Reducing confusion surrounding expert conceptions of Alzheimer's and dementia: A practical analysis.

Biological, clinicobiological and clinical conceptions of Alzheimer's disease and related dementias are being promoted simultaneously to different practical ends. The co-existence of contemporary conceptions and the 'scary label' associated with older diagnostic criteria create the possibility of misunderstanding and harm. In this comment, we argue in favour of socio-ethical interventions targeted to health workers and the general public so as to lower the uncertainties introduced by contemporary diagnostic criteria and to articulate how they relate to established criteria.

Lennard-Jones interaction parameters of Mo and W in He and N from collision cross-sections of Lindqvist and Keggin polyoxometalate anions.

Drift tube ion mobility spectrometry (DTIMS) coupled with mass spectrometry was used to determine the collision cross-sections (CCS) of polyoxometalate anions in helium and nitrogen. As the geometry of the ion, more than its mass, determines the collision cross-section with a given drift gas molecule, we found that both Lindqvist ions MoO and WO had a CCS value of 103 ± 2 Å, and both Keggin ions PMoO and PWO had a CCS value of 170 ± 2 Å. Similarly, ion mobility experiments in N led to CCS values of 223 ± 2 Å and 339 ± 4 Å for Lindqvist and Keggin anions, respectively.

Collision Cross Sections of Phosphoric Acid Cluster Anions in Helium Measured by Drift Tube Ion Mobility Mass Spectrometry.

In the last years, ion mobility mass spectrometry (IMS-MS) has improved structural analysis and compound identification by giving access to the collision cross section (CCS). An increasingly wide and accurate database of CCS values is now available but often without assessment of the influence of different instrumental settings on CCS values. Here, we present 75 CCS values in helium (CCS) for phosphoric acid cluster anions [(HPO) - H] with charge state () up to 4-.

Clinical repigmentation patterns in paediatric vitiligo.

Background: Repigmentation is an essential outcome measure in vitiligo. However, clinical studies describing vitiligo repigmentation patterns are lacking.

Objectives: To assess and clearly define the repigmentation patterns in a series of patients with vitiligo, correlating these with clinicoepidemiological characteristics.

Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

Background: A growing body of evidence supports a beneficial role for vitamin K in brain and cognition, notably in studies where animals are rendered vitamin K deficient by warfarin, a potent vitamin K antagonist (VKA). Given VKAs are commonly used oral anticoagulants in older persons, we investigated the relationship between VKA therapy and cognitive performances over 10 years in participants of the Three-City study.

Methods: The Three-City cohort included 7,133 nondemented community dwellers, aged 65 years or older at baseline.

Hypochromic vitiligo: delineation of a new entity.

Background: Hypochromic vitiligo is a rare entity that has been reported only twice under the term 'vitiligo minor', with an absence of clear delineation.

Objectives: To delineate hypochromic vitiligo through a case series of patients with typical bilateral hypopigmented lesions affecting the face and trunk.

Methods: This is a retrospective multicentric evaluation study conducted in eight departments of dermatology in France, Belgium, Senegal and Saudi Arabia.

Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes.

Non-segmental vitiligo (NSV) is an enigmatic disease with various clinical courses. To empirically identify underlying subtypes of NSV, we performed latent class analysis (LCA) of 717 consecutive patients with NSV seen between 2006 and 2012 and were analyzed. Median age was 32 yrs (14-45), median age at NSV onset was 18 yrs (8-32), and median NSV duration 5 yrs (0.