Is There a Relationship Between Prenatal Dexamethasone and Postnatal Fructose Overexposure and Testicular Development, Function, and Oxidative Stress Parameters in Rats?

Prenatal glucocorticoid overexposure alters the developmental program of fetal reproductive organs and results in numerous changes that can lead to various disorders later in life. Moderate fructose consumption during childhood and adolescence may impair the development and function of reproductive organs. The aim of this study was to investigate the effects of prenatal dexamethasone (Dx) exposure in combination with postnatal fructose overconsumption on testicular development and function in fetal and adult male rat offspring.

Redescription of the poorly known Allopodoiulus schioedtei (Verhoeff, 1898) and the identity of Xestoiulus luteus (Attems, 1951) (Diplopoda: Julida: Julidae).

Based on old type material and freshly collected specimens, we evaluate and clarify the taxonomic status of two poorly known Balkan species, Allopodoiulus schioedtei (Verhoeff, 1898) and Xestoiulus luteus (Attems, 1951), and propose their synonymy with X. luteus syn. nov.

Complex interplay between the microfluidic and optical properties of Hoplia sp. beetles.

Background: All living organisms exist in a world affected by many external influences, especially water and light. Photonic nanostructures present in certain insects, have evolved over time in response to diverse environmental conditions, facilitating communication within and between species, camouflage, thermoregulation, hydration, and more. Up to now, only a few insect species have been discovered whose elytron changes its color due to permeation of water (or its vapor) through cuticle.

Uncovering the Role of Autochthonous Deteriogenic Biofilm Community: Rožanec Mithraeum Monument (Slovenia).

The primary purpose of the study, as part of the planned conservation work, was to uncover all aspects of autochthonous biofilm pertaining to the formation of numerous deterioration symptoms occurring on the limestone Rožanec Mithraeum monument in Slovenia. Using state-of-the-art sequencing technologies combining mycobiome data with observations made via numerous light and spectroscopic (FTIR and Raman) microscopy analyses pointed out to epilithic lichen Gyalecta jenensis and its photobiont, carotenoid-rich Trentepohlia aurea, as the origin of salmon-hued pigmented alterations of limestone surface. Furthermore, the development of the main deterioration symptom on the monument, i.

Exploring the Antibacterial Potential of Lamiaceae Plant Extracts: Inhibition of Bacterial Growth, Adhesion, Invasion, and Biofilm Formation and Degradation in PAO1.

In response to the global rise in antibiotic resistance and the prevalence of bacterial biofilm-related infections, the antibacterial efficacy of methanolic, ethanolic, and aqueous extracts of 18 Lamiaceae plants from Serbia was evaluated. The total coumarins and triterpenes were detected spectrophotometrically, while a microdilution assay measured their effects on bacterial growth. Additionally, the impact of these extracts was assessed on PAO1 adhesion and invasion in human fibroblasts and biofilm formation and degradation.

Main features and disease outcome of congenital myotonic dystrophy - experience from a single tertiary center.

Congenital myotonic dystrophy type 1 (CDM1) is a rare neuromuscular disease. The aim of our study was to evaluate clinical variability of CDM1 and factors that may influence survival in CDM1. Research included 24 pediatric patients with CDM1.

A review of the genus Fitzinger, 1833 (Gastropoda, Eupulmonata, Pristilomatidae) in Serbia: diversity, distribution and the description of a new species.

In this paper, the genus Fitzinger, 1833 in Serbia is reviewed. All previous literature data on this genus from Serbia are summarised and used to discuss its distribution in the country and create distribution maps, supplemented by new material collected by the authors. All Serbian species are figured.

Chemical defence of a centipede (Clinopodes flavidus).

Chemical substances are of utmost importance for the biotic interactions between animals and their predators/parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda).

Integrative investigation of hematotoxic effects induced by low doses of lead, cadmium, mercury and arsenic mixture: In vivo and in silico approach.

The effect of the lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) mixture (MIX) on hematotoxicity development was investigated trough combined approach. In vivo subacute study (28 days) was performed on rats (5 per group): a control group and five groups orally exposed to increasing metal(loid) mixture doses, MIX 1- MIX 5 (mg/kg bw./day) (Pb: 0.

Potential application of green extracts rich in phenolics for innovative functional foods: natural deep eutectic solvents as media for isolation of biocompounds from berries.

The health-promoting effects of berries have attracted attention due to the possible application of their extracts as functional ingredients in food products. Natural deep eutectic solvents (NADESs) are a new generation of environmentally friendly solvents for the extraction of natural products, and they are green alternatives to organic solvents, and they can improve the solubility, stability, and bioavailability of isolated biocompounds. In this study, an efficient eco-friendly method was used for the extraction of phenolic compounds from different berries: chokeberries, blueberries, and black goji berries with a range of eutectic solvents consisting of hydrogen bond acceptors (HBAs) such as choline chloride, L-proline, L-glycine, and L-lysine and hydrogen bond donors (HBDs) such as malic, citric, tartaric, lactic and succinic acids, glucose and glycerol.

Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach.

Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach.

Novel hybrid compounds of sclareol and doxorubicin as potential anticancer nanotherapy for glioblastoma.

Two novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid compounds have a 1:1 molar ratio of covalently linked SC and DOX. They have demonstrated promising anticancer properties, especially in glioblastoma cells, and have also shown potential in treating multidrug-resistant (MDR) cancer cells that express the P-glycoprotein (P-gp) membrane transporter.

A new subspecies of the subterranean beetle Speoplanes biocovensis Mller, 1934 (Coleoptera: Leiodidae: Cholevinae: Leptodirini) from Bosnia and Herzegovina: the first occurrence of the genus outside Croatia.

A new subterranean leptodirine leiodid beetle, Speoplanes biocovensis bosnicus Vrbica, Vesovi, Raa & uri, ssp. n., is described and diagnosed from a pit in southern Bosnia and Herzegovina.

Single-molecule RNA sizing enables quantitative analysis of alternative transcription termination.

Transcription, a critical process in molecular biology, has found many applications in RNA synthesis, including mRNA vaccines and RNA therapeutics. However, current RNA characterization technologies suffer from amplification and enzymatic biases that lead to loss of native information. Here, we introduce a strategy to quantitatively study both transcription and RNA polymerase behaviour by sizing RNA with RNA nanotechnology and nanopores.

Morphology of the pygidial glands and chemical composition of their secretions in two species of tiger beetles (Carabidae: Cicindelinae).

Pygidial glands are a common feature of all adephagans and their products play an important role in defense against predators. The morphology of the pygidial glands and the chemistry of their secretion were studied for the first time in two species of tiger beetles - Cicindela (Cicindela) sylvicola Dejean, 1822 and Cylindera (Cylindera) germanica (Linnaeus, 1758). The glands were examined by both bright-field microscopy and nonlinear microscopy.

Phytochemistry and Micromorphology of Epicuticular Waxes in Four Juniper Species With Fragmented Distribution in the Balkans.

The cuticle is important in the interaction between the plant and its environment, especially in the dry areas. Four species of junipers from the section Sabina wild growing in the Balkans were selected to study leaf wax composition using GC/MS and GC-FID and its surface morphology under SEM to understand the correlation between the distribution and/or habitat of these species and their cuticles. SEM micrographs showed continuous, smooth epicuticular layers with crusts in all species but with a species-specific distribution of different 3D crystalloid types and different cuticle thickness.

The common nase (Chondrostoma nasus) as an indicator of aquatic pollution and human health risk assessment associated with its consumption.

Individuals of common nase were sampled from three waterbodies (Kačer river, Zaovine, and Medjuvršje reservoirs) with different characteristics, types, and levels of anthropogenic pressure. The aims of this study were to determine the concentrations of 26 elements in gills, liver, and muscle using inductively coupled plasma optical emission spectrometry (ICP-OES); determine the concentrations of 17 organochlorine pesticides (OCPs) in muscle tissue using gas chromatography with mass spectrometric detection (GC-MS); compare these findings with fish condition (CF); and conduct human health risk and benefit assessments due to consumption of fish meat using target hazard quotient, target carcinogenic risk factor, Se:Hg molar ratio, Na:K and Ca:Mg ratios, and contribution of elements to human diet. Results indicated that in addition to the fact that the type of ecosystem (lentic vs.

The genus Strasser, 1962, stat. nov. and sp. nov., a new bizarre, highly modified troglobiotic millipede (Diplopoda, Julida, Julidae) from Albania, Balkan Peninsula.

Strasser, 1962, is raised to the genus level and a new hydrophilous species, , is described from the second deepest pit in Albania. This species is characterized by a highly modified head and body for a presumably semiaquatic or hygropetric life and filtering diet. It is by far the most bizarrely modified cave-dwelling julid known.

Drivers of species knowledge across the tree of life.

Knowledge of biodiversity is unevenly distributed across the Tree of Life. In the long run, such disparity in awareness unbalances our understanding of life on Earth, influencing policy decisions and the allocation of research and conservation funding. We investigated how humans accumulate knowledge of biodiversity by searching for consistent relationships between scientific (number of publications) and societal (number of views in Wikipedia) interest, and species-level morphological, ecological, and sociocultural factors.

Karadenizia, a new monospecific pachyiuline genus (Diplopoda: Julida: Julidae) from Turkey.

The present paper is dedicated to the description of the monospecific pachyiuline genus Karadenizia gen. nov. with the type species K.

Rat brown adipose tissue thermogenic markers are modulated by estrous cycle phases and short-term fasting.

Brown adipose tissue (BAT) converts chemical energy into heat to maintain body temperature. Although fatty acids (FAs) represent a primary substrate for uncoupling protein 1 (UCP1)-dependent thermogenesis, BAT also utilizes glucose for the same purpose. Considering that estrous cycle effects on BAT are not greatly explored, we examined those of 6-h fasting on interscapular BAT (iBAT) thermogenic markers in proestrus and diestrus.

Maurieseuma, a new genus to accommodate Hylebainosoma nontronense Mauriès & Kime, 1999, and the revalidation of the genus Romanosoma Mauriès, 2015 (Diplopoda: Chordeumatida: Haaseidae).

A new genus, Maurieseuma gen. nov., is established to accommodate the species Hylebainosoma nontronense Mauriès & Kime, 1999.