Association of systemic immune inflammation index with depression among adult type 2 diabetic patients in a tertiary hospital, Ethiopia, 2022.

Background: The inflammatory and hormonal aspects of T2DM can influence the development or worsening of depressive symptoms. While most of the burden had due consideration, the mental health impact of T2DM such as depression is often unnoticed, undiagnosed, or untreated. Despite some studies exploring depression in Ethiopian T2DM patients, none have investigated the predictive role of the Systemic Immune inflammation Index (SII) in depression.

CCND1 as a Prognostic and Diagnostic Biomarker and the Impact of Its Epigenetic Alterations on Cancer Survival.

Background: Cyclin D1 (CCND1) plays a crucial role in cell cycle regulation and has been implicated in various cancers. As is well known, cancer is caused by the accumulation of detrimental variations in the genome. In this study, we shed light on the role of CCND1 in the diagnosis and progression of cancer and aimed to provide a comprehensive analysis of CCND1 across multiple cancer types, focusing on its expression, clinical correlations, DNA methylation status, prognostic implications, genetic alterations, and immune infiltration.