Survival analysis of the metastatic cohort of Italian Association of Medical Oncology (AIOM) GARIBALDI survey.

This analysis from the GARIBALDI study was aimed to address the role of center self-declared expertise, type and commitment on the overall survival (OS) of patients with metastatic Pancreatic Ductal Adenocarcinoma (mPDAC). Treatment-naïve patients ≥18-year with pathological diagnosis of mPDAC were enrolled. OS was defined as the time from chemotherapy start to death from any cause.

Is religion beneficial for mental health? A 9-year longitudinal study.

Background/objective: This study aimed to investigate the within-person and between-person effects of religious variables on mental health and vice versa.

Method: Using a large sample of adults residing in Germany from the GESIS Panel study ( = 8146), the random intercept cross-lagged panel model was used. Data on six dimensions of religion (i.

Trajectories of depressive symptoms and subjective well-being before and after the onset of the COVID-19 pandemic: Two six-year longitudinal studies.

Previous research investigated the trajectories of mental health and well-being during and after the onset of the COVID-19 pandemic. However, less is known about the trajectories of mental health and well-being before, during, and two years after the onset of the pandemic. The aim of the current study was to investigate the trajectory of depression symptoms and subjective well-being (i.

Artificial vitriols: a contemporary interpretation of historical ingredients.

"Vitriol" is a term that appeared during the Middle-Ages to indicate a wide range of ingredients widely used both in medicinal and alchemical recipes. Green, blue, or white vitriols are easily associated with iron(ii), copper(ii), and zinc sulphate respectively thanks to the historical sources composed in the time period when the ancient and modern nomenclatures overlapped. However, other colours of vitriols are attested throughout history, such as yellow, red, or black.

Ready-to-use graphene-related material-added multi-grade oils: characterization and performance in car engine working conditions.

The need for energy efficiency is leading to the growing use of additives to enhance the performance of oil in automotive engines. Great interest is focused on nano-additives even if to date there is still no practical use in commercial liquid lubricants. Herein, the potential of industrially scalable and low-cost graphene-related materials (GRMs) as additives to enhance the performance of oil in automotive engines is explored.

Corrigendum: Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α.

[This corrects the article DOI: 10.3389/fimmu.2024.

Critical aspects in dissolution testing of nanomaterials in the oro-gastrointestinal tract: the relevance of juice composition for hazard identification and grouping.

The dissolution of a nanomaterial (NM) in an simulant of the oro-gastrointestinal (OGI) tract is an important predictor of its biodurability . The cascade addition of simulated digestive juices (saliva, stomach and intestine), including inorganic/organic biomacromolecules and digestive enzymes (complete composition, referred to as "Type 1 formulation"), strives for realistic representation of chemical composition of the OGI tract. However, the data robustness requires consideration of analytical feasibility, such as the use of simplified media.

Optimal risk and diagnosis assessment strategies in perinatal depression: A machine learning approach from the life-ON study cohort.

This study aimed to assess the concordance of various psychometric scales in detecting Perinatal Depression (PND) risk and diagnosis. A cohort of 432 women was assessed at 10-15th and 23-25th gestational weeks, 33-40 days and 180-195 days after delivery using the Edinburgh Postnatal Depression Scale (EPDS), Visual Analogue Scale (VAS), Hamilton Depression Rating Scale (HDRS), Montgomery-Åsberg Depression Rating Scale (MADRS), and Mini International Neuropsychiatric Interview (MINI). Spearman's rank correlation coefficient was used to assess agreement across instruments, and multivariable classification models were developed to predict the values of a binary scale using the other scales.

Threat or treat: Exposure assessment and risk characterisation of chemical contaminants in soft drinks and chocolate bars in various Polish population age groups.

In the frame of the European Food Risk Assessment (EU-FORA) fellowship programme, two studies on chemical contaminants in food matrices were carried out in Warsaw, Poland, at the Department of Food Safety and Chemical Analysis, Institute of Agricultural and Food Biotechnology. The first study addressed health concerns about the dietary exposure to bisphenol A (BPA) contamination due to consumption of soft drink by Polish population. BPA is an organic additive used in the production of epoxy resins and polycarbonate plastics and because of this it is used in the internal coating of cans and in plastic bottle production.

Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis.

Background: Poor oral health has been identified as a prognostic factor potentially affecting the survival of patients with head and neck squamous cell carcinoma. However, evidence to date supporting this association has emanated from studies based on single cohorts with small-to-modest sample sizes.

Methods: Pooled analysis of 2449 head and neck squamous cell carcinoma participants from 4 studies of the International Head and Neck Cancer Epidemiology Consortium included data on periodontal disease, tooth brushing frequency, mouthwash use, numbers of natural teeth, and dental visits over the 10 years prior to diagnosis.

Happiness before and during the COVID-19 pandemic in Italy: A population-based longitudinal study.

The aims of the present study were to investigate (1) whether the COVID-19 pandemic and the restrictive measures to control its spread were associated with changes in happiness before and after the pandemic and (2) whether household size, living with a partner/spouse, living with at least one son/daughter, financial support, income loss, and job loss following the pandemic were associated with happiness after controlling for previous levels of happiness. We use data from the Italian Survey on Household Income and Wealth (SHIW). Specifically, we used longitudinal data from 2283 respondents who participated in the SHIW 2016 and SHIW 2020.

Renin-Angiotensin System Inhibitors in Patients With COVID-19: A Meta-Analysis of Randomized Controlled Trials Led by the International Society of Hypertension.

Background Published randomized controlled trials are underpowered for binary clinical end points to assess the safety and efficacy of renin-angiotensin system inhibitors (RASi) in adults with COVID-19. We therefore performed a meta-analysis to assess the safety and efficacy of RASi in adults with COVID-19. Methods and Results MEDLINE, EMBASE, ClinicalTrials.

The influence of skill-based policies on the immigrant selection process.

Understanding the type of immigration flow that maximises the expected economic benefits in the destination countries is one of the main debated topics both in the economic literature and in policy agendas worldwide. In recent years, governments have developed regulations of migration flows by adopting some form of selective immigration policy based on either human capital criteria or skill needs. Admission policies in the destination countries are likely to affect the direction and magnitude of selection as well as the socio-economic performance of immigrants.

Chlamydia suis and tetracycline resistance genes un Italian wild boar (Sus scrofa).

The aim of this study was to investigate the occurrence of Chlamydia suis and tetracycline resistance determinants in conjunctival swabs of Italian wild boars, by PCR. Extracted DNA collected from 50 wild boars from Northern and Central Italy was examined by molecular methods. One sample (2%) from the Central Italy was positive for C.

Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy.

BODIPYs are renowned fluorescent dyes with strong and tunable absorption in the visible region, high thermal and photo-stability and exceptional fluorescence quantum yields. Transition metal complexes are the most commonly used triplet photosensitisers, but, recently, the use of organic dyes has emerged as a viable and more sustainable alternative. By proper design, BODIPY dyes have been turned from highly fluorescent labels into efficient triplet photosensitizers with strong absorption in the visible region (from green to orange).

-mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis.

We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well-tolerated.

An ecological study on health inequalities in the city of Bologna (Emilia-Romagna Region, Northern Italy): bridging knowledge and action.

Background: since January 2017, a multidisciplinary research group, involving the Local Health Authority, the Municipality, and the University of Bologna, carried out a city-wide action-research project on health inequalities consisting of an ecological study over the years 2011-2015 based on indicators that are routinely available within health and social services.

Objectives: to document existing geographical inequalities in health outcomes and use of healthcare services in the city of Bologna (Emilia-Romagna Region, Northern Italy), with the aim to suggest policy action to tackle them.

Design: the results of the first phase of the above-mentioned project were reported: five related to the social determinants of health (exposure) and five related to the social determinants of ill-health (outcomes).

Environmental pollution and COVID-19: the molecular terms and predominant disease outcomes of their sweetheart agreement.

As the Coronavirus situation (COVID-19) continues to evolve, many questions concerning the factors relating to the diffusion and severity of the disease remain unanswered.Whilst opinions regarding the weight of evidence for these risk factors, and the studies published so far are often inconclusive or offer contrasting results, the role of comorbidities in the risk of serious adverse outcomes in patients affected with COVID-19 appears to be evident since the outset. Hypertension, diabetes, and obesity are under discussion as important factors affecting the severity of disease.

Intention to receive a vaccine against SARS-CoV-2 in Italy and its association with trust, worry and beliefs about the origin of the virus.

The aim of the current study was to determine the extent to which Italian people intend to receive a vaccine against SARS-CoV-2 and to investigate its associations with worry, institutional trust and beliefs about the non-natural origin of the virus. A sample of 624 people living in Italy was recruited in April 2020 using an online platform. The survey included questions about intention to receive a vaccine against SARS-CoV-2, trust, worry and beliefs about the origin of the virus.

Mental health and its psychosocial predictors during national quarantine in Italy against the coronavirus disease 2019 (COVID-19).

This research aimed at investigating the psychological impact of national quarantine in Italy, and the psychosocial factors that are may influence this impact. A convenience sample of 1569 people living in Italy responded to an online survey using virtual snowball sampling. The questionnaire included measures of mental health symptoms, well-being, worry about the epidemic of COVID-19, likelihood of infection, coping efficacy, trust in the institutional response to the epidemic of COVID-19, financial loss, perceived house size, and media exposure to COVID-19 outbreak.

Association of Hypertriglyceridemia with All-Cause Mortality and Atherosclerotic Cardiovascular Events in a Low-Risk Italian Population: The TG-REAL Retrospective Cohort Analysis.

Background Evidence regarding the relationships among high plasma triglycerides (TG), all-cause mortality, and atherosclerotic cardiovascular disease (ASCVD) events in low-to-moderate risk individuals is limited. The aim of this study was to determine whether the presence of high TG levels influences the risk of all-cause mortality and ASCVD events in a population cohort followed in the real-world clinical setting. Methods and Results A retrospective longitudinal cohort analysis using administrative databases of 3 Italian Local Health Units was performed.