12,830 results match your criteria: "University of Bath[Affiliation]"

Background: A large body of evidence links stressful life events with depression. However, little is understood about the role of perceived impact in this association.

Methods: We performed regression analysis to investigate whether self-reported stress reactivity (derived by regressing the impact-weighted life event score on the unweighted score) moderated the association between stressful life events and depressive symptoms in adolescents from the Avon Longitudinal Study of Parents and Children cohort (n = 4791), controlling for age at outcome, sex, ethnicity, and maternal education.

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Objectives: To develop a tool to 'risk score' the potential harm of a medication error by estimating the probability of a range of potential consequences, and assess its feasibility, validity, and reliability.

Methods: The risk score tool described five levels of potential harm developed from an existing risk matrix. Judges estimated the likelihood of harm matching each level, from which a risk score (0-10) was calculated.

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Introduction: Tobacco consumption is a leading cause of mortality globally. Eighty percent of these deaths occur in low- and middle-income countries (LMICs). Despite this, there is a large treatment gap due to both demand and supply-side barriers.

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Background: The search for alternatives to antibiotic growth promoters in poultry production has increased interest in probiotics. However, the complexity of the interactions between probiotics, gut microbiome, and the host hinders the development of effective probiotic interventions. This study explores metabolic modelling to examine the possibility of designing informed probiotic interventions within poultry production.

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Background: Epigenetic age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Departures, known as epigenetic age acceleration (EAA), are common and have been linked to various traits and future disease risk.

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Objectives: To summarise and evaluate Cochrane reviews of pharmacological therapies for adults with fibromyalgia syndrome (FMS) pain.

Methods: Systematic search of Cochrane Database of Systematic Reviews to May 2024. Generic quality assessment used AMSTAR-2 criteria, validity checks of potentially critical factors in evaluation of analgesic efficacy, and assessment of susceptibility of results to publication bias.

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Background: Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression ('treatment-naïve' CLL). The objective of this pilot study was to assess the feasibility and preliminary safety of an exercise program in treatment-naïve CLL. We also sought to preliminarily assess the impact of the exercise program on disease activity, as it has been proposed that exercise training may reduce disease outgrowth in treatment-naïve CLL.

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Community pharmacist involvement in social prescribing for mental health: a qualitative study.

Prim Health Care Res Dev

December 2024

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath and Northeast Somerset, UK.

Aim: We aimed to explore participant perspectives on social prescribing (SP) for mental health and well-being and the acceptability of community pharmacists (CP) as members of SP pathways that support people with mild to moderate depression and anxiety.

Background: SP aims to support people with poor health related to socio-demographic determinants. Positive effects of SP on self-belief, mood, well-being, and health are well documented, including a return to work for long-term unemployed.

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BRITSpA at 10.

Rheumatology (Oxford)

December 2024

Norfolk and Norwich University Hospital NHS Foundation Trust and Norwich Medical School, University of East Anglia, Norwich, UK.

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Global food system governance increasingly relies on multistakeholder initiatives (MSIs) that aim to include those who are affected by and/or affected by an issue. Multistakeholderism's perceived legitimacy is premised on both its outcomes (output legitimacy) and processes (input legitimacy), the latter in turn based on four key rationales: inclusiveness, procedural fairness, consensual orientation and transparency. To date, evidence on the ineffectiveness of MSI's outcomes undermines its claims to output legitimacy.

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Introduction: Co-production involves researchers, practitioners and people with lived experience working in a collaborative manner, with shared power. The potential benefits of co-production are well documented. However, there is little research describing the experience of having been involved in co-production from the perspective of Experts By Lived Experience (EBLE).

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Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure.

Eur J Psychotraumatol

December 2024

Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.

PTSD is comorbid with a number of other mental health difficulties and the link between voice hearing and PTSD has been explored in adult samples. To compare the trauma history, symptomatology, and cognitive phenotypes of children and adolescents with a PTSD diagnosis following exposure to multiple traumatic events presenting with voice hearing with those who do not report hearing voices. Participants ( = 120) were aged 8-17 years and had PTSD following exposure to multiple traumas.

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Directly transmitted infectious diseases spread through social contacts that change over time, but outbreak models typically make simplifying assumptions about network structure and dynamics. To assess how common assumptions relate to real-world interactions, we analysed 11 networks from five settings and developed metrics, capturing crucial epidemiological features of these networks. We developed a novel metric, the 'retention index', to characterize the distribution of retained contacts over consecutive time steps relative to fully static and dynamic networks.

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Osteochondral lesions of talus.

Bone Joint Res

December 2024

Department of Mechanical Engineering, University of Bath, Bath, UK.

Cite this article:  2024;13(12):790–792.

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A machine learning approach for identifying anatomical biomarkers of early mild cognitive impairment.

PeerJ

December 2024

Department of Fundamental and Applied Sciences, Faculty of Science and Information Technology, Universiti Teknologi PETRONAS, Seri Iskandar, Perak, Malaysia.

Background: Alzheimer's Disease (AD) poses a major challenge as a neurodegenerative disorder, and early detection is critical for effective intervention. Magnetic resonance imaging (MRI) is a critical tool in AD research due to its availability and cost-effectiveness in clinical settings.

Objective: This study aims to conduct a comprehensive analysis of machine learning (ML) methods for MRI-based biomarker selection and classification to investigate early cognitive decline in AD.

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Talpid3 is a basal body protein required for the formation of primary cilia, an organelle involved in signal transduction. Here, we asked if Talpid3 has a role in the regulation of differentiation and/or self-renewal of ES cells and whether cells lacking cilia due to a deletion in Talpid3 can be reprogrammed to induced pluripotent stem (iPS) cells. We show that mouse embryonic limb fibroblasts which lack primary cilia with a targeted deletion in the () gene can be efficiently reprogrammed to iPS cells.

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Frequently engaging in a positive health behaviour, like following a vegetarian or vegan (veg*n) diet, can bring benefits to both the individual and society. We investigated the roles of two psychological determinants of behaviour-instigation habits and self-regulation strategy use-in a cohort of individuals who were newly transitioning to a veg*n diet. In a longitudinal study over 6 months (7 waves including baseline), 222 individuals transitioning to a veg*n diet reported their monthly habit strength, craving frequency, self-regulation strategies and animal product consumption.

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An unexamined assumption in many studies of learning and decision making is that people learn underlying probability distributions. However, the acquisition of distributional knowledge is rarely the focus of investigations. We report five experiments ( = 580 adults) that provide this focus and highlight the factors that impact people's ability to accurately learn and reproduce underlying distributions.

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Meta-analyses uncover the genetic architecture of Idiopathic Inflammatory Myopathies.

Arthritis Rheumatol

December 2024

Institute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

Objective: Idiopathic inflammatory myopathies (myositis, IIMs) are rare, systemic autoimmune disorders that lead to muscle inflammation, weakness, and extra-muscular manifestations, with a strong genetic component influencing disease development and progression. Previous genome-wide association studies identified loci associated with IIMs. In this study, we imputed data from two prior genome-wide myositis studies and analyzed the largest myositis dataset to date to identify novel risk loci and susceptibility genes associated with IIMs and its clinical subtypes.

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Anisogamy and sex roles: a commentary.

Evol Lett

December 2024

Department of Life Sciences, Milner Centre for Evolution, University of Bath, Bath BA2 7AY, United Kingdom.

The origin and maintenance of sex differences in reproductive behavior (often labeled sex roles) have remained controversial topics, and recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles. We are glad to see that our study (Mokos et al., 2021) generated a healthy debate, and in agreement with recent commentaries (Janicke, 2024; Lehtonen & Parker, 2024) we call for a more comprehensive approach to understanding sex role evolution.

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The integration of artificial intelligence (AI) into healthcare communication has rapidly evolved, driven by advancements in large language models (LLMs) such as Chat Generative Pre-trained Transformer (ChatGPT). This literature review explores AI's role in patient-physician interactions, particularly focusing on its capacity to enhance communication by bridging language barriers, summarizing complex medical data, and offering empathetic responses. AI's strengths lie in its ability to deliver comprehensible, concise, and medically accurate information.

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JUNB O-GlcNAcylation-Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary Fibrosis.

Adv Sci (Weinh)

December 2024

Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany.

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with substantial unmet medical needs. While aberrant epithelial remodeling is a key factor in IPF progression, the molecular mechanisms behind this process remain elusive. Harnessing a 3D patient-derived organoid model and multi-omics approach, the first inventory of the connection between metabolic alteration, chromatin accessibility, and transcriptional regulation in IPF aberrant epithelial remodeling is provided.

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Autistic adolescents are at greater risk of chronic pain, but it is unclear how autistic features may relate to individual aspects of chronic pain. As autism traits exist in the general population as well, it is important to know if autistic traits could impact how effective chronic pain management is for adolescents. Here we examined autistic traits in 112 patients (12-18yrs) recruited from a UK national specialist adolescent pain rehabilitation programme.

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