Drug Release Nanoparticle System Design: Data Set Compilation and Machine Learning Modeling.

Magnetic nanoparticles (NPs) are gaining significant interest in the field of biomedical functional nanomaterials because of their distinctive chemical and physical characteristics, particularly in drug delivery and magnetic hyperthermia applications. In this paper, we experimentally synthesized and characterized new FeO-based NPs, functionalizing its surface with a 5-TAMRA cadaverine modified copolymer consisting of PMAO and PEG. Despite these advancements, many combinations of NP cores and coatings remain unexplored.

Artificial Intelligence-Driven Modeling for Hydrogel Three-Dimensional Printing: Computational and Experimental Cases of Study.

Determining the values of various properties for new bio-inks for 3D printing is a very important task in the design of new materials. For this purpose, a large number of experimental works have been consulted, and a database with more than 1200 bioprinting tests has been created. These tests cover different combinations of conditions in terms of print pressure, temperature, and needle values, for example.

Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective.

Background: Vitamin D deficiency is linked to worse outcomes in patients with chronic liver diseases (CLD). However, data in patients with autoimmune hepatitis (AIH) remain limited.

Aims: We aimed to assess the impact of vitamin D deficiency on the outcomes of individuals with AIH.

Differences in Physical Demands and Player's Individual Performance Between Winning and Losing Quarters on U-18 Basketball Players During Competition.

This study examines how physical demands and individual performance influence quarter results in under-18 basketball players during a six-day basketball tournament. : Twelve male players from an elite Spanish team were tracked using inertial microsensors to monitor external load variables (player load, steps, and dynamic stress load). Individual performance was assessed using the performance index rating (PIR).

Automatic discrimination between neuroendocrine carcinomas and grade 3 neuroendocrine tumors by deep learning of H&E images.

Neuroendocrine neoplasms (NENs) arise from diffuse neuroendocrine cells and are categorized as either well-differentiated and less proliferative Neuroendocrine Tumors (NETs), divided into low (G1), middle (G2), and high grades (G3), or poorly differentiated, and more proliferative Neuroendocrine Carcinomas (NECs). Low-grade NENs typically necessitate surgical intervention, whereas high-grade ones often require chemotherapy. However, low-grade NENs may exhibit aggressive behavior.

Birthplace Effect in Soccer: A Systematic Review.

Birthplace is a contextual variable that influences the talent development process of soccer players. The main objective of this systematic review was to compile the scientific literature on the effect of birthplace in soccer. This is the first systematic review to investigate how this contextual factor relates to talent development in soccer.

TET3 regulates terminal cell differentiation at the metabolic level.

TET-family members play a critical role in cell fate commitment. Indeed, TET3 is essential to postnatal development due to yet unknown reasons. To define TET3 function in cell differentiation, we have profiled the intestinal epithelium at single-cell level from wild-type and Tet3 knockout mice.

Estimating the Reduction of Socioeconomic Inequalities for a More Physically Active Society: A Cross-Sectional Study of the European Union Country Members.

Background: Socioeconomic inequalities significantly impact the accessibility of resources necessary for physical activity, thereby influencing overall physical activity levels and contributing to broader health disparities. Nevertheless, evidence is lacking on quantifying the increase of people who would be physically active through reducing inequalities by a higher socioeconomic position.

Methods: We conducted secondary data analysis on the 2017 cross-sectional survey of the European Union's population aged ≥18 years (n = 27,538).

Drug-delivery and biological activity in colorectal cancer of a supramolecular porous material assembled from heptameric chromium-copper-adenine entities.

The therapeutic application of drugs often faces challenges due to non-specific distribution, inadequate dosification and degradation, which limits their efficacy. Two primary strategies are employed to overcome these issues: the use of derivatives of the active substances and incorporation of those into porous materials. The latter, involving materials such as zeolites, metal-organic frameworks (MOFs), and hydrogels, has shown promising results in protecting the active ingredients from degradation and enabling a controlled release.

Machine learning analysis of a large set of homopolymers to predict glass transition temperatures.

Glass transition temperature of polymers, Tg, is an important thermophysical property, which sometimes can be difficult to measure experimentally. In this regard, data-driven machine learning approaches are important alternatives to assess Tg values, in a high-throughput way. In this study, a large dataset of more than 900 polymers with reported glass transition temperature (T) was assembled from various public sources in order to develop a predictive model depicting the structure-property relationships.

The mechanics of the retina: Müller glia role on retinal extracellular matrix and modelling.

The retina is a highly heterogeneous tissue, both cell-wise but also regarding its extracellular matrix (ECM). The stiffness of the ECM is pivotal in retinal development and maturation and has also been associated with the onset and/or progression of numerous retinal pathologies, such as glaucoma, proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), epiretinal membrane (ERM) formation or uveitis. Nonetheless, much remains unknown about the biomechanical milieu of the retina, and specifically the role that Müller glia play as principal mechanosensors and major producers of ECM constituents.

The transmission of social inequalities through economic difficulties and lifestyle factors on body mass index: An intersectional mediation analysis in the Swedish population.

Body mass index (BMI) has increased in Sweden, disproportionally for socially disadvantaged groups, including women, low-educated, and immigrants, who may also face economic constraints, physical inactivity, and poor-quality diets. Intersectional public health research aims to unravel such complex social inequalities, but the intersectional transmission of inequalities to BMI remains unexplored. We aimed to examine intersectional inequalities in BMI mediated by economic strain and health-related lifestyle in the Swedish population.

Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer.

Background: Increased cancer stem cell (CSC) content and SOX2 overexpression are common features in the development of resistance to therapy in hormone-dependent breast cancer, which remains an important clinical challenge. SOX2 has potential as biomarker of resistance to treatment and as therapeutic target, but targeting transcription factors is also challenging. Here, we examine the potential inhibitory effect of different polyoxometalate (POM) derivatives on SOX2 transcription factor in tamoxifen-resistant breast cancer cells.

Glucuronide metabolites of trans-ε-viniferin decrease triglycerides accumulation in an in vitro model of hepatic steatosis.

Trans-ε-viniferin, a resveratrol dimer found mainly in grapevine wood, has shown protective capacities against hepatic steatosis in vivo. Nevertheless, this compound is very poorly bioavailable. Thus, the aim of the present study is to determine the potential anti-steatotic properties of 1 and 10 µM of trans-ε-viniferin and its four glucuronide metabolites in AML-12 cells treated with palmitic acid as an in vitro model of hepatic steatosis.

Magnetic imaging of individual magnetosome chains in magnetotactic bacteria.

While significant advances have been made in exploring and uncovering the promising potential of biomagnetic materials, persistent challenges remain on various fronts, notably in the characterization of individual elements. This study makes use of advanced modes of Magnetic Force Microscopy (MFM) and tailored MFM probes to characterize individual magnetotactic bacteria in different environments. The characterization of these elements posed a significant challenge, as the magnetosomes, besides presenting low magnetic signal, are embedded in bacteria of much larger size.

NANO.PTML model for read-across prediction of nanosystems in neurosciences. computational model and experimental case of study.

Neurodegenerative diseases involve progressive neuronal death. Traditional treatments often struggle due to solubility, bioavailability, and crossing the Blood-Brain Barrier (BBB). Nanoparticles (NPs) in biomedical field are garnering growing attention as neurodegenerative disease drugs (NDDs) carrier to the central nervous system.

Physical Performance Changes in Season are Associated with GPS Data in Soccer Players.

This study investigated the associations between pre-season and in-season performance with external workload in professional soccer players. Twenty-one players completed hamstring strength, countermovement jump (CMJ), 20-m sprint, and Yo-Yo intermittent recovery tests before (pre-season) and after 8 weeks (in-season). External workload (total distance, high-intensity running distance, number of sprints, and power plays) was quantified during this period, and used to divide the average above and below subgroups outcome by outcome for further analyses.

Do Elite Basketball Players Maintain Peak External Demands throughout the Entire Game?

Consideration of workload intensity and peak demands across different periods of basketball games contributes to understanding the external physical requirements of elite basketball players. Therefore, the aim of this study was to investigate the average intensity and peak demands encountered by players throughout game quarters. PlayerLoad per minute and PlayerLoad at three different time samples (30 s, 1 min, and 3 min) were used as workload metrics.

Epigenetics Provides New Perspectives for Diagnosis and Evidence-Based Guidance of Chemotherapy in Cancer.

Strong epigenetic pan-cancer biomarkers are required to meet several current, urgent clinical needs and to further improve the present chemotherapeutic standard. We have concentrated on the investigation of epigenetic alteration of the gene, which is frequently epigenetically dysregulated in a number of cancers in specific developmental stages. Distinct DNA methylation profiles were identified in our data on early urothelial cancer.