LMNA::NTRK1 and PRDX1::NTRK1 Atypical Spitz Tumor: A Report of Two Additional Cases With Histological, Immunohistochemical, and Molecular Insights.

Over the past decade, advancements in molecular biology have contributed to changes in the diagnostic classification of Spitz neoplasms, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas. The recent World Health Organization classification of skin tumors identifies fusion kinases, including NTRK1, NTRK2, and NTRK3, as critical drivers of these lesions. New fusion genes have continued to expand the spectrum of known molecular alterations, particularly within the category of Spitz NTRK-rearranged lesions.

Like parents, like children… this is not always the case! A longitudinal study on the family transmission of intergroup contact.

During adolescence, opportunities for interethnic interactions can shape future attitudes toward diversity. However, it is unclear how family can influence adolescents' quality of contact in different life contexts. This study aims to fill this gap.

A Structural Equation Model for Understanding the Relationship between Cognitive Reserve, Autonomy, Depression and Quality of Life in Aging.

In recent years, aging has become a focal point of scientific research and health policies due to the growing demographic trend of an aging worldwide population. Understanding the protective and risk factors that influence aging trajectories is crucial for designing targeted interventions that support healthy aging and improve people's quality of life. The aim of this study was to explore the relationships between variables of aging.

Virtual Reality-Based Psychoeducation for Dementia Caregivers: The Link between Caregivers' Characteristics and Their Sense of Presence.

In neuropsychology and clinical psychology, the efficacy of virtual reality (VR) experiences for knowledge acquisition and the potential for modifying conduct are well documented. Consequently, the scope of VR experiences for educational purposes has expanded in the health field in recent years. In this study, we sought to assess the effectiveness of ViveDe in a psychoeducational caregiver program.

A novel analysis of interoceptive underpinnings of anxious psychopathology in COVID-19 survivors.

Introduction: SARS-CoV-2 affects brain, body, and their interchange. We investigated interoceptive mechanisms in COVID-19 survivors focusing on their potential link with psychopathology and inflammatory biomarkers.

Methods: We assessed interoceptive accuracy (IAc) and time-perceiving (TA) skills of 57 COVID-19 survivors one month after hospital discharge through, respectively, a heartbeats perception task and a time duration task.

The First- and Second-Order Ethical Reasons Approach: The Case of Human Challenge Trials.

At the height of the Covid pandemic, there was much discussion in the literature about using human challenge trials (HCTs) to expedite the development of effective Covid-19 vaccines. Historically, reluctance to fully accept HCTs has largely been due to potential conflicts with the principle of nonmaleficence in bioethics. Only a few commentators have explored this topic in depth.

Virtual Reality Combined With Psychoeducation to Improve Emotional Well-Being in Informal Caregivers of Alzheimer's Disease Patients: Rationale and Study Design of a Randomized Controlled Trial.

Objectives: Care for community-dwelling people with dementia is frequently delegated to relatives, who find themselves in the role of informal caregivers with no practical management knowledge. This situation exposes caregivers to increased risk for emotional wellbeing. The current study aims to test whether the integration of the efficacy of an immersive virtual reality (VR) experience into an online psychoeducational program impacts caregiver empathy and therefore emotional wellbeing.

"Who's Got Talent?" Change of Direction, Anthropometric Characteristics and Maturity Offset Differences Between Elite and Sub-Elite Young Soccer Player.

Agility, anthropometrics and maturity-offset have been considered fundamental for talent identification in soccer. The aim of this study is to compare 83 young soccer players (U12) from elite (28) and sub-elite (55) teams, to investigate the influences of anthropometric characteristics and maturation on Change-of-Direction (CoD) with the ball (dribbling) and without the ball. ANCOVA was run to investigate potential differences in Agility T-Test and Shuttle Dribble Test between categories while simultaneously controlling for the effects of anthropometric variables such as Peak Height Velocity (PHV), Weight, and Height.

Problematic Social Media Use Among Italian Midadolescents: Protocol and Rationale of the SMART Project.

Background: Social media (SM) use constitutes a large portion of midadolescents' daily lives as a way of peer interaction. A significant percentage of adolescents experience intense or problematic social media use (PSMU), an etiologically complex behavior potentially associated with psychological distress. To date, studies longitudinally testing for risk or protective factors of PSMU, and collecting qualitative data are still scarce among midadolescents.

Antecedents and risk factors for borderline personality disorder: Etiopathogenic models based on a multi-level meta-analysis.

Background: Empirically-based developmental psychopathology approach identified three domains involved in the emergence of borderline personality disorder (BPD): i) underlying liabilities to develop psychopathology (i.e., early patterns of internalizing and externalizing manifestations); ii) invalidating relational experiences (e.

Pairing transcutaneous vagus nerve stimulation with an intensive bimanual training in children and adolescents with cerebral palsy: study protocol of a randomized sham-controlled trial.

Background: Gross motor function impairments and manual dexterity deficits are frequently observed in children and adolescents with Cerebral Palsy (CP), having a major impact on their activity level and autonomy. Improving manual dexterity and activity level of patients with CP is often the focus of rehabilitation. Novel and adjuvant treatment methods that could support the standard training also in chronic conditions are a research priority.

Clinical decision-making process and distributive justice: The mediating role of economic analysis. Empirical evidence from Italy.

Background: The COVID-19 pandemic has not only tested the resilience of public health systems but also underscored the criticality of allocative choices on health resources. These choices, however, are not confined to health emergencies but are integral to public health decisions, which inherently grapple with limited resources. In this context, physicians play a pivotal role as the architects of clinical actions in various scenarios.

Alkali-Activated Slag as Sustainable Binder for Pervious Concrete and Structural Plaster: A Feasibility Study.

In the realm of sustainable construction materials, the quest for low-environmental-impact binders has gained momentum. Addressing the global demand for concrete, several alternatives have been proposed to mitigate the carbon footprint associated with traditional Portland cement production. Despite technological advancements, property inconsistencies and cost considerations, the wholesale replacement of Portland cement remains a challenge.

Epigenetics and Control of Tumor Angiogenesis in Melanoma: An Update with Therapeutic Implications.

Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process in the progression and metastasis of melanoma. Recent research has highlighted the significant role of epigenetic modifications in regulating angiogenesis. This review comprehensively examines the current understanding of how epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, influence angiogenic pathways in melanoma.

Assessing metarepresentational abilities in adolescence: an exploratory study on relationships between definitional competence and theory of mind.

Introduction: Several developmental changes occur in adolescence, particularly in the metarepresentational domain, which allows and promotes adaptive sociality. We explored the possible relationships between theory of mind (ToM) and definitional competence, both metarepresentational, beyond age and gender effects.

Methods: To reach our goals, we involved 75 adolescents (age range 14-19 years, = 15.

The impact of the European Union emissions trading system on carbon dioxide emissions: a matrix completion analysis.

Despite the negative externalities on the environment and human health, today's economies still produce excessive carbon dioxide emissions. As a result, governments are trying to shift production and consumption to more sustainable models that reduce the environmental impact of carbon dioxide emissions. The European Union, in particular, has implemented an innovative policy to reduce carbon dioxide emissions by creating a market for emission rights, the emissions trading system.

Walking symmetry is speed and index dependent.

Gait symmetry is one of the most informative aspects describing the quality of gait. Many indices have been proposed to quantify gait symmetry. Among them, indices focusing on the comparison of the two body sides (e.

No Impact of Anthropometric and Fitness Factors on Speed-Agility in Young Soccer Players: Is It a Cognitive Influence?

Purpose: Agility in young soccer players has long been associated with physical attributes like strength, speed, and power. The aims of this study were to investigate the relationship between cognitive factors and agility performance in this unique population.

Methods: 39 young soccer players age 13.

Effects of high-frequency mechanical stimuli on flow related vascular cell biology.

Mechanical forces related to blood pressure and flow patterns play a crucial role in vascular homeostasis. Perturbations in vascular stresses and strain resulting from changes in hemodynamic may occur in pathological conditions, leading to vascular dysfunction as well as in vascular prosthesis, arteriovenous shunt for hemodialysis and in mechanical circulation support. Turbulent-like blood flows can induce high-frequency vibrations of the vessel wall, and this stimulus has recently gained attention as potential contributors to vascular pathologies, such as development of intimal hyperplasia in arteriovenous fistula for hemodialysis.

Recent Advancements in Acrylic Fabric Applications: A Comprehensive Review and Future Trends.

Acrylic fibres, as synthetic polymers, have been used extensively in the textile industry to create a wide variety of products, ranging from apparel and home furnishings to car rooftops and carbon fibres. Their widespread application is attributed to a combination of desirable properties, including a soft, wool-like texture, chemical stability, and robust mechanical characteristics. Furthermore, the chemical structure of acrylic fibres can be modified to imbue them with additional features, such as antimicrobial properties, fire resistance, conductivity, water repellency, and ultraviolet protection.

Psychological dissociation and temporal integration/segregation across the senses: An experimental study.

There are no studies that have experimentally tested how temporal integration/segregation of sensory inputs might be linked to the emergence of dissociative experiences and alterations of emotional functioning. Thirty-six participants completed 3 sensory integration tasks. Psychometric thresholds were estimated as indexes of temporal integration/segregation processes.

MRI evidence of gray matter loss in COVID-19 patients with cognitive and olfactory disorders.

Objective: The aim of this study was to assess COVID-19-related gray matter (GM) structural alterations in two distinct groups of patients presenting with the prevailing and distinctive COVID-19-related neurological symptoms - isolated olfactory disorders as sole neurological manifestation (COVID-OD) and cognitive disorders (COVID-CD) - as compared to a control group of unaffected individuals.

Methods: The study included 61 COVID-CD patients (57 [60-63] years, 62% females), 84 COVID-OD patients (49 [35-57] years, 60% females), and 17 controls (51 [41-52] years, 41% females). Region-based morphometry (RBM) and voxel-based morphometry (VBM) were performed on T1-weighted MRI scans to assess GM regional volume and voxel-wise density differences between COVID-19 patients and controls.

Dry Needling and Acupuncture for Scars-A Systematic Review.

: This research aims to synthesize existing data on the evidence gap in scar treatment and evaluate the effectiveness of acupuncture and dry needling in treating scars and related symptoms. : The article adhered to the PRISMA 2020 statement for recommended reporting elements in systematic reviews. The inclusion criteria followed the PICO methodology.