovery of BRAF mutation in papillary craniopharyngiomas opened new avenues for targeted therapies to control tumour growth, decreasing the need for invasive treatments and relative complications. The aim of this systematic review was to summarize the recent scientific data dealing with the use of targeted therapies in papillary craniopharyngiomas, as adjuvant and neoadjuvant treatments. : The PRISMA guidelines were followed with searches performed in Scopus, MEDLINE, and Embase, following a dedicated PICO approach.

Achievements in Applications of Antioxidants and Bioactive Compounds in Food: From Agriculture to Health Benefits.

Natural foods and food components are becoming increasingly popular worldwide because people are concerned about eating healthy diets [...